ANM9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANM9_HUMAN
• UniProt AC: Q6P2P2
• Protein Name: Protein arginine N-methyltransferase 9
• Gene Name: PRMT9 {ECO:0000312|HGNC:HGNC:25099}
• Organism: Homo sapiens (Human).
• Sequence Length: 845
• Subcellular Localization: Cytoplasm .
• Protein Description: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA. [PubMed: 25737013]
• Protein Sequence: MSNSRPRSRRDAGGGAGAAGRDELVSRSLQSAEHCLGVQDFGTAYAHYLLVLSLAPELKHDVKETFQYTLFRWAEELDALSRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNAAIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEETIEPYTTEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLADYWIKPGDHVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALLNNIPYHEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLISEANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTLLEENAVQGTERTLGLNIAPFINQFQVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEIRLDTSSEASHWKQAAVVLDNPIQVEMGEELVLSIQHHKSNVSITVKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSNSRPRSR ------CCCCCCCCC		24719451
8	Phosphorylation	MSNSRPRSRRDAGGG CCCCCCCCCCCCCCC		24719451
13	Ubiquitination	PRSRRDAGGGAGAAG CCCCCCCCCCCCCCC		-
16	Ubiquitination	RRDAGGGAGAAGRDE CCCCCCCCCCCCHHH		27667366
16	Ubiquitination	RRDAGGGAGAAGRDE CCCCCCCCCCCCHHH		-
25	Ubiquitination	AAGRDELVSRSLQSA CCCHHHHHHHHHHHH		-
25	Ubiquitination	AAGRDELVSRSLQSA CCCHHHHHHHHHHHH		29967540
48	Ubiquitination	FGTAYAHYLLVLSLA HHHHHHHHHHHHHHC		-
51	Ubiquitination	AYAHYLLVLSLAPEL HHHHHHHHHHHCHHH		21963094
59	Ubiquitination	LSLAPELKHDVKETF HHHCHHHCCCHHHHH		-
84	Ubiquitination	LDALSRIQDLLGCYE HHHHHHHHHHHHHHH		-
84	Ubiquitination	LDALSRIQDLLGCYE HHHHHHHHHHHHHHH		29967540
111	Ubiquitination	CNSMGEHLFRMGFRD ECCCHHHHHHCCCCH		-
117	Ubiquitination	HLFRMGFRDEAAGYF HHHHCCCCHHHHHHH		-
117	Ubiquitination	HLFRMGFRDEAAGYF HHHHCCCCHHHHHHH		22817900
122	Ubiquitination	GFRDEAAGYFHKAVK CCCHHHHHHHHHEEC		-
122	Ubiquitination	GFRDEAAGYFHKAVK CCCHHHHHHHHHEEC		21963094
126	Ubiquitination	EAAGYFHKAVKLNPD HHHHHHHHEECCCCC		-
129	Ubiquitination	GYFHKAVKLNPDFSD HHHHHEECCCCCCHH		27667366
135	Phosphorylation	VKLNPDFSDAKENFY ECCCCCCHHHHHHHH		29743597
138	Ubiquitination	NPDFSDAKENFYRVA CCCCHHHHHHHHHHH		29967540
161	Ubiquitination	FIMLNDTKRNTIYNA EEECCCCCCCHHHHH		-
164	Phosphorylation	LNDTKRNTIYNAAIQ CCCCCCCHHHHHHHH		30622161
166	Phosphorylation	DTKRNTIYNAAIQKA CCCCCHHHHHHHHHH		30622161
172	Ubiquitination	IYNAAIQKAVCLGSK HHHHHHHHHHHCCCC		-
192	Phosphorylation	GAGTGILSMFAKKAG CCCCCHHHHHHHHHC		-
197	Ubiquitination	ILSMFAKKAGAHSVY HHHHHHHHHCCCEEE		29967540
209	Ubiquitination	SVYACELSKTMYELA EEEEHHHCHHHHHHH		-
221	Ubiquitination	ELACDVVAANKMEAG HHHHHHHHHCHHHHC		29967540
224	Ubiquitination	CDVVAANKMEAGIKL HHHHHHCHHHHCEEE		-
230	Ubiquitination	NKMEAGIKLLHTKSL CHHHHCEEEEEECCC		22817900
235 (in isoform 1)	Ubiquitination	-		21906983
235	Ubiquitination	GIKLLHTKSLDIEIP CEEEEEECCCCEECC		21906983
236	Phosphorylation	IKLLHTKSLDIEIPK EEEEEECCCCEECCC		28348404
243	Ubiquitination	SLDIEIPKHIPERVS CCCEECCCCCCCCEE		21963094
243	Ubiquitination	SLDIEIPKHIPERVS CCCEECCCCCCCCEE		-
277	Ubiquitination	LIHAWEHLLLQPKTK HHHHHHHHHCCCCCC		29967540
322	Ubiquitination	RHHRVGIKDIAGIHL HHHCCCCCCCCCCCC		-
334	Ubiquitination	IHLPTNVKFQSPAYS CCCCCCCCCCCCCCC		29967540
337	Phosphorylation	PTNVKFQSPAYSSVD CCCCCCCCCCCCCCC		-
348	Phosphorylation	SSVDTEETIEPYTTE CCCCCCCCCCCCCCH		-
356 (in isoform 1)	Ubiquitination	-		21906983
356	Ubiquitination	IEPYTTEKMSRVPGG CCCCCCHHHHCCCCC		21963094
390	Ubiquitination	ELKSLATKKPDKIGI HHHHHHCCCCCCCCC		29967540
447	Ubiquitination	QDLADYWIKPGDHVM HHHHHHCCCCCCEEE		21987572
538	Ubiquitination	IPYHEGFKMAMSKVL CCCCHHHHHHHHHHH		29967540
547	Phosphorylation	AMSKVLSSLTPEKLY HHHHHHHHCCHHHHH		28348404
549	Phosphorylation	SKVLSSLTPEKLYQT HHHHHHCCHHHHHHH		23312004
639	Ubiquitination	TLEFWLRHVEDESAM HHHHHHHHCCCHHHH		21987572
639	Ubiquitination	TLEFWLRHVEDESAM HHHHHHHHCCCHHHH		-
651	Ubiquitination	SAMLQRPKSDKLWSI HHHHCCCCCCCCEEE		29967540
652	Phosphorylation	AMLQRPKSDKLWSII HHHCCCCCCCCEEEE		29116813
717	Phosphorylation	EENAVQGTERTLGLN HHHCCCCCCCCCCCC		-
743	Phosphorylation	IRVFLDLSSLPCIPL EEEEECCCCCCCEEC		23663014
744	Phosphorylation	RVFLDLSSLPCIPLS EEEECCCCCCCEECC		23663014
751	Phosphorylation	SLPCIPLSKPVELLR CCCCEECCCCHHHHH		23663014
752	Ubiquitination	LPCIPLSKPVELLRL CCCEECCCCHHHHHH		21987572
779	Acetylation	EVKVYVCKSGRLTAI EEEEEEECCCCCCEE		25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANM9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANM9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANM9_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ANM9_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.