PSA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSA_HUMAN
• UniProt AC: P55786
• Protein Name: Puromycin-sensitive aminopeptidase
• Gene Name: NPEPPS
• Organism: Homo sapiens (Human).
• Sequence Length: 919
• Subcellular Localization: Cytoplasm, cytosol . Nucleus .
• Protein Description: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain..
• Protein Sequence: MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDAESIHQYLLQRKASPPTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Ubiquitination	LGPPPPPLLLLVFSR HCCCCCCEEEEEECC	6.93	-
30	Phosphorylation	PLLLLVFSRSSRRRL CEEEEEECCCHHHHH	24.63	-
39	Phosphorylation	SSRRRLHSLGLAAMP CHHHHHHHCCCCCCC	28.82	28857561
48	Acetylation	GLAAMPEKRPFERLP CCCCCCCCCCCCCCC	60.54	19608861
59	Phosphorylation	ERLPADVSPINYSLC CCCCCCCCCCCEEEE	22.17	24719451
79	Ubiquitination	LDFTFEGKLEAAAQV CCEEECCHHHHHHHH	35.64	-
136	Phosphorylation	VTLSFPSTLQTGTGT EEEECCCEEECCCCE	24.11	26437602
155	Ubiquitination	FVGELNDKMKGFYRS EEEECCHHHCCEECC	41.25	21890473
155	2-Hydroxyisobutyrylation	FVGELNDKMKGFYRS EEEECCHHHCCEECC	41.25	-
155	Ubiquitination	FVGELNDKMKGFYRS EEEECCHHHCCEECC	41.25	21890473
157	Ubiquitination	GELNDKMKGFYRSKY EECCHHHCCEECCCE	52.16	-
162	Phosphorylation	KMKGFYRSKYTTPSG HHCCEECCCEECCCC	20.73	28152594
163	2-Hydroxyisobutyrylation	MKGFYRSKYTTPSGE HCCEECCCEECCCCC	37.30	-
163	Acetylation	MKGFYRSKYTTPSGE HCCEECCCEECCCCC	37.30	25953088
163	Ubiquitination	MKGFYRSKYTTPSGE HCCEECCCEECCCCC	37.30	-
164	Phosphorylation	KGFYRSKYTTPSGEV CCEECCCEECCCCCE	19.66	28152594
165	Phosphorylation	GFYRSKYTTPSGEVR CEECCCEECCCCCEE	35.65	28152594
166	Phosphorylation	FYRSKYTTPSGEVRY EECCCEECCCCCEEE	16.62	28152594
168	Phosphorylation	RSKYTTPSGEVRYAA CCCEECCCCCEEEEE	45.56	22985185
173	Phosphorylation	TPSGEVRYAAVTQFE CCCCCEEEEEEEEEE	12.23	24927040
177	Phosphorylation	EVRYAAVTQFEATDA CEEEEEEEEEECCCH	23.86	28152594
194	Ubiquitination	AFPCWDEPAIKATFD HCCCCCCCCCEEEEE	36.49	-
199	Phosphorylation	DEPAIKATFDISLVV CCCCCEEEEEEEEEE	19.48	20068231
203	O-linked_Glycosylation	IKATFDISLVVPKDR CEEEEEEEEEECCCC	19.56	29351928
203	Phosphorylation	IKATFDISLVVPKDR CEEEEEEEEEECCCC	19.56	20068231
208	Ubiquitination	DISLVVPKDRVALSN EEEEEECCCCEEECC	46.70	21890473
208	Ubiquitination	DISLVVPKDRVALSN EEEEEECCCCEEECC	46.70	21890473
214	Phosphorylation	PKDRVALSNMNVIDR CCCCEEECCCCCCCC	25.05	21712546
216	Sulfoxidation	DRVALSNMNVIDRKP CCEEECCCCCCCCCC	3.68	30846556
222	Ubiquitination	NMNVIDRKPYPDDEN CCCCCCCCCCCCCCC	45.19	21890473
224	Phosphorylation	NVIDRKPYPDDENLV CCCCCCCCCCCCCCE	23.48	28152594
234	Ubiquitination	DENLVEVKFARTPVM CCCCEEEEECCCCCC	21.57	21890473
234	Acetylation	DENLVEVKFARTPVM CCCCEEEEECCCCCC	21.57	26051181
234	Ubiquitination	DENLVEVKFARTPVM CCCCEEEEECCCCCC	21.57	21890473
269	Phosphorylation	DGVCVRVYTPVGKAE CCEEEEEEECCCCHH	8.51	28152594
270	Phosphorylation	GVCVRVYTPVGKAEQ CEEEEEEECCCCHHC	14.51	28152594
274	2-Hydroxyisobutyrylation	RVYTPVGKAEQGKFA EEEECCCCHHCCCHH	49.32	-
274	Ubiquitination	RVYTPVGKAEQGKFA EEEECCCCHHCCCHH	49.32	21890473
279	Ubiquitination	VGKAEQGKFALEVAA CCCHHCCCHHHHHHH	27.45	-
287	Ubiquitination	FALEVAAKTLPFYKD HHHHHHHHHCCCCHH	40.64	21890473
287	Ubiquitination	FALEVAAKTLPFYKD HHHHHHHHHCCCCHH	40.64	21890473
288	Phosphorylation	ALEVAAKTLPFYKDY HHHHHHHHCCCCHHH	34.63	26074081
292	Phosphorylation	AAKTLPFYKDYFNVP HHHHCCCCHHHHCCC	10.87	26074081
293	Ubiquitination	AKTLPFYKDYFNVPY HHHCCCCHHHHCCCC	46.46	21890473
293	Ubiquitination	AKTLPFYKDYFNVPY HHHCCCCHHHHCCCC	46.46	21890473
295	Phosphorylation	TLPFYKDYFNVPYPL HCCCCHHHHCCCCCC	7.90	26074081
300	Phosphorylation	KDYFNVPYPLPKIDL HHHHCCCCCCCCCCE	17.08	26074081
329	Phosphorylation	GLVTYRETALLIDPK CCEEEEEEEEEECCC	17.38	-
336	Acetylation	TALLIDPKNSCSSSR EEEEECCCCCCCCCH	58.71	26051181
336	Succinylation	TALLIDPKNSCSSSR EEEEECCCCCCCCCH	58.71	23954790
440	Ubiquitination	FDAISYSKGASVIRM HHHHHHHCCHHHHHH	50.71	21890473
455	Ubiquitination	LHDYIGDKDFKKGMN HHHHHCCCCHHHHHH	60.91	21890473
455	2-Hydroxyisobutyrylation	LHDYIGDKDFKKGMN HHHHHCCCCHHHHHH	60.91	-
455	Acetylation	LHDYIGDKDFKKGMN HHHHHCCCCHHHHHH	60.91	23236377
455	Ubiquitination	LHDYIGDKDFKKGMN HHHHHCCCCHHHHHH	60.91	21890473
458	2-Hydroxyisobutyrylation	YIGDKDFKKGMNMYL HHCCCCHHHHHHHHH	59.56	-
459	Acetylation	IGDKDFKKGMNMYLT HCCCCHHHHHHHHHH	64.48	155887
459	Ubiquitination	IGDKDFKKGMNMYLT HCCCCHHHHHHHHHH	64.48	-
464	Nitrated tyrosine	FKKGMNMYLTKFQQK HHHHHHHHHHHHHHC	13.25	-
464	Nitration	FKKGMNMYLTKFQQK HHHHHHHHHHHHHHC	13.25	-
464	Phosphorylation	FKKGMNMYLTKFQQK HHHHHHHHHHHHHHC	13.25	-
466	Phosphorylation	KGMNMYLTKFQQKNA HHHHHHHHHHHHCCC	16.60	-
467	Ubiquitination	GMNMYLTKFQQKNAA HHHHHHHHHHHCCCC	38.28	21890473
467	Ubiquitination	GMNMYLTKFQQKNAA HHHHHHHHHHHCCCC	38.28	21890473
478	Ubiquitination	KNAATEDLWESLENA CCCCCHHHHHHHHHC	4.44	-
488	Ubiquitination	SLENASGKPIAAVMN HHHHCCCCCCHHHHH	30.65	-
501	Sulfoxidation	MNTWTKQMGFPLIYV HHHHHHHHCCCEEEE	6.78	30846556
558	Ubiquitination	DPNQAKLKILMDKPE CCCHHHEEEECCCHH	32.84	-
561	Sulfoxidation	QAKLKILMDKPEMNV HHHEEEECCCHHHEE	7.68	30846556
563	Ubiquitination	KLKILMDKPEMNVVL HEEEECCCHHHEEEE	28.98	-
566	Sulfoxidation	ILMDKPEMNVVLKNV EECCCHHHEEEEECC	6.64	30846556
574	Ubiquitination	NVVLKNVKPDQWVKL EEEEECCCHHHEEEE	52.88	-
593	Phosphorylation	VGFYRTQYSSAMLES CCCCHHHHCHHHHHH	12.18	24076635
594	Phosphorylation	GFYRTQYSSAMLESL CCCHHHHCHHHHHHH	11.21	21712546
595	Phosphorylation	FYRTQYSSAMLESLL CCHHHHCHHHHHHHC	16.86	20068231
609	Phosphorylation	LPGIRDLSLPPVDRL CCCCCCCCCCCCCCC	43.02	20068231
615	Methylation	LSLPPVDRLGLQNDL CCCCCCCCCCCCCHH	30.78	115485475
624	Phosphorylation	GLQNDLFSLARAGII CCCCHHHHHHHHCCC	28.54	22964224
632	Phosphorylation	LARAGIISTVEVLKV HHHHCCCCHHHHHHH	25.20	20068231
633	Phosphorylation	ARAGIISTVEVLKVM HHHCCCCHHHHHHHH	15.41	20068231
656	Ubiquitination	YTVWSDLSCNLGILS CEEEHHHHCHHHHHH	13.12	-
684	Phosphorylation	EFVKDVFSPIGERLG HHHHHHHCHHHHHHC	18.56	21815630
712	2-Hydroxyisobutyrylation	LRGLVLGKLGKAGHK HHHHHHHHHHHHCCH	50.32	-
712	Acetylation	LRGLVLGKLGKAGHK HHHHHHHHHHHHCCH	50.32	25953088
712	Malonylation	LRGLVLGKLGKAGHK HHHHHHHHHHHHCCH	50.32	26320211
719	Ubiquitination	KLGKAGHKATLEEAR HHHHHCCHHHHHHHH	41.99	-
730	Ubiquitination	EEARRRFKDHVEGKQ HHHHHHHHHHCCCCE	45.15	-
736	2-Hydroxyisobutyrylation	FKDHVEGKQILSADL HHHHCCCCEEECCCC	22.21	-
736	Acetylation	FKDHVEGKQILSADL HHHHCCCCEEECCCC	22.21	26822725
736	Ubiquitination	FKDHVEGKQILSADL HHHHCCCCEEECCCC	22.21	-
740	Phosphorylation	VEGKQILSADLRSPV CCCCEEECCCCCCCE	22.74	22673903
745	Phosphorylation	ILSADLRSPVYLTVL EECCCCCCCEEEEEE	26.47	30266825
748	Phosphorylation	ADLRSPVYLTVLKHG CCCCCCEEEEEEECC	10.47	30266825
749	Ubiquitination	DLRSPVYLTVLKHGD CCCCCEEEEEEECCC	2.45	-
750	Phosphorylation	LRSPVYLTVLKHGDG CCCCEEEEEEECCCC	13.20	30266825
752	Acetylation	SPVYLTVLKHGDGTT CCEEEEEEECCCCCC	2.60	-
752	Ubiquitination	SPVYLTVLKHGDGTT CCEEEEEEECCCCCC	2.60	-
763	Sulfoxidation	DGTTLDIMLKLHKQA CCCCHHHHHHHHHHC	2.42	30846556
772	Sulfoxidation	KLHKQADMQEEKNRI HHHHHCCCHHHHHHH	6.39	30846556
776	Ubiquitination	QADMQEEKNRIERVL HCCCHHHHHHHHHHH	51.26	-
783	Ubiquitination	KNRIERVLGATLLPD HHHHHHHHHHCHHHH	4.90	-
786	Phosphorylation	IERVLGATLLPDLIQ HHHHHHHCHHHHHHH	27.33	-
797	Phosphorylation	DLIQKVLTFALSEEV HHHHHHHHHHHCCCC	15.17	24719451
801	Phosphorylation	KVLTFALSEEVRPQD HHHHHHHCCCCCCCC	28.42	20068231
809	Phosphorylation	EEVRPQDTVSVIGGV CCCCCCCCEEEEECC	14.94	20068231
811	Phosphorylation	VRPQDTVSVIGGVAG CCCCCCEEEEECCCC	15.31	20068231
820	Phosphorylation	IGGVAGGSKHGRKAA EECCCCCCHHHHHHH	22.14	20068231
821	Acetylation	GGVAGGSKHGRKAAW ECCCCCCHHHHHHHH	54.04	25953088
821	Malonylation	GGVAGGSKHGRKAAW ECCCCCCHHHHHHHH	54.04	26320211
829	Ubiquitination	HGRKAAWKFIKDNWE HHHHHHHHHHHHCHH	32.27	21890473
829	Acetylation	HGRKAAWKFIKDNWE HHHHHHHHHHHHCHH	32.27	25953088
829	Malonylation	HGRKAAWKFIKDNWE HHHHHHHHHHHHCHH	32.27	26320211
829	Ubiquitination	HGRKAAWKFIKDNWE HHHHHHHHHHHHCHH	32.27	21890473
832	Acetylation	KAAWKFIKDNWEELY HHHHHHHHHCHHHHH	48.41	23954790
832	Malonylation	KAAWKFIKDNWEELY HHHHHHHHHCHHHHH	48.41	26320211
832	Ubiquitination	KAAWKFIKDNWEELY HHHHHHHHHCHHHHH	48.41	-
842	Phosphorylation	WEELYNRYQGGFLIS HHHHHHHHHHCHHHH	14.10	20071362
855	Phosphorylation	ISRLIKLSVEGFAVD HHHHHHHHHCCEEHH	17.08	28188228
863	Acetylation	VEGFAVDKMAGEVKA HCCEEHHHHCHHHHH	24.85	26822725
863	Ubiquitination	VEGFAVDKMAGEVKA HCCEEHHHHCHHHHH	24.85	-
869	2-Hydroxyisobutyrylation	DKMAGEVKAFFESHP HHHCHHHHHHHHCCC	34.86	-
869	Ubiquitination	DKMAGEVKAFFESHP HHHCHHHHHHHHCCC	34.86	-
874	Phosphorylation	EVKAFFESHPAPSAE HHHHHHHCCCCCCHH	29.61	24719451
899	Acetylation	LLNAAWLKRDAESIH HHCHHHHHCCHHHHH	37.21	25953088
900	Methylation	LNAAWLKRDAESIHQ HCHHHHHCCHHHHHH	46.32	115485483
904	Phosphorylation	WLKRDAESIHQYLLQ HHHCCHHHHHHHHHH	27.39	26437602
908	Phosphorylation	DAESIHQYLLQRKAS CHHHHHHHHHHHCCC	8.67	28152594
915	Phosphorylation	YLLQRKASPPTV--- HHHHHCCCCCCC---	34.15	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBA6_HUMAN	UBA6	physical	22939629
STRAP_HUMAN	STRAP	physical	22939629
CNDP2_HUMAN	CNDP2	physical	22863883
SIAS_HUMAN	NANS	physical	22863883
PUR4_HUMAN	PFAS	physical	22863883
KS6A1_HUMAN	RPS6KA1	physical	22863883
KS6A3_HUMAN	RPS6KA3	physical	22863883
SCLY_HUMAN	SCLY	physical	22863883
NHRF1_HUMAN	SLC9A3R1	physical	22863883
TGM2_HUMAN	TGM2	physical	22863883
UBFD1_HUMAN	UBFD1	physical	22863883
ZN622_HUMAN	ZNF622	physical	22863883
IF6_HUMAN	EIF6	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48, AND MASS SPECTROMETRY.
PubMed: 19608861