MPP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPP3_HUMAN
• UniProt AC: Q13368
• Protein Name: MAGUK p55 subfamily member 3
• Gene Name: MPP3
• Organism: Homo sapiens (Human).
• Sequence Length: 585
• Protein Sequence: MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVSWVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
136	Ubiquitination	DFDEESVKIVRLVKN CCCHHHHHHEEEECC	44.77	-
150	Phosphorylation	NKEPLGATIRRDEHS CCCCCCCEEECCCCC	17.14	19276368
174	Phosphorylation	RGGAADRSGLVHVGD CCCCCCCCCCCCCCH	36.71	-
200	Phosphorylation	HKRPDEISQILAQSQ ECCHHHHHHHHHHCC	14.77	30576142
209	Phosphorylation	ILAQSQGSITLKIIP HHHHCCCCEEEEEEE	12.55	30576142
211	Phosphorylation	AQSQGSITLKIIPAT HHCCCCEEEEEEECC	24.56	30576142
288	Phosphorylation	LRAGLIPSKGFQERR CCCCCCCCCCHHHHH	38.12	30266825
304	Phosphorylation	SYRRAAGTLPSPQSL HHHHHCCCCCCCHHH	30.67	24117733
307	Phosphorylation	RAAGTLPSPQSLRKP HHCCCCCCCHHHCCC	38.39	24117733
310	Phosphorylation	GTLPSPQSLRKPPYD CCCCCCHHHCCCCCC	33.26	24117733
313	Acetylation	PSPQSLRKPPYDQPC CCCHHHCCCCCCCCC	56.49	18586609
316	Phosphorylation	QSLRKPPYDQPCDKE HHHCCCCCCCCCCCC	35.42	21394647
322	Acetylation	PYDQPCDKETCDCEG CCCCCCCCCCCCCCH	62.73	18586617
361	Phosphorylation	SQEGKMSSGAESPEL CCCCCCCCCCCCCCC	38.22	27732954
365	Phosphorylation	KMSSGAESPELLTYE CCCCCCCCCCCCCHH	24.12	27732954
371	Phosphorylation	ESPELLTYEEVARYQ CCCCCCCHHHHHHHC	15.29	26437602
537	Phosphorylation	QQQEMAASAAFIDRH HHHHHHHHHHHHHHH	15.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOA1_HUMAN	NOA1	physical	16169070
GBG7_HUMAN	GNG7	physical	16169070
MDHC_HUMAN	MDH1	physical	16169070
CC137_HUMAN	CCDC137	physical	16169070
PLK2_HUMAN	PLK2	physical	16169070
RS2_HUMAN	RPS2	physical	16169070
HAP1_HUMAN	HAP1	physical	16169070
MCM2_HUMAN	MCM2	physical	16169070
A4_HUMAN	APP	physical	21832049
ZPR1_HUMAN	ZPR1	physical	21988832
RRAGC_HUMAN	RRAGC	physical	21988832
TIRAP_HUMAN	TIRAP	physical	21988832
CCGL_HUMAN	TMEM37	physical	21988832
TRAF2_HUMAN	TRAF2	physical	25416956
LIN7A_HUMAN	LIN7A	physical	25416956
SNTG2_HUMAN	SNTG2	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.