NLGN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NLGN1_HUMAN
• UniProt AC: Q8N2Q7
• Protein Name: Neuroligin-1
• Gene Name: NLGN1
• Organism: Homo sapiens (Human).
• Sequence Length: 840
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. D
• Protein Description: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep..
• Protein Sequence: MALPRCTWPNYVWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKRDEATLNPPDTDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITFRPTRKNSVPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTFTGGQNNTLPHPHPHPHSHSTTRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	PRCTWPNYVWRAVMA CCCCCCHHHHHHHHH	9.41	27067055
102	Phosphorylation	FQPPEPPSPWSDIRN CCCCCCCCCHHHHCC	50.11	25850435
105	Phosphorylation	PEPPSPWSDIRNATQ CCCCCCHHHHCCCCC	26.92	25850435
109	N-linked_Glycosylation	SPWSDIRNATQFAPV CCHHHHCCCCCCCCC	47.90	UniProtKB CARBOHYD
300	N-linked_Glycosylation	SEGNRWSNSTKGLFQ CCCCCCCCCHHHHHH	46.90	UniProtKB CARBOHYD
313	Phosphorylation	FQRAIAQSGTALSSW HHHHHHHHCCCHHHC	29.14	30576142
315	Phosphorylation	RAIAQSGTALSSWAV HHHHHHCCCHHHCHH	29.67	30576142
323	N-linked_Glycosylation	ALSSWAVSFQPAKYA CHHHCHHHCCHHHHH	15.49	-
329	Phosphorylation	VSFQPAKYARMLATK HHCCHHHHHHHHHHH	11.10	30576142
340	N-linked_Glycosylation	LATKVGCNVSDTVEL HHHHCCCCHHHHHHH	30.33	UniProtKB CARBOHYD
363	N-linked_Glycosylation	YKELVDQDIQPARYH HHHHCCCCCCCCCEE	36.71	-
440	Phosphorylation	SNFVDNLYGYPEGKD HHHHHHHHCCCCCHH	22.37	-
544	N-linked_Glycosylation	PTELFPCNFSKNDVM CCCCCCCCCCCCHHH	44.45	UniProtKB CARBOHYD
567	N-linked_Glycosylation	WTNFAKTGDPNQPVP HHHHHCCCCCCCCCC	47.90	-
660	O-linked_Glycosylation	FRPTRKNSVPVTSAF ECCCCCCCCCCCCCC	30.73	OGP
664	O-linked_Glycosylation	RKNSVPVTSAFPTAK CCCCCCCCCCCCCCC	14.31	OGP
665	O-linked_Glycosylation	KNSVPVTSAFPTAKQ CCCCCCCCCCCCCCC	28.31	OGP
669	Phosphorylation	PVTSAFPTAKQDDPK CCCCCCCCCCCCCCC	39.78	20363803
669	O-linked_Glycosylation	PVTSAFPTAKQDDPK CCCCCCCCCCCCCCC	39.78	OGP
680	O-linked_Glycosylation	DDPKQQPSPFSVDQR CCCCCCCCCCCCCCC	33.95	UniProtKB CARBOHYD
683	O-linked_Glycosylation	KQQPSPFSVDQRDYS CCCCCCCCCCCCCCC	28.33	UniProtKB CARBOHYD
689	Phosphorylation	FSVDQRDYSTELSVT CCCCCCCCCCCHHHH	21.49	25072903
690	Phosphorylation	SVDQRDYSTELSVTI CCCCCCCCCCHHHHH	21.50	25072903
691	Phosphorylation	VDQRDYSTELSVTIA CCCCCCCCCHHHHHH	34.41	25072903
694	Phosphorylation	RDYSTELSVTIAVGA CCCCCCHHHHHHHHH	15.81	25072903
696	Phosphorylation	YSTELSVTIAVGASL CCCCHHHHHHHHHHH	10.39	25072903
702	Phosphorylation	VTIAVGASLLFLNIL HHHHHHHHHHHHHHH	21.48	25072903
703	O-linked_Glycosylation	TIAVGASLLFLNILA HHHHHHHHHHHHHHH	3.77	-
706	O-linked_Glycosylation	VGASLLFLNILAFAA HHHHHHHHHHHHHHH	3.82	-
715	Phosphorylation	ILAFAALYYKKDKRR HHHHHHHHHHHHHHH	14.44	25072903
716	Phosphorylation	LAFAALYYKKDKRRH HHHHHHHHHHHHHHH	16.65	25072903
730	Phosphorylation	HDVHRRCSPQRTTTN HCCHHHCCCCCCCCC	23.43	-
734	Phosphorylation	RRCSPQRTTTNDLTH HHCCCCCCCCCCCCH	32.50	30619164
735	Phosphorylation	RCSPQRTTTNDLTHA HCCCCCCCCCCCCHH	26.28	30619164
736	Phosphorylation	CSPQRTTTNDLTHAQ CCCCCCCCCCCCHHH	26.56	30619164
749	Phosphorylation	AQEEEIMSLQMKHTD HHHHHHHHHHHHCCC	22.55	30576142
763	Phosphorylation	DLDHECESIHPHEVV CCCCCCCCCCCCCEE	37.54	29255136
779	Phosphorylation	RTACPPDYTLAMRRS EECCCCCCEEEECCC	14.93	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NLGN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NLGN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NLGN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG4_HUMAN	DLG4	physical	9278515
DLG3_HUMAN	DLG3	physical	9278515
DLG2_HUMAN	DLG2	physical	9278515

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.