NLGN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NLGN2_HUMAN
• UniProt AC: Q8NFZ4
• Protein Name: Neuroligin-2
• Gene Name: NLGN2
• Organism: Homo sapiens (Human).
• Sequence Length: 835
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Detected at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons.
• Protein Description: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity)..
• Protein Sequence: MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	GPGLGLGSLGEERFP CCCCCCCCCCCCCCC	37.94	21815630
98	N-linked_Glycosylation	ASWPGVRNATTLPPA CCCCCCCCCCCCCCC	38.95	UniProtKB CARBOHYD
136	N-linked_Glycosylation	AAATYVQNQSEDCLY HHHHHHHCCCCCCEE	36.98	UniProtKB CARBOHYD
163	O-linked_Glycosylation	TKKRDEATLNPPDTD CCCCCCCCCCCCCCC	25.64	OGP
418	Phosphorylation	SNFVDNLYGYPEGKD HHHHHHHHCCCCCHH	22.37	-
522	N-linked_Glycosylation	ATDLFPCNFSKNDVM CCCCCCCCCCCCHHH	44.45	UniProtKB CARBOHYD
561	Ubiquitination	DTKFIHTKPNRFEEV CCCEECCCCCCHHHH	26.57	-
648	O-linked_Glycosylation	RRPPPPATLPPEPEP CCCCCCCCCCCCCCC	45.64	OGP
713	Phosphorylation	ELRCRRLSPPGGSGS HHEEEECCCCCCCCC	27.51	26657352
718	Phosphorylation	RLSPPGGSGSGVPGG ECCCCCCCCCCCCCC	35.38	20886841
720	Phosphorylation	SPPGGSGSGVPGGGP CCCCCCCCCCCCCCC	38.01	30266825
748	Ubiquitination	ELVSLQLKRGGGVGA HHEEEEECCCCCCCC	35.72	33845483
769	Phosphorylation	RPACPPDYTLALRRA CCCCCCCCEEEECCC	14.93	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NLGN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NLGN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NLGN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG4_HUMAN	DLG4	physical	9278515
DLG3_HUMAN	DLG3	physical	9278515
DLG2_HUMAN	DLG2	physical	9278515

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.