DAAF5_HUMAN - dbPTM
DAAF5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DAAF5_HUMAN
UniProt AC Q86Y56
Protein Name Dynein assembly factor 5, axonemal {ECO:0000303|PubMed:25232951, ECO:0000312|HGNC:HGNC:26013}
Gene Name DNAAF5 {ECO:0000303|PubMed:25232951, ECO:0000312|HGNC:HGNC:26013}
Organism Homo sapiens (Human).
Sequence Length 855
Subcellular Localization Cytoplasm . Cytoplasmic granule . Observed only in the cytoplasm of ciliated cells and absent from cilia.
Protein Description Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility..
Protein Sequence MAALGVAEAVAAPHPAEGAETAEAVELSRALSRLLPGLEADSKPGRRRALEALRRALEEPGPAADPTAFQGPWARLLLPRLLRCLSDPAEGCRALAVHLLDLGLRRAARPRDALPRLLPALAARLAGPVPARRPPEACEELRLALVQLLGLAVDLCGAALAPHLDDALRALRCSLLDPFAAVRRESCSCAAALAQATPDHFHMQSESLIGPLMQTISHQHWKVRVAAIEATGAVIHFGNGKSVDDVLSHFAQRLFDDVPQVRRAVASVVGGWLLCLRDRYSFFHKLIPLLLSSLNDEVPEVRQLAASLWEDVGLQWQKENEEDLKDKLDFAPPTPPHYPPHERRPVLGCRELVFRNLSKILPALCHDITDWVVGTRVKSAQLLPVLLLHAEDHATQHLEVVLRTLFQACTDEEAAVVQSCTRSAELVGTFVSPEVFLKLILSTLKKTPSASGLLVLASAMRGCPREALQPHLAAIATELAQAHICQASENDLYLERLLLCVQALVSVCHEDCGVASLQLLDVLLTIVALAGATGLRDKAQETMDSLAMVEGVSSCQDLYRKHIGPLLERVTASHLDWTAHSPELLQFSVIVAQSGPALGEALPHVVPTLRACLQPSQDPQMRLKLFSILSTVLLRATDTINSQGQFPSYLETVTKDILAPNLQWHAGRTAAAIRTAAVSCLWALTSSEVLSAEQIRDVQETLMPQVLTTLEEDSKMTRLISCRIINTFLKTSGGMTDPEKLIRIYPELLKRLDDVSNDVRMAAASTLVTWLQCVKGANAKSYYQSSVQYLYRELLVHLDDPERAIQDAILEVLKEGSGLFPDLLVRETEAVIHKHRSATYCEQLLQHVQAVPATQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAALGVAEA
------CCHHCHHHH		22223895
21PhosphorylationHPAEGAETAEAVELS
CCCCCHHHHHHHHHH		28787133
32PhosphorylationVELSRALSRLLPGLE
HHHHHHHHHHCCCCC		24247654
42PhosphorylationLPGLEADSKPGRRRA
CCCCCCCCCHHHHHH		20860994
43AcetylationPGLEADSKPGRRRAL
CCCCCCCCHHHHHHH		26051181
43 (in isoform 2)Ubiquitination-21890473
43 (in isoform 1)Ubiquitination-21890473
43UbiquitinationPGLEADSKPGRRRAL
CCCCCCCCHHHHHHH		21890473
43SumoylationPGLEADSKPGRRRAL
CCCCCCCCHHHHHHH		-
80 (in isoform 3)Ubiquitination-21906983
140 (in isoform 3)Ubiquitination-21906983
155 (in isoform 3)Ubiquitination-21906983
165 (in isoform 3)Ubiquitination-21906983
175 (in isoform 3)Ubiquitination-21906983
241UbiquitinationVIHFGNGKSVDDVLS
EEECCCCCCHHHHHH		-
318 (in isoform 2)Ubiquitination-21890473
318 (in isoform 1)Ubiquitination-21890473
318UbiquitinationDVGLQWQKENEEDLK
HHCHHHHHCCHHHHH		21906983
334PhosphorylationKLDFAPPTPPHYPPH
HCCCCCCCCCCCCCC		22617229
338PhosphorylationAPPTPPHYPPHERRP
CCCCCCCCCCCCCCC		28450419
359UbiquitinationLVFRNLSKILPALCH
HHHHHHHHHHHHHHC		-
378UbiquitinationWVVGTRVKSAQLLPV
HHHCCCCCCCHHHHH		-
443PhosphorylationFLKLILSTLKKTPSA
HHHHHHHHHCCCCCH		20068231
445AcetylationKLILSTLKKTPSASG
HHHHHHHCCCCCHHH		25953088
445 (in isoform 2)Ubiquitination-21890473
445 (in isoform 1)Ubiquitination-21890473
445UbiquitinationKLILSTLKKTPSASG
HHHHHHHCCCCCHHH		21906983
446UbiquitinationLILSTLKKTPSASGL
HHHHHHCCCCCHHHH		-
447PhosphorylationILSTLKKTPSASGLL
HHHHHCCCCCHHHHH		20071362
451PhosphorylationLKKTPSASGLLVLAS
HCCCCCHHHHHHHHH		-
561 (in isoform 2)Ubiquitination-21890473
561 (in isoform 1)Ubiquitination-21890473
561UbiquitinationSCQDLYRKHIGPLLE
HHHHHHHHCHHHHHH		21906983
655 (in isoform 2)Ubiquitination-21890473
655 (in isoform 1)Ubiquitination-21890473
655UbiquitinationSYLETVTKDILAPNL
HHHHHHCCHHHCCCC		21906983
701PhosphorylationQIRDVQETLMPQVLT
HHHHHHHHHHHHHHH		17322306
709PhosphorylationLMPQVLTTLEEDSKM
HHHHHHHHHHHCCHH		17322306
715 (in isoform 1)Ubiquitination-21890473
715UbiquitinationTTLEEDSKMTRLISC
HHHHHCCHHHHHHHH		22053931
715 (in isoform 2)Ubiquitination-21890473
721PhosphorylationSKMTRLISCRIINTF
CHHHHHHHHHHHHHH		-
727PhosphorylationISCRIINTFLKTSGG
HHHHHHHHHHHHCCC		20068231
730 (in isoform 1)Ubiquitination-21890473
730UbiquitinationRIINTFLKTSGGMTD
HHHHHHHHHCCCCCC		21906983
730 (in isoform 2)Ubiquitination-21890473
731PhosphorylationIINTFLKTSGGMTDP
HHHHHHHHCCCCCCH		-
732PhosphorylationINTFLKTSGGMTDPE
HHHHHHHCCCCCCHH		-
740UbiquitinationGGMTDPEKLIRIYPE
CCCCCHHHHHHHHHH		21906983
743 (in isoform 2)Ubiquitination-21890473
743 (in isoform 1)Ubiquitination-21890473
750 (in isoform 2)Ubiquitination-21890473
750 (in isoform 1)Ubiquitination-21890473
750UbiquitinationRIYPELLKRLDDVSN
HHHHHHHHHHHHCCH		2190698
756PhosphorylationLKRLDDVSNDVRMAA
HHHHHHCCHHHHHHH		26657352
775UbiquitinationVTWLQCVKGANAKSY
HHHHHHHCCCCCHHH		-
780UbiquitinationCVKGANAKSYYQSSV
HHCCCCCHHHHHHHH		-
781PhosphorylationVKGANAKSYYQSSVQ
HCCCCCHHHHHHHHH		28152594
782PhosphorylationKGANAKSYYQSSVQY
CCCCCHHHHHHHHHH		28152594
783PhosphorylationGANAKSYYQSSVQYL
CCCCHHHHHHHHHHH		28152594
785PhosphorylationNAKSYYQSSVQYLYR
CCHHHHHHHHHHHHH		20071362
786PhosphorylationAKSYYQSSVQYLYRE
CHHHHHHHHHHHHHH		28152594
789PhosphorylationYYQSSVQYLYRELLV
HHHHHHHHHHHHHHH		28152594
791PhosphorylationQSSVQYLYRELLVHL
HHHHHHHHHHHHHHC		28152594
817PhosphorylationLEVLKEGSGLFPDLL
HHHHHHCCCCCCHHH		30622161
834 (in isoform 2)Phosphorylation-28387310
834UbiquitinationETEAVIHKHRSATYC
CCHHHHHHHCCHHHH		-
837PhosphorylationAVIHKHRSATYCEQL
HHHHHHCCHHHHHHH		25693802
839PhosphorylationIHKHRSATYCEQLLQ
HHHHCCHHHHHHHHH		25693802
840PhosphorylationHKHRSATYCEQLLQH
HHHCCHHHHHHHHHH		25693802
843 (in isoform 2)Phosphorylation-28387310
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DAAF5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DAAF5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DAAF5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FEZ1_HUMANFEZ1physical
16169070
ZBT16_HUMANZBTB16physical
16169070
ARP3_HUMANACTR3physical
22863883
HNRPF_HUMANHNRNPFphysical
22863883
2AAA_HUMANPPP2R1Aphysical
22863883
DNAI2_HUMANDNAI2physical
25232951
ARBK1_HUMANADRBK1physical
26344197
FLNA_HUMANFLNAphysical
26344197
GFPT1_HUMANGFPT1physical
26344197
RIR2_HUMANRRM2physical
26344197
XPO6_HUMANXPO6physical
26344197
STOM_HUMANSTOMphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614874Ciliary dyskinesia, primary, 18 (CILD18)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DAAF5_HUMAN

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Related Literatures of Post-Translational Modification

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