HPS5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HPS5_HUMAN
• UniProt AC: Q9UPZ3
• Protein Name: Hermansky-Pudlak syndrome 5 protein
• Gene Name: HPS5
• Organism: Homo sapiens (Human).
• Sequence Length: 1129
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins..
• Protein Sequence: MAFVPVIPESYSHVLAEFESLDPLLSALRLDSSRLKCTSIAVSRKWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVACCLHDDDYVAVATSQGLVVVWELNQERRGKPEQMYVSSEHKGRRVTALCWDTAILRVFVGDHAGKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLISSLTRSFLCDTEREKFWKIGNKERDGEYGACFFPGRCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQFKKLLSLPPLPVITLRSEPQYDHTAGSSQSLSFPKLLHLSEHCVLTWTERGIYIFIPQNVQVLLWSEVKDIQDVAVCRNELFCLHLNGKVSHLSLISVERCVERLLRRGLWNLAARTCCLFQNSVIASRARKTLTADKLEHLKSQLDHGTYNDLISQLEELILKFEPLDSACSSRRSSISSHESFSILDSGIYRIISSRRGSQSDEDSCSLHSQTLSEDERFKEFTSQQEEDLPDQCCGSHGNEDNVSHAPVMFETDKNETFLPFGIPLPFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRPELRGDEQSCEEDVSSDTCPKEEDTEEEKEVTSPPPEEDRFQELKVATAEAMTKLQDPLVLFESESLRMVLQEWLSHLEKTFAMKDFSGVSDTDNSSMKLNQDVLLVNESKKGILDEDNEKEKRDSLGNEESVDKTACECVRSPRESLDDLFQICSPCAIASGLRNDLAELTTLCLELNVLNSKIKSTSGHVDHTLQQYSPEILACQFLKKYFFLLNLKRAKESIKLSYSNSPSVWDTFIEGLKEMASSNPVYMEMEKGDLPTRLKLLDDEVPFDSPLLVVYATRLYEKFGESALRSLIKFFPSILPSDIIQLCHHHPAEFLAYLDSLVKSRPEDQRSSFLESLLQPESLRLDWLLLAVSLDAPPSTSTMDDEGYPRPHSHLLSWGYSQLILHLIKLPADFITKEKMTDICRSCGFWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLIQSKSTRPAPQESLNGSLSDGPSPINVENVALLLAKAMGPDRAWSLLQECGLALELSEKFTRTCDILRIAEKRQRALIQSMLEKCDRFLWSQQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PVIPESYSHVLAEFE CCCCCCHHHHHHHHC	19.19	24719451
20	Phosphorylation	HVLAEFESLDPLLSA HHHHHHCCCHHHHHH	43.31	24719451
36	Ubiquitination	RLDSSRLKCTSIAVS CCCCCCCCCCEEEEE	34.06	29967540
37	Ubiquitination	LDSSRLKCTSIAVSR CCCCCCCCCEEEEEC	4.23	29967540
38	Phosphorylation	DSSRLKCTSIAVSRK CCCCCCCCEEEEECC	22.91	25072903
39	Phosphorylation	SSRLKCTSIAVSRKW CCCCCCCEEEEECCE	20.30	25072903
42	Ubiquitination	LKCTSIAVSRKWLAL CCCCEEEEECCEEEE	5.61	27667366
43	Phosphorylation	KCTSIAVSRKWLALG CCCEEEEECCEEEEC	21.08	25072903
61	Acetylation	GGLHLIQKEGWKHRL CCEEEEECCCCCEEE	51.72	25953088
95	Ubiquitination	DYVAVATSQGLVVVW CEEEEEECCCEEEEE	16.71	29967540
118	Phosphorylation	KPEQMYVSSEHKGRR CCHHEEECCCCCCCC	16.72	-
119	Ubiquitination	PEQMYVSSEHKGRRV CHHEEECCCCCCCCC	33.41	27667366
148	Ubiquitination	GDHAGKVSAIKLNTS CCCCCCEEEEEECCC	27.97	33845483
151	Ubiquitination	AGKVSAIKLNTSKQA CCCEEEEEECCCHHH	35.09	29967540
156	Ubiquitination	AIKLNTSKQAKAAAA EEEECCCHHHHHHHH	52.84	27667366
209	Ubiquitination	TEREKFWKIGNKERD CCCHHHHEECCCCCC	43.82	29967540
219	Phosphorylation	NKERDGEYGACFFPG CCCCCCCCEEEEECC	18.62	-
229	Phosphorylation	CFFPGRCSGGQQPLI EEECCCCCCCCCCEE	44.60	25159151
243	Phosphorylation	IYCARPGSRMWEVNF EEEECCCCEEEEEEC	22.96	20068231
256	Phosphorylation	NFDGEVISTHQFKKL ECCCCEEEHHHHHHH	25.64	20068231
257	Phosphorylation	FDGEVISTHQFKKLL CCCCEEEHHHHHHHH	14.47	20068231
262	Ubiquitination	ISTHQFKKLLSLPPL EEHHHHHHHHCCCCC	56.82	33845483
265	Phosphorylation	HQFKKLLSLPPLPVI HHHHHHHCCCCCCEE	49.63	-
273	Phosphorylation	LPPLPVITLRSEPQY CCCCCEEEECCCCCC	19.16	-
276	Phosphorylation	LPVITLRSEPQYDHT CCEEEECCCCCCCCC	57.66	24114839
280	Phosphorylation	TLRSEPQYDHTAGSS EECCCCCCCCCCCCC	22.02	24114839
283	Ubiquitination	SEPQYDHTAGSSQSL CCCCCCCCCCCCCCC	29.80	27667366
288	Ubiquitination	DHTAGSSQSLSFPKL CCCCCCCCCCCHHHH	50.52	29967540
289	Phosphorylation	HTAGSSQSLSFPKLL CCCCCCCCCCHHHHH	28.12	23312004
291	Phosphorylation	AGSSQSLSFPKLLHL CCCCCCCCHHHHHHH	44.76	23312004
305	Phosphorylation	LSEHCVLTWTERGIY HHCCCEEEEECCEEE	15.22	20068231
322	Phosphorylation	IPQNVQVLLWSEVKD ECCCCEEEEHHCCCC	1.96	32142685
325	Phosphorylation	NVQVLLWSEVKDIQD CCEEEEHHCCCCHHH	32.26	18669648
349	Phosphorylation	CLHLNGKVSHLSLIS EEEECCEECEEHHHC	4.64	33259812
360	Ubiquitination	SLISVERCVERLLRR HHHCHHHHHHHHHHC	2.06	27667366
391	Ubiquitination	VIASRARKTLTADKL HHHHHHHHHCCHHHH	47.07	-
397	Ubiquitination	RKTLTADKLEHLKSQ HHHCCHHHHHHHHHH	54.00	27667366
402	Ubiquitination	ADKLEHLKSQLDHGT HHHHHHHHHHHCCCC	37.76	29967540
420	Phosphorylation	LISQLEELILKFEPL HHHHHHHHHHHCCCC	3.97	32142685
429	Phosphorylation	LKFEPLDSACSSRRS HHCCCCCHHHHCCCC	38.57	28450419
429	Ubiquitination	LKFEPLDSACSSRRS HHCCCCCHHHHCCCC	38.57	21963094
432	Phosphorylation	EPLDSACSSRRSSIS CCCCHHHHCCCCCCC	26.96	29255136
433	Phosphorylation	PLDSACSSRRSSISS CCCHHHHCCCCCCCC	31.43	29255136
436	Phosphorylation	SACSSRRSSISSHES HHHHCCCCCCCCCCC	30.80	23927012
437	Phosphorylation	ACSSRRSSISSHESF HHHCCCCCCCCCCCE	25.36	23927012
439	Phosphorylation	SSRRSSISSHESFSI HCCCCCCCCCCCEEH	27.82	23927012
440	Phosphorylation	SRRSSISSHESFSIL CCCCCCCCCCCEEHH	29.60	23927012
442	Ubiquitination	RSSISSHESFSILDS CCCCCCCCCEEHHHH	56.26	29967540
443	Phosphorylation	SSISSHESFSILDSG CCCCCCCCEEHHHHH	20.90	23927012
445	Phosphorylation	ISSHESFSILDSGIY CCCCCCEEHHHHHHH	31.36	23663014
449	Phosphorylation	ESFSILDSGIYRIIS CCEEHHHHHHHHHHH	24.52	20068231
452	Phosphorylation	SILDSGIYRIISSRR EHHHHHHHHHHHCCC	10.17	23927012
453	Ubiquitination	ILDSGIYRIISSRRG HHHHHHHHHHHCCCC	20.17	29967540
456	Phosphorylation	SGIYRIISSRRGSQS HHHHHHHHCCCCCCC	18.54	24719451
457	Phosphorylation	GIYRIISSRRGSQSD HHHHHHHCCCCCCCC	18.65	24719451
461	Phosphorylation	IISSRRGSQSDEDSC HHHCCCCCCCCCCCC	25.38	23401153
463	Phosphorylation	SSRRGSQSDEDSCSL HCCCCCCCCCCCCCC	44.67	27273156
467	Phosphorylation	GSQSDEDSCSLHSQT CCCCCCCCCCCCCCC	11.98	29255136
469	Phosphorylation	QSDEDSCSLHSQTLS CCCCCCCCCCCCCCC	32.82	29255136
472	Phosphorylation	EDSCSLHSQTLSEDE CCCCCCCCCCCCCCH	30.10	23663014
474	Phosphorylation	SCSLHSQTLSEDERF CCCCCCCCCCCCHHH	34.95	23663014
476	Phosphorylation	SLHSQTLSEDERFKE CCCCCCCCCCHHHHH	46.52	23663014
500	Ubiquitination	PDQCCGSHGNEDNVS CCCCCCCCCCCCCCC	28.51	29967540
506	Ubiquitination	SHGNEDNVSHAPVMF CCCCCCCCCCCCEEE	7.40	21963094
509	Ubiquitination	NEDNVSHAPVMFETD CCCCCCCCCEEEECC	7.29	22817900
509 (in isoform 2)	Ubiquitination	-	7.29	21906983
532	Phosphorylation	GIPLPFRSPSPLVSL CCCCCCCCCCCCCCH	30.06	25159151
534	Phosphorylation	PLPFRSPSPLVSLQA CCCCCCCCCCCCHHH	31.92	23401153
535	Ubiquitination	LPFRSPSPLVSLQAV CCCCCCCCCCCHHHH	39.92	22817900
538	Phosphorylation	RSPSPLVSLQAVKES CCCCCCCCHHHHHHH	23.58	23927012
540	Ubiquitination	PSPLVSLQAVKESVS CCCCCCHHHHHHHHH	36.28	22817900
540 (in isoform 2)	Ubiquitination	-	36.28	21906983
543	Ubiquitination	LVSLQAVKESVSSFV CCCHHHHHHHHHHHH	47.49	21963094
545	Phosphorylation	SLQAVKESVSSFVRK CHHHHHHHHHHHHHH	22.91	23403867
547	Phosphorylation	QAVKESVSSFVRKTT HHHHHHHHHHHHHHH	27.60	23403867
548	Phosphorylation	AVKESVSSFVRKTTE HHHHHHHHHHHHHHH	26.13	23403867
556	Ubiquitination	FVRKTTEKIGTLHTS HHHHHHHHCCCCCCC	44.32	29967540
559	Phosphorylation	KTTEKIGTLHTSPDL HHHHHCCCCCCCCCC	20.88	28450419
562	Phosphorylation	EKIGTLHTSPDLKVR HHCCCCCCCCCCCCC	45.10	29255136
563	Phosphorylation	KIGTLHTSPDLKVRP HCCCCCCCCCCCCCH	12.98	29255136
566	Ubiquitination	TLHTSPDLKVRPELR CCCCCCCCCCCHHHC	6.66	29967540
567	Ubiquitination	LHTSPDLKVRPELRG CCCCCCCCCCHHHCC	43.51	29967540
578	Phosphorylation	ELRGDEQSCEEDVSS HHCCCCCCCCCCCCC	22.81	25849741
584	Phosphorylation	QSCEEDVSSDTCPKE CCCCCCCCCCCCCCC	34.51	30576142
585	Phosphorylation	SCEEDVSSDTCPKEE CCCCCCCCCCCCCCC	36.47	21815630
586	Ubiquitination	CEEDVSSDTCPKEED CCCCCCCCCCCCCCC	44.84	22817900
587	Phosphorylation	EEDVSSDTCPKEEDT CCCCCCCCCCCCCCC	32.43	30576142
590	Ubiquitination	VSSDTCPKEEDTEEE CCCCCCCCCCCCHHH	75.72	29967540
594	Phosphorylation	TCPKEEDTEEEKEVT CCCCCCCCHHHHCCC	48.88	30576142
601	Phosphorylation	TEEEKEVTSPPPEED CHHHHCCCCCCCCHH	36.29	22199227
602	Phosphorylation	EEEKEVTSPPPEEDR HHHHCCCCCCCCHHH	40.35	25159151
612	Ubiquitination	PEEDRFQELKVATAE CCHHHHHHHHHHHHH	48.09	22817900
614	Ubiquitination	EDRFQELKVATAEAM HHHHHHHHHHHHHHH	29.13	29967540
617	Ubiquitination	FQELKVATAEAMTKL HHHHHHHHHHHHHHC	28.19	22817900
622	Phosphorylation	VATAEAMTKLQDPLV HHHHHHHHHCCCCEE	35.33	28509920
623	Ubiquitination	ATAEAMTKLQDPLVL HHHHHHHHCCCCEEE	30.94	22817900
623 (in isoform 1)	Ubiquitination	-	30.94	21906983
649	Ubiquitination	EWLSHLEKTFAMKDF HHHHHHHHHHCCCCC	56.13	22817900
654	Ubiquitination	LEKTFAMKDFSGVSD HHHHHCCCCCCCCCC	52.79	22817900
654 (in isoform 1)	Ubiquitination	-	52.79	21906983
660	Phosphorylation	MKDFSGVSDTDNSSM CCCCCCCCCCCCCCC	38.01	25159151
662	Phosphorylation	DFSGVSDTDNSSMKL CCCCCCCCCCCCCCC	29.58	25159151
665	Phosphorylation	GVSDTDNSSMKLNQD CCCCCCCCCCCCCCC	34.32	25159151
666	Phosphorylation	VSDTDNSSMKLNQDV CCCCCCCCCCCCCCE	26.62	25159151
677	Ubiquitination	NQDVLLVNESKKGIL CCCEEEECCCCCCCC	48.03	27667366
679	Phosphorylation	DVLLVNESKKGILDE CEEEECCCCCCCCCC	34.17	29255136
680	Ubiquitination	VLLVNESKKGILDED EEEECCCCCCCCCCC	49.17	29967540
681	Ubiquitination	LLVNESKKGILDEDN EEECCCCCCCCCCCC	61.54	-
695	Phosphorylation	NEKEKRDSLGNEESV CHHHHHHHCCCHHHC	42.06	23401153
701	Phosphorylation	DSLGNEESVDKTACE HHCCCHHHCCHHHHH	29.45	23927012
704	Ubiquitination	GNEESVDKTACECVR CCHHHCCHHHHHHHC	35.55	29967540
712	Phosphorylation	TACECVRSPRESLDD HHHHHHCCCCCCHHH	14.12	28985074
721	Ubiquitination	RESLDDLFQICSPCA CCCHHHHHHHHHHHH	6.22	29967540
725	Phosphorylation	DDLFQICSPCAIASG HHHHHHHHHHHHHHC	25.33	21712546
744	Ubiquitination	LAELTTLCLELNVLN HHHHHHHHHHHHHHC	2.32	22817900
744 (in isoform 2)	Ubiquitination	-	2.32	21906983
754	Ubiquitination	LNVLNSKIKSTSGHV HHHHCHHHHCCCCCC	4.23	27667366
781	Phosphorylation	ACQFLKKYFFLLNLK HHHHHHHHHHHHHHH	9.66	25690035
791	Ubiquitination	LLNLKRAKESIKLSY HHHHHHHHHHHHCCC	56.90	27667366
817	Phosphorylation	EGLKEMASSNPVYME HHHHHHHHCCCEEEE	29.36	20068231
818	Phosphorylation	GLKEMASSNPVYMEM HHHHHHHCCCEEEEE	35.30	20068231
821	Ubiquitination	EMASSNPVYMEMEKG HHHHCCCEEEEEECC	9.22	22817900
822	Phosphorylation	MASSNPVYMEMEKGD HHHCCCEEEEEECCC	6.66	20068231
835	Ubiquitination	GDLPTRLKLLDDEVP CCCCCHHHHCCCCCC	43.65	29967540
858	Ubiquitination	YATRLYEKFGESALR HHHHHHHHHCHHHHH	45.15	22817900
858 (in isoform 1)	Ubiquitination	-	45.15	21906983
866	Phosphorylation	FGESALRSLIKFFPS HCHHHHHHHHHHHHH	34.98	24719451
1040	Phosphorylation	LHLIQSKSTRPAPQE HHHHHCCCCCCCCHH	34.59	28450419
1041	Phosphorylation	HLIQSKSTRPAPQES HHHHCCCCCCCCHHH	44.39	28450419
1048	Phosphorylation	TRPAPQESLNGSLSD CCCCCHHHHCCCCCC	23.14	28450419
1052	Phosphorylation	PQESLNGSLSDGPSP CHHHHCCCCCCCCCC	24.51	28450419
1054	Phosphorylation	ESLNGSLSDGPSPIN HHHCCCCCCCCCCCC	42.07	28450419
1058	Phosphorylation	GSLSDGPSPINVENV CCCCCCCCCCCHHHH	43.89	28348404
1080	Phosphorylation	MGPDRAWSLLQECGL HCCHHHHHHHHHHCH	20.44	20068231
1115	Phosphorylation	RQRALIQSMLEKCDR HHHHHHHHHHHHHHH	20.52	30266825
1119	Ubiquitination	LIQSMLEKCDRFLWS HHHHHHHHHHHHHHH	37.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HPS5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HPS5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HPS5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HPS5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614074: Hermansky-Pudlak syndrome 5 (HPS5)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534, AND MASSSPECTROMETRY.
PubMed: 19690332

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-562 AND SER-563, ANDMASS SPECTROMETRY.
PubMed: 18220336

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-695, AND MASSSPECTROMETRY.
PubMed: 19007248

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-461, AND MASSSPECTROMETRY.
PubMed: 17525332