B3GA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B3GA3_HUMAN
• UniProt AC: O94766
• Protein Name: Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
• Gene Name: B3GAT3
• Organism: Homo sapiens (Human).
• Sequence Length: 335
• Subcellular Localization: Golgi apparatus membrane ; Single-pass type II membrane protein . Golgi apparatus, cis-Golgi network .
• Protein Description: Glycosaminoglycans biosynthesis. [PubMed: 25893793 Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation]
• Protein Sequence: MKLKLKNVFLAYFLVSIAGLLYALVQLGQPCDCLPPLRAAAEQLRQKDLRISQLQAELRRPPPAPAQPPEPEALPTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPLVSGLLAASGLLFTHLVVLTPKAQRLREGEPGWVHPRGVEQRNKALDWLRGRGGAVGGEKDPPPPGTQGVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGRVVGFHTAWEPSRPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLLSHLVDPKDLEPRAANCTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	LKNVFLAYFLVSIAG HHHHHHHHHHHHHHH	10.29	22817900
90	Ubiquitination	TYARLVQKAELVRLS HHHHHHHHHHHHHHH	36.03	-
90	Ubiquitination	TYARLVQKAELVRLS HHHHHHHHHHHHHHH	36.03	-
300	N-linked_Glycosylation	DLEPRAANCTRVLVW HCCHHHHCCCEEEEE	27.06	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B3GA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B3GA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B3GA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B3GA3_HUMAN	B3GAT3	physical	10842173
SC22B_HUMAN	SEC22B	physical	21988832
K1468_HUMAN	KIAA1468	physical	26186194
JPH1_HUMAN	JPH1	physical	26186194
GOLI4_HUMAN	GOLIM4	physical	26186194
NLGN2_HUMAN	NLGN2	physical	26186194
COL12_HUMAN	COLEC12	physical	26186194
MAN1_HUMAN	LEMD3	physical	26186194
CKAP4_HUMAN	CKAP4	physical	26186194
DAAF5_HUMAN	DNAAF5	physical	26186194
HEAT3_HUMAN	HEATR3	physical	26186194
PBIP1_HUMAN	PBXIP1	physical	26186194
HMDH_HUMAN	HMGCR	physical	26186194
SEC62_HUMAN	SEC62	physical	26186194
HAUS7_HUMAN	HAUS7	physical	26186194
WDR13_HUMAN	WDR13	physical	26186194
NOP9_HUMAN	NOP9	physical	26186194
K1468_HUMAN	KIAA1468	physical	28514442
WDR13_HUMAN	WDR13	physical	28514442
GOLI4_HUMAN	GOLIM4	physical	28514442
NLGN2_HUMAN	NLGN2	physical	28514442
COL12_HUMAN	COLEC12	physical	28514442
HAUS7_HUMAN	HAUS7	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
DAAF5_HUMAN	DNAAF5	physical	28514442
PBIP1_HUMAN	PBXIP1	physical	28514442
NLGN1_HUMAN	NLGN1	physical	28514442
HEAT3_HUMAN	HEATR3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• 245600: Multiple joint dislocations short stature craniofacial dysmorphism and congenital heart defects (JDSSDHD)
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.