STX6_HUMAN - dbPTM
STX6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STX6_HUMAN
UniProt AC O43752
Protein Name Syntaxin-6
Gene Name STX6
Organism Homo sapiens (Human).
Sequence Length 255
Subcellular Localization Golgi apparatus membrane
Single-pass type IV membrane protein .
Protein Description Involved in intracellular vesicle trafficking..
Protein Sequence MSMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWDLEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLILFLVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSMEDPFFV
------CCCCCCEEE		30.7728355574
2Acetylation------MSMEDPFFV
------CCCCCCEEE		30.7720068231
17UbiquitinationVKGEVQKAVNTAQGL
EHHHHHHHHHHHHHH		5.2329967540
38UbiquitinationLLQDPSTATREEIDW
HHCCCCCCCHHHCCC		14.70-
38UbiquitinationLLQDPSTATREEIDW
HHCCCCCCCHHHCCC		14.7023000965
77UbiquitinationIVEANPRKFNLDATE
HHCCCCCCCCCCCHH		39.6022817900
77UbiquitinationIVEANPRKFNLDATE
HHCCCCCCCCCCCHH		39.6021890473
83PhosphorylationRKFNLDATELSIRKA
CCCCCCCHHHHHHHH		36.8121406692
83UbiquitinationRKFNLDATELSIRKA
CCCCCCCHHHHHHHH		36.81-
83UbiquitinationRKFNLDATELSIRKA
CCCCCCCHHHHHHHH		36.8121963094
86PhosphorylationNLDATELSIRKAFIT
CCCCHHHHHHHHHHH		17.7025159151
89UbiquitinationATELSIRKAFITSTR
CHHHHHHHHHHHHHH		46.0824816145
103UbiquitinationRQVVRDMKDQMSTSS
HHHHHHHHHHCCHHH		49.4424816145
107PhosphorylationRDMKDQMSTSSVQAL
HHHHHHCCHHHHHHH		21.36-
109PhosphorylationMKDQMSTSSVQALAE
HHHHCCHHHHHHHHH		22.6228555341
118UbiquitinationVQALAERKNRQALLG
HHHHHHHHCHHHHHC		48.2429967540
119UbiquitinationQALAERKNRQALLGD
HHHHHHHCHHHHHCC		47.7433845483
127PhosphorylationRQALLGDSGSQNWST
HHHHHCCCCCCCCCC		38.2523401153
129PhosphorylationALLGDSGSQNWSTGT
HHHCCCCCCCCCCCC		25.0517525332
133PhosphorylationDSGSQNWSTGTTDKY
CCCCCCCCCCCCCCH		25.2225159151
134PhosphorylationSGSQNWSTGTTDKYG
CCCCCCCCCCCCCHH		30.1123663014
136PhosphorylationSQNWSTGTTDKYGRL
CCCCCCCCCCCHHHH		31.7323663014
137PhosphorylationQNWSTGTTDKYGRLD
CCCCCCCCCCHHHHH		31.6623663014
139UbiquitinationWSTGTTDKYGRLDRE
CCCCCCCCHHHHHHH		47.7321890473
139UbiquitinationWSTGTTDKYGRLDRE
CCCCCCCCHHHHHHH		47.7323000965
140PhosphorylationSTGTTDKYGRLDREL
CCCCCCCHHHHHHHH		15.4129978859
152PhosphorylationRELQRANSHFIEEQQ
HHHHHHHHHHHHHHH		20.8428102081
184UbiquitinationSGSIGVLKNMSQRIG
HHHHHHHHHHHHHHC		48.4721963094
205PhosphorylationAVMLEDFSHELESTQ
HHHHHHHHHHHHHHH		28.5127690223
210PhosphorylationDFSHELESTQSRLDN
HHHHHHHHHHHHHHH		44.3527690223
211PhosphorylationFSHELESTQSRLDNV
HHHHHHHHHHHHHHH		22.6127690223
213PhosphorylationHELESTQSRLDNVMK
HHHHHHHHHHHHHHH		34.5927690223
220UbiquitinationSRLDNVMKKLAKVSH
HHHHHHHHHHHHHHC		40.1133845483
229PhosphorylationLAKVSHMTSDRRQWC
HHHHHCCCCCHHHHH		23.27-
230PhosphorylationAKVSHMTSDRRQWCA
HHHHCCCCCHHHHHH		22.88-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STX6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STX6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STX6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VAMP3_HUMANVAMP3physical
11839770
VAMP4_HUMANVAMP4physical
11839770
VAMP8_HUMANVAMP8physical
11839770
VPS53_HUMANVPS53physical
20685960
VPS52_HUMANVPS52physical
20685960
VPS51_HUMANVPS51physical
20685960
VPS54_HUMANVPS54physical
20685960
MARH2_HUMANMARCH2physical
23818989
SNAB_HUMANNAPBphysical
25416956
VPS45_HUMANVPS45physical
26186194
SNAA_HUMANNAPAphysical
26186194
STX4_HUMANSTX4physical
26186194
STX18_HUMANSTX18physical
26186194
GOSR1_HUMANGOSR1physical
26186194
TF3C2_HUMANGTF3C2physical
26186194
CUX1_HUMANCUX1physical
26186194
CASP_HUMANCUX1physical
26186194
STX5_HUMANSTX5physical
26186194
TF3C1_HUMANGTF3C1physical
26186194
SNP23_HUMANSNAP23physical
26186194
B3GA3_HUMANB3GAT3physical
26186194
STX7_HUMANSTX7physical
26186194
STX12_HUMANSTX12physical
26186194
SEC20_HUMANBNIP1physical
26186194
SCFD1_HUMANSCFD1physical
26186194
CGT_HUMANUGT8physical
26186194
SNP29_HUMANSNAP29physical
26186194
STX8_HUMANSTX8physical
26186194
GOSR2_HUMANGOSR2physical
26186194
SNAG_HUMANNAPGphysical
26186194
TF3C3_HUMANGTF3C3physical
26186194
VTI1A_HUMANVTI1Aphysical
26186194
NBAS_HUMANNBASphysical
26186194
VAMP3_HUMANVAMP3physical
26186194
STX3_HUMANSTX3physical
26186194
VAMP8_HUMANVAMP8physical
26186194
STX10_HUMANSTX10physical
26186194
STXB5_HUMANSTXBP5physical
26186194
SNAB_HUMANNAPBphysical
21516116
STX4_HUMANSTX4physical
21516116
STX7_HUMANSTX7physical
28514442
STX12_HUMANSTX12physical
28514442
STX3_HUMANSTX3physical
28514442
VTI1A_HUMANVTI1Aphysical
28514442
VAMP8_HUMANVAMP8physical
28514442
GOSR2_HUMANGOSR2physical
28514442
STX18_HUMANSTX18physical
28514442
STXB5_HUMANSTXBP5physical
28514442
GOSR1_HUMANGOSR1physical
28514442
CUX1_HUMANCUX1physical
28514442
CASP_HUMANCUX1physical
28514442
STX5_HUMANSTX5physical
28514442
SNAG_HUMANNAPGphysical
28514442
B3GA3_HUMANB3GAT3physical
28514442
STX4_HUMANSTX4physical
28514442
STX8_HUMANSTX8physical
28514442
VAMP3_HUMANVAMP3physical
28514442
TF3C2_HUMANGTF3C2physical
28514442
TF3C1_HUMANGTF3C1physical
28514442
NBAS_HUMANNBASphysical
28514442
TF3C3_HUMANGTF3C3physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STX6_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND MASSSPECTROMETRY.
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory