| UniProt ID | MIGA1_HUMAN | |
|---|---|---|
| UniProt AC | Q8NAN2 | |
| Protein Name | Mitoguardin 1 {ECO:0000303|PubMed:26711011} | |
| Gene Name | MIGA1 {ECO:0000303|PubMed:26711011, ECO:0000312|HGNC:HGNC:24741} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 632 | |
| Subcellular Localization |
Mitochondrion outer membrane Single-pass membrane protein . |
|
| Protein Description | Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD.. | |
| Protein Sequence | MSDCCSAPGISWEAGVGRPAVPGLELQIRRGAMSEETVSESQFSLKTAALRVFDLPLTWYYSLSQIKFSPVAKKLFVVTAVSAISVIFLAHHFKRKRGKKKGKILPWEPEHLILEYTKRAASDKGSSCSSSRQNLTLSLSSTKDKGSQVCNYANGGLFSKYSGSAQSLASVQSVNSCHSCACGNSNSWDKADEDDIKLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRNRQAEDEACGSIKLGAGDAIAEENVDDIISTEFIHKLEALLQRAYRLQEEFEATLGASDPNSLADDIDKDTDITMKGNVEDFGLRDTLSIASTDSFASAAELAEHREVRHTYSLESLCHCPFYEEAMHLVEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQVILSESANRIFLAESGRKILSALIVKARKNPKKFEDVFDEMIYFLEQTDHWGSTEMELAARGVKNLNFYDVVLDFILMDSFEDLENPPTSIQNVVNNRWLNSSFKETAVASSCWSVLKQKRQQMKIPDGFFAHFYAICEHISPVLAWGFLGPRNSLYDLCCFFKNQVLLFLKDIFDFEKVRYSSTETLAEDLMQLLIRRTELLMAYLEADALRHTSSCLSSHGHVMSTGLLEAKVQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 61 | Phosphorylation | DLPLTWYYSLSQIKF CCCHHEEEEHHHCCC | - | ||
| 62 | Phosphorylation | LPLTWYYSLSQIKFS CCHHEEEEHHHCCCC | - | ||
| 64 | Phosphorylation | LTWYYSLSQIKFSPV HHEEEEHHHCCCCHH | 24719451 | ||
| 103 | Ubiquitination | KRGKKKGKILPWEPE HCCCCCCCCCCCCCH | - | ||
| 126 | Phosphorylation | RAASDKGSSCSSSRQ HHHHCCCCCCCCCCC | 27251275 | ||
| 127 | Phosphorylation | AASDKGSSCSSSRQN HHHCCCCCCCCCCCC | 27251275 | ||
| 129 | Phosphorylation | SDKGSSCSSSRQNLT HCCCCCCCCCCCCEE | 27251275 | ||
| 130 | Phosphorylation | DKGSSCSSSRQNLTL CCCCCCCCCCCCEEE | 27251275 | ||
| 131 | Phosphorylation | KGSSCSSSRQNLTLS CCCCCCCCCCCEEEE | 28857561 | ||
| 136 | Phosphorylation | SSSRQNLTLSLSSTK CCCCCCEEEEEECCC | 22199227 | ||
| 138 | Phosphorylation | SRQNLTLSLSSTKDK CCCCEEEEEECCCCC | 22199227 | ||
| 140 | Phosphorylation | QNLTLSLSSTKDKGS CCEEEEEECCCCCCC | 22199227 | ||
| 141 | Phosphorylation | NLTLSLSSTKDKGSQ CEEEEEECCCCCCCC | 22199227 | ||
| 142 | Phosphorylation | LTLSLSSTKDKGSQV EEEEEECCCCCCCCC | 22199227 | ||
| 147 | Phosphorylation | SSTKDKGSQVCNYAN ECCCCCCCCCCCCCC | 26657352 | ||
| 152 | Phosphorylation | KGSQVCNYANGGLFS CCCCCCCCCCCCCCC | 29449344 | ||
| 159 | Phosphorylation | YANGGLFSKYSGSAQ CCCCCCCCCCCCCCH | 24719451 | ||
| 162 | Phosphorylation | GGLFSKYSGSAQSLA CCCCCCCCCCCHHHH | 27251275 | ||
| 164 | Phosphorylation | LFSKYSGSAQSLASV CCCCCCCCCHHHHHC | 28348404 | ||
| 204 | Phosphorylation | KLVNIPVTTPENLYL EEEECCCCCHHHHHH | 24043423 | ||
| 205 | Phosphorylation | LVNIPVTTPENLYLM EEECCCCCHHHHHHH | 24043423 | ||
| 210 | Phosphorylation | VTTPENLYLMGMELF CCCHHHHHHHCHHHH | 24043423 | ||
| 242 | Phosphorylation | AEDEACGSIKLGAGD HCHHCCCCCEECCHH | 21815630 | ||
| 285 | Phosphorylation | LQEEFEATLGASDPN HHHHHHHHHCCCCCC | 30624053 | ||
| 289 | Phosphorylation | FEATLGASDPNSLAD HHHHHCCCCCCCCHH | 29743597 | ||
| 293 | Phosphorylation | LGASDPNSLADDIDK HCCCCCCCCHHHCCC | 27251275 | ||
| 368 | Phosphorylation | VEEGKIYSRVLRTEM HHCCCHHHHHHHHHH | 24719451 | ||
| 400 | Phosphorylation | QAFQVILSESANRIF HHHHHHHCCCCCCEE | - | ||
| 402 | Phosphorylation | FQVILSESANRIFLA HHHHHCCCCCCEEEE | - | ||
| 417 | Phosphorylation | ESGRKILSALIVKAR HHHHHHHHHHHHHHH | - | ||
| 498 | Phosphorylation | VNNRWLNSSFKETAV HHCCHHCCHHHHHHH | 24275569 | ||
| 514 | Ubiquitination | SSCWSVLKQKRQQMK HHHHHHHHHHHHHCC | - | ||
| 575 | Ubiquitination | KDIFDFEKVRYSSTE HHHCCHHHHCCCCHH | - | ||
| 581 | Phosphorylation | EKVRYSSTETLAEDL HHHCCCCHHHHHHHH | - | ||
| 583 | Phosphorylation | VRYSSTETLAEDLMQ HCCCCHHHHHHHHHH | - | ||
| 611 | Phosphorylation | EADALRHTSSCLSSH HHHHHHHHHHHHHHC | 25954137 | ||
| 613 | Phosphorylation | DALRHTSSCLSSHGH HHHHHHHHHHHHCCC | 25954137 | ||
| 617 | Phosphorylation | HTSSCLSSHGHVMST HHHHHHHHCCCCCCC | 25954137 | ||
| 623 | Phosphorylation | SSHGHVMSTGLLEAK HHCCCCCCCCCCEEC | 28857561 | ||
| 624 | Phosphorylation | SHGHVMSTGLLEAKV HCCCCCCCCCCEECC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MIGA1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIGA1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIGA1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MIGA1_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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