PEX10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEX10_HUMAN
• UniProt AC: O60683
• Protein Name: Peroxisome biogenesis factor 10
• Gene Name: PEX10
• Organism: Homo sapiens (Human).
• Sequence Length: 326
• Subcellular Localization: Peroxisome membrane ; Peripheral membrane protein .
• Protein Description: Somewhat implicated in the biogenesis of peroxisomes..
• Protein Sequence: MAPAAASPPEVIRAAQKDEYYRGGLRSAAGGALHSLAGARKWLEWRKEVELLSDVAYFGLTTLAGYQTLGEEYVSIIQVDPSRIHVPSSLRRGVLVTLHAVLPYLLDKALLPLEQELQADPDSGRPLQGSLGPGGRGCSGARRWMRHHTATLTEQQRRALLRAVFVLRQGLACLQRLHVAWFYIHGVFYHLAKRLTGITYLRVRSLPGEDLRARVSYRLLGVISLLHLVLSMGLQLYGFRQRQRARKEWRLHRGLSHRRASLEERAVSRNPLCTLCLEERRHPTATPCGHLFCWECITAWCSSKAECPLCREKFPPQKLIYLRHYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAPAAASPPEVIRA -CCCCCCCCHHHHHH	35.94	29255136
17	Ubiquitination	EVIRAAQKDEYYRGG HHHHHHHCCHHHHHC	48.04	-
17 (in isoform 2)	Ubiquitination	-	48.04	-
27	Phosphorylation	YYRGGLRSAAGGALH HHHHCHHHHHHHHHH	27.75	24719451
89	Phosphorylation	SRIHVPSSLRRGVLV HHCCCCCHHHHCCCH	21.59	17081983
136	Methylation	GSLGPGGRGCSGARR CCCCCCCCCCHHHHH	49.19	115487031
149	Phosphorylation	RRWMRHHTATLTEQQ HHHHHHHCCCCCHHH	18.40	30576142
153	Phosphorylation	RHHTATLTEQQRRAL HHHCCCCCHHHHHHH	27.65	30576142
196	Phosphorylation	YHLAKRLTGITYLRV HHHHHHHHCCEEEEE	30.48	22210691
199	Phosphorylation	AKRLTGITYLRVRSL HHHHHCCEEEEEECC	20.18	22210691
200	Phosphorylation	KRLTGITYLRVRSLP HHHHCCEEEEEECCC	7.21	22210691
216	Phosphorylation	EDLRARVSYRLLGVI HHHHHHHHHHHHHHH	10.05	23828894
261	Phosphorylation	GLSHRRASLEERAVS HHCHHHHCHHHHHHH	34.21	27794612
281	Phosphorylation	TLCLEERRHPTATPC HHHHHCCCCCCCCCC	43.34	24719451
321	Phosphorylation	FPPQKLIYLRHYR-- CCCCCEEEEEECC--	14.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEX10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEX10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEX10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEX12_HUMAN	PEX12	physical	10837480
PEX10_HUMAN	PEX10	physical	10837480
PEX5_HUMAN	PEX5	physical	10837480
PEX12_HUMAN	PEX12	physical	12096124
PEX19_HUMAN	PEX19	physical	12096124
PEX10_HUMAN	PEX10	physical	22493164

Drug and Disease Associations

• Kegg Disease
• H00205: Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NAL
• OMIM Disease
• 614870: Peroxisome biogenesis disorder complementation group 7 (PBD-CG7)
• 614870: Peroxisome biogenesis disorder 6A (PBD6A)
• 614871: Peroxisome biogenesis disorder 6B (PBD6B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.