F1711_HUMAN - dbPTM
F1711_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID F1711_HUMAN
UniProt AC Q5VUB5
Protein Name Protein FAM171A1
Gene Name FAM171A1
Organism Homo sapiens (Human).
Sequence Length 890
Subcellular Localization Membrane
Single-pass type I membrane protein .
Protein Description
Protein Sequence MSRSATLLLCLLGCHVWKAVTKTLREPGAGAQEVTLKVHISDASTHQPVADALIEIFTNQASIASGTSGTDGVAFIKFQYKLGSQLIVTASKHAYVPNSAPWKPIRLPVFSSLSLGLLPERSATLMVYEDVVQIVSGFQGARPQPRVHFQRRALRLPENTSYSDLTAFLTAASSPSEVDSFPYLRGLDGNGTGNSTRHDLTPVTAVSVHLLSSNGTPVLVDGPIYVTVPLATQSSLRHNAYVAAWRFDQKLGTWLKSGLGLVHQEGSQLTWTYIAPQLGYWVAAMSPPIPGPVVTQDITTYHTVFLLAILGGMAFILLVLLCLLLYYCRRKCLKPRQHHRKLQLPAGLESSKRDQSTSMSHINLLFSRRASEFPGPLSVTSHGRPEAPGTKELMSGVHLEMMSPGGEGDLHTPMLKLSYSTSQEFSSREELLSCKEEDKSQISFDNLTPSGTLGKDYHKSVEVFPLKARKSMEREGYESSGNDDYRGSYNTVLSQPLFEKQDREGPASTGSKLTIQEHLYPAPSSPEKEQLLDRRPTECMMSRSVDHLERPTSFPRPGQLICCSSVDQVNDSVYRKVLPALVIPAHYMKLPGDHSYVSQPLVVPADQQLEIERLQAELSNPHAGIFPHPSSQIQPQPLSSQAISQQHLQDAGTREWSPQNASMSESLSIPASLNDAALAQMNSEVQLLTEKALMELGGGKPLPHPRAWFVSLDGRSNAHVRHSYIDLQRAGRNGSNDASLDSGVDMNEPKSARKGRGDALSLQQNYPPVQEHQQKEPRAPDSTAYTQLVYLDDVEQSGSECGTTVCTPEDSALRCLLEGSSRRSGGQLPSLQEETTRRTADAPSEPAASPHQRRSAHEEEEDDDDDDQGEDKKSPWQKREERPLMAFNIK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
122PhosphorylationLGLLPERSATLMVYE
CCCCCCCCEEEEEEH		24.7622817900
128PhosphorylationRSATLMVYEDVVQIV
CCEEEEEEHHHHHHH		7.7622817900
159N-linked_GlycosylationRALRLPENTSYSDLT
HCCCCCCCCCHHHHH		32.1730312582
190N-linked_GlycosylationYLRGLDGNGTGNSTR
CCCCCCCCCCCCCCC		44.51UniProtKB CARBOHYD
194N-linked_GlycosylationLDGNGTGNSTRHDLT
CCCCCCCCCCCCCCC		39.7930312582
350PhosphorylationQLPAGLESSKRDQST
CCCCCCCCCCCCCCC		46.3229507054
351PhosphorylationLPAGLESSKRDQSTS
CCCCCCCCCCCCCCC		23.4928355574
356PhosphorylationESSKRDQSTSMSHIN
CCCCCCCCCCHHHHH		27.0930266825
357PhosphorylationSSKRDQSTSMSHINL
CCCCCCCCCHHHHHH		23.8630266825
358PhosphorylationSKRDQSTSMSHINLL
CCCCCCCCHHHHHHH		24.4330266825
360PhosphorylationRDQSTSMSHINLLFS
CCCCCCHHHHHHHHH		22.4530266825
367PhosphorylationSHINLLFSRRASEFP
HHHHHHHHCCCCCCC		22.3323403867
371PhosphorylationLLFSRRASEFPGPLS
HHHHCCCCCCCCCCE		37.6527273156
378PhosphorylationSEFPGPLSVTSHGRP
CCCCCCCEECCCCCC		26.8723403867
380PhosphorylationFPGPLSVTSHGRPEA
CCCCCEECCCCCCCC		16.1923403867
381PhosphorylationPGPLSVTSHGRPEAP
CCCCEECCCCCCCCC		23.0723403867
390PhosphorylationGRPEAPGTKELMSGV
CCCCCCCCCCCCCCC		21.9323403867
395PhosphorylationPGTKELMSGVHLEMM
CCCCCCCCCCEEEEC		50.7322210691
403PhosphorylationGVHLEMMSPGGEGDL
CCEEEECCCCCCCCC		21.0529523821
418PhosphorylationHTPMLKLSYSTSQEF
CCCCEEEECCCCCCC		18.5623403867
419PhosphorylationTPMLKLSYSTSQEFS
CCCEEEECCCCCCCC		26.8025884760
420O-linked_GlycosylationPMLKLSYSTSQEFSS
CCEEEECCCCCCCCC		20.4328657654
420PhosphorylationPMLKLSYSTSQEFSS
CCEEEECCCCCCCCC		20.4330266825
421PhosphorylationMLKLSYSTSQEFSSR
CEEEECCCCCCCCCH		26.6230266825
422PhosphorylationLKLSYSTSQEFSSRE
EEEECCCCCCCCCHH		23.0519664994
426PhosphorylationYSTSQEFSSREELLS
CCCCCCCCCHHHHHC		27.9423403867
427PhosphorylationSTSQEFSSREELLSC
CCCCCCCCHHHHHCC		49.3723403867
433PhosphorylationSSREELLSCKEEDKS
CCHHHHHCCCHHHCC		35.4523312004
440PhosphorylationSCKEEDKSQISFDNL
CCCHHHCCCCCCCCC		45.1030266825
443PhosphorylationEEDKSQISFDNLTPS
HHHCCCCCCCCCCCC		20.9330266825
448PhosphorylationQISFDNLTPSGTLGK
CCCCCCCCCCCCCCC		22.9730266825
450PhosphorylationSFDNLTPSGTLGKDY
CCCCCCCCCCCCCCC		38.8930266825
452PhosphorylationDNLTPSGTLGKDYHK
CCCCCCCCCCCCCCC		36.3523403867
457PhosphorylationSGTLGKDYHKSVEVF
CCCCCCCCCCCEEEE		18.0323312004
460PhosphorylationLGKDYHKSVEVFPLK
CCCCCCCCEEEEECC		15.3630266825
477PhosphorylationKSMEREGYESSGNDD
HHHHHCCCCCCCCCC		14.1125884760
480PhosphorylationEREGYESSGNDDYRG
HHCCCCCCCCCCCCC		29.67-
485PhosphorylationESSGNDDYRGSYNTV
CCCCCCCCCCCHHHH		21.5327642862
488PhosphorylationGNDDYRGSYNTVLSQ
CCCCCCCCHHHHHCC		13.2530266825
489PhosphorylationNDDYRGSYNTVLSQP
CCCCCCCHHHHHCCC		20.0629978859
491PhosphorylationDYRGSYNTVLSQPLF
CCCCCHHHHHCCCCC		18.0030266825
494PhosphorylationGSYNTVLSQPLFEKQ
CCHHHHHCCCCCCCC		25.9730266825
508PhosphorylationQDREGPASTGSKLTI
CCCCCCCCCCCCEEE		36.1123312004
509PhosphorylationDREGPASTGSKLTIQ
CCCCCCCCCCCEEEE		47.8023532336
511PhosphorylationEGPASTGSKLTIQEH
CCCCCCCCCEEEEEE		25.2823312004
514PhosphorylationASTGSKLTIQEHLYP
CCCCCCEEEEEECCC		25.0923312004
520PhosphorylationLTIQEHLYPAPSSPE
EEEEEECCCCCCCHH		10.1530266825
524PhosphorylationEHLYPAPSSPEKEQL
EECCCCCCCHHHHHH		61.7130266825
525PhosphorylationHLYPAPSSPEKEQLL
ECCCCCCCHHHHHHH		35.7030266825
537PhosphorylationQLLDRRPTECMMSRS
HHHHCCCCCHHHCCC		39.7527251275
542PhosphorylationRPTECMMSRSVDHLE
CCCCHHHCCCCCCCC		8.4327251275
544PhosphorylationTECMMSRSVDHLERP
CCHHHCCCCCCCCCC		25.2930266825
552PhosphorylationVDHLERPTSFPRPGQ
CCCCCCCCCCCCCCC		49.5823312004
553PhosphorylationDHLERPTSFPRPGQL
CCCCCCCCCCCCCCE		35.6223312004
564PhosphorylationPGQLICCSSVDQVND
CCCEEEECCCCCCCH		29.0527732954
565PhosphorylationGQLICCSSVDQVNDS
CCEEEECCCCCCCHH		18.7927732954
572PhosphorylationSVDQVNDSVYRKVLP
CCCCCCHHHHHHHHH		18.8227732954
574PhosphorylationDQVNDSVYRKVLPAL
CCCCHHHHHHHHHHH		14.5222817900
587PhosphorylationALVIPAHYMKLPGDH
HHEEEHHHCCCCCCC		9.6929978859
595PhosphorylationMKLPGDHSYVSQPLV
CCCCCCCCCCCCCEE		31.7830266825
596PhosphorylationKLPGDHSYVSQPLVV
CCCCCCCCCCCCEEE		10.7425884760
598PhosphorylationPGDHSYVSQPLVVPA
CCCCCCCCCCEEEEH		20.1830266825
639PhosphorylationQIQPQPLSSQAISQQ
HCCCCCCCCHHHHHH		27.3828348404
640PhosphorylationIQPQPLSSQAISQQH
CCCCCCCCHHHHHHH		31.1728348404
644PhosphorylationPLSSQAISQQHLQDA
CCCCHHHHHHHHHHC		27.1428348404
668PhosphorylationASMSESLSIPASLND
CCCCCCCCCCHHCCH		35.4922210691
672PhosphorylationESLSIPASLNDAALA
CCCCCCHHCCHHHHH		23.5022210691
711PhosphorylationHPRAWFVSLDGRSNA
CCCEEEEEECCCCCC		15.9830576142
716PhosphorylationFVSLDGRSNAHVRHS
EEEECCCCCCEEEEE		43.8527251275
723PhosphorylationSNAHVRHSYIDLQRA
CCCEEEEEEEEHHHC		17.1428348404
724PhosphorylationNAHVRHSYIDLQRAG
CCEEEEEEEEHHHCC		7.7324927040
735PhosphorylationQRAGRNGSNDASLDS
HHCCCCCCCCCCCCC		34.7828348404
742PhosphorylationSNDASLDSGVDMNEP
CCCCCCCCCCCCCCC		46.1128985074
799PhosphorylationDDVEQSGSECGTTVC
CCHHHCCCCCCCEEE		34.6522210691
807PhosphorylationECGTTVCTPEDSALR
CCCCEEECCCHHHHH		25.9422210691
811PhosphorylationTVCTPEDSALRCLLE
EEECCCHHHHHHHHH		27.7822210691
820PhosphorylationLRCLLEGSSRRSGGQ
HHHHHHCCCCCCCCC		15.9929449344
821PhosphorylationRCLLEGSSRRSGGQL
HHHHHCCCCCCCCCC		42.4429449344
824PhosphorylationLEGSSRRSGGQLPSL
HHCCCCCCCCCCCCC		46.2830266825
830PhosphorylationRSGGQLPSLQEETTR
CCCCCCCCCCCHHCC		51.8023403867
835PhosphorylationLPSLQEETTRRTADA
CCCCCCHHCCCCCCC		25.5023312004
836PhosphorylationPSLQEETTRRTADAP
CCCCCHHCCCCCCCC		22.7923312004
839PhosphorylationQEETTRRTADAPSEP
CCHHCCCCCCCCCCC		26.1223403867
844PhosphorylationRRTADAPSEPAASPH
CCCCCCCCCCCCCHH		58.9123927012
849PhosphorylationAPSEPAASPHQRRSA
CCCCCCCCHHHCCCC		25.6430266825
855PhosphorylationASPHQRRSAHEEEED
CCHHHCCCCCCCCCC		35.8521955146
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of F1711_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of F1711_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of F1711_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of F1711_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of F1711_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-159, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography.";
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.;
Proteomics 8:1346-1361(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-855, AND MASSSPECTROMETRY.

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