DNAI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNAI2_HUMAN
• UniProt AC: Q9GZS0
• Protein Name: Dynein intermediate chain 2, axonemal
• Gene Name: DNAI2
• Organism: Homo sapiens (Human).
• Sequence Length: 605
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme.
• Protein Description: Part of the dynein complex of respiratory cilia..
• Protein Sequence: MEIVYVYVKKRSEFGKQCNFSDRQAELNIDIMPNPELAEQFVERNPVDTGIQCSISMSEHEANSERFEMETRGVNHVEGGWPKDVNPLELEQTIRFRKKVEKDENYVNAIMQLGSIMEHCIKQNNAIDIYEEYFNDEEAMEVMEEDPSAKTINVFRDPQEIKRAATHLSWHPDGNRKLAVAYSCLDFQRAPVGMSSDSYIWDLENPNKPELALKPSSPLVTLEFNPKDSHVLLGGCYNGQIACWDTRKGSLVAELSTIESSHRDPVYGTIWLQSKTGTECFSASTDGQVMWWDIRKMSEPTEVVILDITKKEQLENALGAISLEFESTLPTKFMVGTEQGIVISCNRKAKTSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTVGDWTARIWSEDSRESSIMWTKYHMAYLTDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQCDPTLSLKVCDEALFCLRVQDNGCLIACGSQLGTTTLLEVSPGLSTLQRNEKNVASSMFERETRREKILEARHREMRLKEKGKAEGRDEEQTDEELAVDLEALVSKAEEEFFDIIFAELKKKEADAIKLTPVPQQPSPEEDQVVEEGEEAAGEEGDEEVEEDLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
182	Phosphorylation	NRKLAVAYSCLDFQR CCEEEEEEECCCCCC	8.04	25693802
183	Phosphorylation	RKLAVAYSCLDFQRA CEEEEEEECCCCCCC	9.85	25693802
195	Phosphorylation	QRAPVGMSSDSYIWD CCCCCCCCCCCEEEE	25.68	28122231
196	Phosphorylation	RAPVGMSSDSYIWDL CCCCCCCCCCEEEEC	22.99	28122231
198	Phosphorylation	PVGMSSDSYIWDLEN CCCCCCCCEEEECCC	22.07	28122231
199	Phosphorylation	VGMSSDSYIWDLENP CCCCCCCEEEECCCC	15.83	28122231
298	Phosphorylation	WWDIRKMSEPTEVVI EEEHHHCCCCCEEEE	43.38	-
301	Phosphorylation	IRKMSEPTEVVILDI HHHCCCCCEEEEEEC	37.04	-
331	Phosphorylation	EFESTLPTKFMVGTE EEECCCCCEEEEECC	39.77	-
337	Phosphorylation	PTKFMVGTEQGIVIS CCEEEEECCEEEEEE	17.45	-
344	Phosphorylation	TEQGIVISCNRKAKT CCEEEEEECCCCCCC	8.41	-
395	Phosphorylation	ARIWSEDSRESSIMW EEECCCCCCCCCCEE	33.62	30622161
398	Phosphorylation	WSEDSRESSIMWTKY CCCCCCCCCCEEEEH	24.85	30622161
399	Phosphorylation	SEDSRESSIMWTKYH CCCCCCCCCEEEEHH	16.23	30622161
405	Phosphorylation	SSIMWTKYHMAYLTD CCCEEEEHHHHHHCC	6.88	22817900
409	Phosphorylation	WTKYHMAYLTDAAWS EEEHHHHHHCCCCCC	11.54	22817900
520	Acetylation	RHREMRLKEKGKAEG HHHHHHHHHHCCCCC	47.19	156889
522	Acetylation	REMRLKEKGKAEGRD HHHHHHHHCCCCCCC	65.21	20167786

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNAI2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNAI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNAI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SQSTM_HUMAN	SQSTM1	physical	25015291
TCPB_HUMAN	CCT2	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
STIP1_HUMAN	STIP1	physical	28514442
TCPE_HUMAN	CCT5	physical	28514442
TCPH_HUMAN	CCT7	physical	28514442
TCPW_HUMAN	CCT6B	physical	28514442
TCPA_HUMAN	TCP1	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442
MYO1D_HUMAN	MYO1D	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 612444: Ciliary dyskinesia, primary, 9 (CILD9)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.