PEX12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEX12_HUMAN
• UniProt AC: O00623
• Protein Name: Peroxisome assembly protein 12
• Gene Name: PEX12
• Organism: Homo sapiens (Human).
• Sequence Length: 359
• Subcellular Localization: Peroxisome membrane ; Multi-pass membrane protein .
• Protein Description: Required for protein import into peroxisomes..
• Protein Sequence: MAEHGAHFTAASVADDQPSIFEVVAQDSLMTAVRPALQHVVKVLAESNPTHYGFLWRWFDEIFTLLDLLLQQHYLSRTSASFSENFYGLKRIVMGDTHKSQRLASAGLPKQQLWKSIMFLVLLPYLKVKLEKLVSSLREEDEYSIHPPSSRWKRFYRAFLAAYPFVNMAWEGWFLVQQLRYILGKAQHHSPLLRLAGVQLGRLTVQDIQALEHKPAKASMMQQPARSVSEKINSALKKAVGGVALSLSTGLSVGVFFLQFLDWWYSSENQETIKSLTALPTPPPPVHLDYNSDSPLLPKMKTVCPLCRKTRVNDTVLATSGYVFCYRCVFHYVRSHQACPITGYPTEVQHLIKLYSPEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Acetylation	IVMGDTHKSQRLASA EECCCCHHHHHHHHC	50.83	25953088
100	Phosphorylation	VMGDTHKSQRLASAG ECCCCHHHHHHHHCC	16.96	23403867
105	Phosphorylation	HKSQRLASAGLPKQQ HHHHHHHHCCCCHHH	27.71	23403867
116	Phosphorylation	PKQQLWKSIMFLVLL CHHHHHHHHHHHHHH	14.01	29759185
132	Acetylation	YLKVKLEKLVSSLRE HHHHHHHHHHHHCCC	65.70	18527107
135	Phosphorylation	VKLEKLVSSLREEDE HHHHHHHHHCCCCCC	33.81	24719451
136	Phosphorylation	KLEKLVSSLREEDEY HHHHHHHHCCCCCCC	24.78	24719451
190	Phosphorylation	LGKAQHHSPLLRLAG HHHHCCCCHHHHHHC	18.34	24719451
219	Phosphorylation	EHKPAKASMMQQPAR HCCCCHHHHCCCCCH	17.68	24719451
231	Acetylation	PARSVSEKINSALKK CCHHHHHHHHHHHHH	39.42	19811403
237	Acetylation	EKINSALKKAVGGVA HHHHHHHHHHHHHHH	38.10	19811411
275	Phosphorylation	ENQETIKSLTALPTP CCHHHHHHHCCCCCC	27.40	-
277	Phosphorylation	QETIKSLTALPTPPP HHHHHHHCCCCCCCC	32.99	-
281	Phosphorylation	KSLTALPTPPPPVHL HHHCCCCCCCCCCCC	49.64	-
292	Phosphorylation	PVHLDYNSDSPLLPK CCCCCCCCCCCCCCC	32.98	28348404
294	Phosphorylation	HLDYNSDSPLLPKMK CCCCCCCCCCCCCCC	19.78	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEX12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEX12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEX12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEX5_HUMAN	PEX5	physical	10562279
PEX5_HUMAN	PEX5	physical	10837480
PEX10_HUMAN	PEX10	physical	10562279
PEX10_HUMAN	PEX10	physical	10837480
PEX5_HUMAN	PEX5	physical	12456682
PEX19_HUMAN	PEX19	physical	12096124
PEX5_HUMAN	PEX5	physical	12096124
PEX10_HUMAN	PEX10	physical	12096124

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.