dbPTM

F171B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	F171B_HUMAN
UniProt AC	Q6P995
Protein Name	Protein FAM171B
Gene Name	FAM171B
Organism	Homo sapiens (Human).
Sequence Length	826
Subcellular Localization	Membrane Single-pass type I membrane protein .
Protein Description
Protein Sequence	MARLCRRVPCTLLLGLAVVLLKARLVPAAARAELSRSDLSLIQQQQQQQQQQQQQQKQLEEAEEERTEVPGATSTLTVPVSVFMLKVQVNDIISRQYLSQAVVEVFVNYTKTNSTVTKSNGAVLIKVPYKLGLSLTIIAYKDGYVLTPLPWKTRRMPIYSSVTLSLFPQSQANIWLFEDTVLITGKLADAKSQPSVQFSKALIKLPDNHHISNVTGYLTVLQQFLKVDNFLHTTGITLNKPGFENIELTPLAAICVKIYSGGKELKVNGSIQVSLPLLRLNDISAGDRIPAWTFDMNTGAWVNHGRGMVKEHNNHLIWTYDAPHLGYWIAAPLPGTRGSGINEDSKDITAYHTVFLTAILGGTIVIVIGFFAVLLCYCRDKCGTPQKRERNITKLEVLKRDQTTSTTHINHISTVKVALKAEDKSQLFNAKNSSYSPQKKEPSKAETEERVSMVKTRDDFKIYNEDVSFLSVNQNNYSRNPTQSLEPNVGSKQPKHINNNLSSSLGDAQDEKRYLTGNEEAYGRSHIPEQLMHIYSQPIAILQTSDLFSTPEQLHTAKSATLPRKGQLVYGQLMEPVNRENFTQTLPKMPIHSHAQPPDAREEDIILEGQQSLPSQASDWSRYSSSLLESVSVPGTLNEAVVMTPFSSELQGISEQTLLELSKGKPSPHPRAWFVSLDGKPVAQVRHSFIDLKKGKRTQSNDTSLDSGVDMNELHSSRKLEREKTFIKSMHQPKILYLEDLDLSSSESGTTVCSPEDPALRHILDGGSGVIMEHPGEESPGRKSTVEDFEANTSPTKRRGRPPLAKRDSKTNIWKKREERPLIPIN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
108	N-linked_Glycosylation	AVVEVFVNYTKTNST HHHHHEEECCCCCCE	27.56	UniProtKB CARBOHYD
113	N-linked_Glycosylation	FVNYTKTNSTVTKSN EEECCCCCCEEEECC	36.92	UniProtKB CARBOHYD
114	Phosphorylation	VNYTKTNSTVTKSNG EECCCCCCEEEECCC	29.50	23898821
115	Phosphorylation	NYTKTNSTVTKSNGA ECCCCCCEEEECCCE	33.97	23898821
153	Phosphorylation	LTPLPWKTRRMPIYS EECCCCCCCCCCCCE	21.46	23403867
184	Phosphorylation	FEDTVLITGKLADAK EECEEEEECCCCCCC	24.89	23403867
192	Phosphorylation	GKLADAKSQPSVQFS CCCCCCCCCCCCEEE	49.39	23403867
195	Phosphorylation	ADAKSQPSVQFSKAL CCCCCCCCCEEEEEH	22.40	23403867
199	Phosphorylation	SQPSVQFSKALIKLP CCCCCEEEEEHHCCC	10.42	23403867
213	N-linked_Glycosylation	PDNHHISNVTGYLTV CCCCCCCCHHHHHHH	34.46	UniProtKB CARBOHYD
268	N-linked_Glycosylation	GGKELKVNGSIQVSL CCEEEEECCEEEEEE	36.59	UniProtKB CARBOHYD
393	Phosphorylation	QKRERNITKLEVLKR CHHCCCCCEEEEEEC	32.88	23312004
394	Ubiquitination	KRERNITKLEVLKRD HHCCCCCEEEEEECC	38.56	33845483
403	Phosphorylation	EVLKRDQTTSTTHIN EEEECCCCCCCEEEC	27.31	23403867
404	Phosphorylation	VLKRDQTTSTTHINH EEECCCCCCCEEECE	20.60	26657352
405	Phosphorylation	LKRDQTTSTTHINHI EECCCCCCCEEECEE	34.39	25849741
406	Phosphorylation	KRDQTTSTTHINHIS ECCCCCCCEEECEEE	21.94	26657352
407	Phosphorylation	RDQTTSTTHINHIST CCCCCCCEEECEEEE	22.11	23403867
413	Phosphorylation	TTHINHISTVKVALK CEEECEEEEEEEEEE	21.43	23403867
414	Phosphorylation	THINHISTVKVALKA EEECEEEEEEEEEEC	24.60	23403867
424	Ubiquitination	VALKAEDKSQLFNAK EEEECCCHHHHHCCC	31.44	30230243
425	Phosphorylation	ALKAEDKSQLFNAKN EEECCCHHHHHCCCC	44.42	-
433	Phosphorylation	QLFNAKNSSYSPQKK HHHCCCCCCCCCCCC	29.91	23312004
434	Phosphorylation	LFNAKNSSYSPQKKE HHCCCCCCCCCCCCC	38.74	23312004
435	Phosphorylation	FNAKNSSYSPQKKEP HCCCCCCCCCCCCCC	24.96	23312004
436	Phosphorylation	NAKNSSYSPQKKEPS CCCCCCCCCCCCCCC	23.85	23312004
443	Phosphorylation	SPQKKEPSKAETEER CCCCCCCCCHHHHHH	45.66	23312004
447	Phosphorylation	KEPSKAETEERVSMV CCCCCHHHHHHHEEE	48.26	23312004
452	Phosphorylation	AETEERVSMVKTRDD HHHHHHHEEEECCCC	24.87	29514088
477	Phosphorylation	LSVNQNNYSRNPTQS EECCCCCCCCCCCCC	19.29	25884760
491	Phosphorylation	SLEPNVGSKQPKHIN CCCCCCCCCCCHHCC	24.68	30576142
495	Ubiquitination	NVGSKQPKHINNNLS CCCCCCCHHCCCCCC	55.40	30230243
502	Phosphorylation	KHINNNLSSSLGDAQ HHCCCCCCHHCCCCC	21.72	23403867
503	Phosphorylation	HINNNLSSSLGDAQD HCCCCCCHHCCCCCH	32.52	23403867
504	Phosphorylation	INNNLSSSLGDAQDE CCCCCCHHCCCCCHH	32.75	21082442
512	Ubiquitination	LGDAQDEKRYLTGNE CCCCCHHHHHHCCCH	55.41	30230243
514	Phosphorylation	DAQDEKRYLTGNEEA CCCHHHHHHCCCHHH	21.49	27642862
522	Phosphorylation	LTGNEEAYGRSHIPE HCCCHHHHCCCCCCH	19.15	25884760
561	Phosphorylation	LHTAKSATLPRKGQL HCCCCCCCCCCCCCE	44.37	24719451
565	Ubiquitination	KSATLPRKGQLVYGQ CCCCCCCCCCEEEEE	49.41	30230243
570	Phosphorylation	PRKGQLVYGQLMEPV CCCCCEEEEEECCCC	14.03	25884760
583	Phosphorylation	PVNRENFTQTLPKMP CCCCCCCCCCCCCCC	32.02	25850435
585	Phosphorylation	NRENFTQTLPKMPIH CCCCCCCCCCCCCCC	41.80	29255136
688	Phosphorylation	PVAQVRHSFIDLKKG EEEEEEEEEEECCCC	17.21	23312004
725	Phosphorylation	RKLEREKTFIKSMHQ HHHHHHHHHHHHCCC	26.32	29514088
737	Phosphorylation	MHQPKILYLEDLDLS CCCCEEEEEEECCCC	16.12	22468782
745	Phosphorylation	LEDLDLSSSESGTTV EEECCCCCCCCCCEE	45.48	22468782
750	Phosphorylation	LSSSESGTTVCSPED CCCCCCCCEEECCCC	25.90	24076635
751	Phosphorylation	SSSESGTTVCSPEDP CCCCCCCEEECCCCH	24.04	22468782
754	Phosphorylation	ESGTTVCSPEDPALR CCCCEEECCCCHHHH	27.30	24076635
768	Phosphorylation	RHILDGGSGVIMEHP HHHHHCCCCCEEECC	35.10	27732954
779	Phosphorylation	MEHPGEESPGRKSTV EECCCCCCCCCCCCH	28.49	17081983
781	Phosphorylation	HPGEESPGRKSTVED CCCCCCCCCCCCHHH	59.95	17081983
784	Phosphorylation	EESPGRKSTVEDFEA CCCCCCCCCHHHHHH	36.00	23312004
785	Phosphorylation	ESPGRKSTVEDFEAN CCCCCCCCHHHHHHC	30.83	29255136
793	Phosphorylation	VEDFEANTSPTKRRG HHHHHHCCCCCCCCC	43.03	30266825
794	Phosphorylation	EDFEANTSPTKRRGR HHHHHCCCCCCCCCC	30.31	29255136
796	Phosphorylation	FEANTSPTKRRGRPP HHHCCCCCCCCCCCC	36.63	29255136
809	Phosphorylation	PPLAKRDSKTNIWKK CCCCCCCCCCCCCCC	45.47	29496963
811	Phosphorylation	LAKRDSKTNIWKKRE CCCCCCCCCCCCCCC	35.57	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of F171B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of F171B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of F171B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPP3_HUMAN	MPP3	physical	21988832
F1711_HUMAN	FAM171A1	physical	28514442
F1712_HUMAN	FAM171A2	physical	28514442
CO4A_HUMAN	C4A	physical	28514442
FGFR2_HUMAN	FGFR2	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
STX6_HUMAN	STX6	physical	28514442
MFAP3_HUMAN	MFAP3	physical	28514442
MIB1_HUMAN	MIB1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of F171B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-779, AND MASSSPECTROMETRY.	17081983 [Abstract]