PHKG2_HUMAN - dbPTM
PHKG2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHKG2_HUMAN
UniProt AC P15735
Protein Name Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
Gene Name PHKG2
Organism Homo sapiens (Human).
Sequence Length 406
Subcellular Localization
Protein Description Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity)..
Protein Sequence MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTLDVGPED
------CCCCCCCCC		31.5028348404
18UbiquitinationLPDWAAAKEFYQKYD
CCCHHHHHHHHHHCC		43.5629967540
23UbiquitinationAAKEFYQKYDPKDVI
HHHHHHHHCCHHHCC		40.0027667366
24PhosphorylationAKEFYQKYDPKDVIG
HHHHHHHCCHHHCCC		23.19-
27UbiquitinationFYQKYDPKDVIGRGV
HHHHCCHHHCCCCCH		62.8229967540
35PhosphorylationDVIGRGVSSVVRRCV
HCCCCCHHHHHHHHH		21.90-
46O-linked_GlycosylationRRCVHRATGHEFAVK
HHHHHHHCCCCHHHH		38.7430379171
92PhosphorylationAGHPHIITLIDSYES
CCCCCEEEEEECCCC		19.6328122231
96PhosphorylationHIITLIDSYESSSFM
CEEEEEECCCCCCHH		24.6528122231
97PhosphorylationIITLIDSYESSSFMF
EEEEEECCCCCCHHH		18.9728122231
99PhosphorylationTLIDSYESSSFMFLV
EEEECCCCCCHHHHH		24.0528122231
100PhosphorylationLIDSYESSSFMFLVF
EEECCCCCCHHHHHH		18.6928122231
101PhosphorylationIDSYESSSFMFLVFD
EECCCCCCHHHHHHH		29.9728122231
122UbiquitinationLFDYLTEKVALSEKE
HHHHHHHHHCCCHHH		27.80-
128UbiquitinationEKVALSEKETRSIMR
HHHCCCHHHHHHHHH		62.0927667366
155UbiquitinationNIVHRDLKPENILLD
CCCCCCCCHHHEEEC		55.3522817900
175PhosphorylationRLSDFGFSCHLEPGE
EHHHCCCCCCCCCCH		10.8728857561
183UbiquitinationCHLEPGEKLRELCGT
CCCCCCHHHHHHHCC		59.78-
190PhosphorylationKLRELCGTPGYLAPE
HHHHHHCCCCCHHHH		16.7321815630
303PhosphorylationGSQPWNLTPRQRFRV
CCCCCCCCHHHHHHH		17.1424719451
324PhosphorylationAAGRVALSTHRVRPL
HCHHHHHHCCCCCCC		16.6618691976
325PhosphorylationAGRVALSTHRVRPLT
CHHHHHHCCCCCCCC		17.9828857561
333MalonylationHRVRPLTKNALLRDP
CCCCCCCHHHHHCCH		48.1626320211
341PhosphorylationNALLRDPYALRSVRH
HHHHCCHHHHHHHHH		23.6623186163
345PhosphorylationRDPYALRSVRHLIDN
CCHHHHHHHHHHHHH		25.098896567
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHKG2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHKG2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHKG2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NDUA4_HUMANNDUFA4physical
23455922
SCO2_HUMANSCO2physical
23455922
VDAC2_HUMANVDAC2physical
23455922
KPB2_HUMANPHKA2physical
23455922
KPB1_HUMANPHKA1physical
23455922
FAS_HUMANFASNphysical
23455922
PSA_HUMANNPEPPSphysical
23455922
PRKDC_HUMANPRKDCphysical
23455922
ACACA_HUMANACACAphysical
23455922
ATD3C_HUMANATAD3Cphysical
23455922
ZC3HF_HUMANZC3H15physical
23455922
GCN1_HUMANGCN1L1physical
23455922
TNPO1_HUMANTNPO1physical
23455922
YMEL1_HUMANYME1L1physical
23455922
ATD3A_HUMANATAD3Aphysical
23455922
CHIP_HUMANSTUB1physical
23455922
DRG1_HUMANDRG1physical
23455922
BZW2_HUMANBZW2physical
23455922
GAK_HUMANGAKphysical
26496610
LAMC1_HUMANLAMC1physical
26496610
PEX10_HUMANPEX10physical
26496610
KPB1_HUMANPHKA1physical
26496610
KPB2_HUMANPHKA2physical
26496610
KPBB_HUMANPHKBphysical
26496610
TF3C5_HUMANGTF3C5physical
26496610
HPS5_HUMANHPS5physical
26496610
CLAP1_HUMANCLASP1physical
26496610
CENPV_HUMANCENPVphysical
26496610
NSUN4_HUMANNSUN4physical
26496610
H3C_HUMANH3F3Cphysical
26496610
KPB1_HUMANPHKA1physical
28514442
PHKG1_HUMANPHKG1physical
28514442
KPB2_HUMANPHKA2physical
28514442
KPBB_HUMANPHKBphysical
28514442
CE85L_HUMANCEP85Lphysical
28514442
AAPK1_HUMANPRKAA1physical
28514442
AAKB2_HUMANPRKAB2physical
28514442
AAKB1_HUMANPRKAB1physical
28514442
AAKG1_HUMANPRKAG1physical
28514442
F171B_HUMANFAM171Bphysical
28514442
SETB1_HUMANSETDB1physical
28514442
AAKG2_HUMANPRKAG2physical
28514442
EMAL4_HUMANEML4physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613027Glycogen storage disease 9C (GSD9C)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHKG2_HUMAN

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Related Literatures of Post-Translational Modification

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