| UniProt ID | GOSR2_HUMAN | |
|---|---|---|
| UniProt AC | O14653 | |
| Protein Name | Golgi SNAP receptor complex member 2 | |
| Gene Name | GOSR2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 212 | |
| Subcellular Localization |
Golgi apparatus, cis-Golgi network membrane Single-pass type IV membrane protein . Golgi apparatus membrane . Endoplasmic reticulum membrane . Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. |
|
| Protein Description | Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.. | |
| Protein Sequence | MDPLFQQTHKQVHEIQSCMGRLETADKQSVHIVENEIQASIDQIFSRLERLEILSSKEPPNKRQNARLRVDQLKYDVQHLQTALRNFQHRRHAREQQERQREELLSRTFTTNDSDTTIPMDESLQFNSSLQKVHNGMDDLILDGHNILDGLRTQRLTLKGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIGGMLLTCVVMFLVVQYLT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDPLFQQT -------CCHHHHHH | 12.35 | - | |
| 27 | Ubiquitination | GRLETADKQSVHIVE CHHCCCCCCCEEHHH | 41.85 | - | |
| 57 | Acetylation | RLEILSSKEPPNKRQ HHHHHHCCCCCCHHH | 71.51 | 8082823 | |
| 57 | Ubiquitination | RLEILSSKEPPNKRQ HHHHHHCCCCCCHHH | 71.51 | - | |
| 62 | Acetylation | SSKEPPNKRQNARLR HCCCCCCHHHCHHHH | 62.22 | 8082833 | |
| 74 | 2-Hydroxyisobutyrylation | RLRVDQLKYDVQHLQ HHHHHHHHHHHHHHH | 33.50 | - | |
| 75 | Phosphorylation | LRVDQLKYDVQHLQT HHHHHHHHHHHHHHH | 29.91 | - | |
| 106 | Phosphorylation | RQREELLSRTFTTND HHHHHHHHCCEECCC | 41.73 | 24719451 | |
| 108 | Phosphorylation | REELLSRTFTTNDSD HHHHHHCCEECCCCC | 23.20 | 30266825 | |
| 110 | Phosphorylation | ELLSRTFTTNDSDTT HHHHCCEECCCCCCC | 24.87 | 30266825 | |
| 111 | Phosphorylation | LLSRTFTTNDSDTTI HHHCCEECCCCCCCE | 32.60 | 30266825 | |
| 114 | Phosphorylation | RTFTTNDSDTTIPMD CCEECCCCCCCEECC | 38.64 | 30266825 | |
| 116 | Phosphorylation | FTTNDSDTTIPMDES EECCCCCCCEECCHH | 30.49 | 30266825 | |
| 117 | Phosphorylation | TTNDSDTTIPMDESL ECCCCCCCEECCHHH | 28.24 | 30266825 | |
| 123 | Phosphorylation | TTIPMDESLQFNSSL CCEECCHHHCCCHHH | 24.17 | 30266825 | |
| 159 | Ubiquitination | RTQRLTLKGTQKKIL HHHCCCCCCHHHHHH | 55.46 | - | |
| 175 | Phosphorylation | IANMLGLSNTVMRLI HHHHHCCCHHHHHHH | 28.76 | - | |
| 177 | Phosphorylation | NMLGLSNTVMRLIEK HHHCCCHHHHHHHHH | 16.59 | - | |
| 191 | Phosphorylation | KRAFQDKYFMIGGML HHHCCCCCHHHHHHH | 13.48 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GOSR2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GOSR2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GOSR2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| STX5_HUMAN | STX5 | physical | 9647643 | |
| A4_HUMAN | APP | physical | 21832049 | |
| STX6_HUMAN | STX6 | physical | 25416956 | |
| KASH5_HUMAN | CCDC155 | physical | 25416956 | |
| PHB_HUMAN | PHB | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614018 | Epilepsy, progressive myoclonic 6 (EPM6) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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