HEAT3_HUMAN - dbPTM
HEAT3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HEAT3_HUMAN
UniProt AC Q7Z4Q2
Protein Name HEAT repeat-containing protein 3
Gene Name HEATR3
Organism Homo sapiens (Human).
Sequence Length 680
Subcellular Localization
Protein Description
Protein Sequence MGKSRTKRFKRPQFSPTGDCQAEAAAAANGTGGEEDDGPAAELLEKLQHPSAEVRECACAGLARLVQQRPALPGLARRDAVRRLGPLLLDPSLAVRETAAGALRNLSACGGFEVCDDMVTKDIMTPLVALLKECSAGLDSNEMSLQEKKDQNRNSIENIANETVNVLWNICECSSRAVSIFNKEGCLEIVLKYLSRFPTNVDLAISVAYCLQTVTEDNPELLKSFSATALNMLESALLSPVSSMESLLLKTLVAGTIWNLKDIIPCKSQAEIINALLKILSEVLGMDAGEMVIQMKEAETQRLKTAAEAEEILENTNGDDLIEDDEMEGISHKRRVRRKTFVSDLLPPTDKELRETIALLTAQQTALEIIVNMCCNEDPSDDEWEELSSSDESDAFMENSFSECGGQLFSPLCLSHEVHTALTNYLIPKKIFEKTAFPNSIAVDLCSRNPTWKPLIRKMNTIQCRALFCLQSLVSLLDVEHLGGAAALQTLAQHLSQLLFSQPDFAKHVDFLEAISSALRALLQTMASKNISQCMTPDQLMTLCKAGIHSSNVGVRVNVVSILGITGSVLAKEDGTLETLKNIGCFLLEVTTKDPSLVVAGEALDALFDVFADGKEAERASIQIKLLSALKEFQPVFKMKIRKEGRGNYSTDQLCVLDNVKMNLRRFIAYQETVEKRLTS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationRFKRPQFSPTGDCQA
CCCCCCCCCCCCHHH		19.1223401153
17PhosphorylationKRPQFSPTGDCQAEA
CCCCCCCCCCHHHHH		44.4430278072
31PhosphorylationAAAAANGTGGEEDDG
HHHHHCCCCCCCCCC		41.6528464451
31UbiquitinationAAAAANGTGGEEDDG
HHHHHCCCCCCCCCC		41.6532015554
36UbiquitinationNGTGGEEDDGPAAEL
CCCCCCCCCCHHHHH		62.9629967540
120PhosphorylationEVCDDMVTKDIMTPL
CCCCCCCCCCCHHHH		19.16-
125PhosphorylationMVTKDIMTPLVALLK
CCCCCCHHHHHHHHH		17.5020068231
135PhosphorylationVALLKECSAGLDSNE
HHHHHHHHCCCCCCC		26.85-
143SulfoxidationAGLDSNEMSLQEKKD
CCCCCCCCCHHHHHH		5.9221406390
144PhosphorylationGLDSNEMSLQEKKDQ
CCCCCCCCHHHHHHH		22.26-
148AcetylationNEMSLQEKKDQNRNS
CCCCHHHHHHHCHHH		49.0026051181
148UbiquitinationNEMSLQEKKDQNRNS
CCCCHHHHHHHCHHH		49.0032015554
150UbiquitinationMSLQEKKDQNRNSIE
CCHHHHHHHCHHHHH		63.1529967540
195PhosphorylationEIVLKYLSRFPTNVD
HHHHHHHHCCCCCHH		28.8726074081
199PhosphorylationKYLSRFPTNVDLAIS
HHHHCCCCCHHHHHH		45.2026074081
206PhosphorylationTNVDLAISVAYCLQT
CCHHHHHHHHHHHHH		8.6226074081
209PhosphorylationDLAISVAYCLQTVTE
HHHHHHHHHHHHCCC		7.4926074081
213PhosphorylationSVAYCLQTVTEDNPE
HHHHHHHHCCCCCHH		19.2226074081
215PhosphorylationAYCLQTVTEDNPELL
HHHHHHCCCCCHHHH		40.8026074081
246PhosphorylationSPVSSMESLLLKTLV
CCCCCHHHHHHHHHH		18.71-
267UbiquitinationLKDIIPCKSQAEIIN
HHHHCCCCCHHHHHH		40.0029967540
268PhosphorylationKDIIPCKSQAEIINA
HHHCCCCCHHHHHHH		41.1421712546
300PhosphorylationIQMKEAETQRLKTAA
EHHHHHHHHHHHHHH		26.4920058876
340PhosphorylationKRRVRRKTFVSDLLP
HHHHCCHHHHHHCCC		27.7029255136
343PhosphorylationVRRKTFVSDLLPPTD
HCCHHHHHHCCCCCC		20.5323403867
349PhosphorylationVSDLLPPTDKELRET
HHHCCCCCCHHHHHH		58.7323312004
394UbiquitinationLSSSDESDAFMENSF
HCCCCCHHHHHHCCH		41.6029967540
400UbiquitinationSDAFMENSFSECGGQ
HHHHHHCCHHHCCCC		19.4921890473
430UbiquitinationTNYLIPKKIFEKTAF
HHCCCCHHHHHCCCC		47.4729967540
445UbiquitinationPNSIAVDLCSRNPTW
CCCCHHHHHHCCCCC		1.9929967540
508UbiquitinationSQPDFAKHVDFLEAI
CCHHHHHHHHHHHHH		22.4329967540
514UbiquitinationKHVDFLEAISSALRA
HHHHHHHHHHHHHHH		14.7621890473
544UbiquitinationPDQLMTLCKAGIHSS
HHHHHHHHHHCCCCC		1.7729967540
545 (in isoform 2)Ubiquitination-53.4021890473
545UbiquitinationDQLMTLCKAGIHSSN
HHHHHHHHHCCCCCC		53.4021890473
545AcetylationDQLMTLCKAGIHSSN
HHHHHHHHHCCCCCC		53.4026051181
550PhosphorylationLCKAGIHSSNVGVRV
HHHHCCCCCCCCCEE		22.9920068231
551PhosphorylationCKAGIHSSNVGVRVN
HHHCCCCCCCCCEEE		22.7520068231
559UbiquitinationNVGVRVNVVSILGIT
CCCCEEEEEEEEEEC		3.0629967540
561PhosphorylationGVRVNVVSILGITGS
CCEEEEEEEEEECCC		14.07-
625UbiquitinationERASIQIKLLSALKE
HHHHHHHHHHHHHHH		27.3129967540
631UbiquitinationIKLLSALKEFQPVFK
HHHHHHHHHHHHHEE		57.0822817900
631 (in isoform 1)Ubiquitination-57.0821890473
661UbiquitinationLCVLDNVKMNLRRFI
EEEEHHHHHHHHHHH		28.4629967540
676UbiquitinationAYQETVEKRLTS---
HHHHHHHHHHCC---		48.6629967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HEAT3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HEAT3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HEAT3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HEAT3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HEAT3_HUMAN

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Related Literatures of Post-Translational Modification

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