H3C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H3C_HUMAN
• UniProt AC: Q6NXT2
• Protein Name: Histone H3.3C
• Gene Name: H3F3C
• Organism: Homo sapiens (Human).
• Sequence Length: 135
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes..
• Protein Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSTPSTCGVKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFNTDLRFQSAAVGALQEASEAYLVGLLEDTNLCAIHAKRVTIMPKDIQLARRIRGERA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Asymmetric dimethylarginine	-----MARTKQTARK -----CCCCCHHHHH	40.95	-
3	Citrullination	-----MARTKQTARK -----CCCCCHHHHH	40.95	-
3	Methylation	-----MARTKQTARK -----CCCCCHHHHH	40.95	-
4	Phosphorylation	----MARTKQTARKS ----CCCCCHHHHHH	20.26	17938195
5	Allysine	---MARTKQTARKST ---CCCCCHHHHHHC	39.85	-
5	Acetylation	---MARTKQTARKST ---CCCCCHHHHHHC	39.85	-
5	Deamination	---MARTKQTARKST ---CCCCCHHHHHHC	39.85	-
5	Methylation	---MARTKQTARKST ---CCCCCHHHHHHC	39.85	-
5	Other	---MARTKQTARKST ---CCCCCHHHHHHC	39.85	-
6	Formation of an isopeptide bond	--MARTKQTARKSTG --CCCCCHHHHHHCC	39.52	-
6	Serotonylation	--MARTKQTARKSTG --CCCCCHHHHHHCC	39.52	-
7	Phosphorylation	-MARTKQTARKSTGG -CCCCCHHHHHHCCC	29.95	20228790
9	Citrullination	ARTKQTARKSTGGKA CCCCHHHHHHCCCCC	36.52	-
9	Citrullination	ARTKQTARKSTGGKA CCCCHHHHHHCCCCC	36.52	-
9	Methylation	ARTKQTARKSTGGKA CCCCHHHHHHCCCCC	36.52	-
10	"N6,N6,N6-trimethyllysine"	RTKQTARKSTGGKAP CCCHHHHHHCCCCCC	50.32	-
10	Acetylation	RTKQTARKSTGGKAP CCCHHHHHHCCCCCC	50.32	54236075
10	Lactoylation	RTKQTARKSTGGKAP CCCHHHHHHCCCCCC	50.32	-
10	Methylation	RTKQTARKSTGGKAP CCCHHHHHHCCCCCC	50.32	-
10	Other	RTKQTARKSTGGKAP CCCHHHHHHCCCCCC	50.32	-
10	Ubiquitination	RTKQTARKSTGGKAP CCCHHHHHHCCCCCC	50.32	22817900
11	ADP-ribosylation	TKQTARKSTGGKAPR CCHHHHHHCCCCCCH	27.08	-
11	Phosphorylation	TKQTARKSTGGKAPR CCHHHHHHCCCCCCH	27.08	10469656
12	Phosphorylation	KQTARKSTGGKAPRK CHHHHHHCCCCCCHH	53.65	26074081
15	Sumoylation	ARKSTGGKAPRKQLA HHHHCCCCCCHHHHH	57.47	-
15	Acetylation	ARKSTGGKAPRKQLA HHHHCCCCCCHHHHH	57.47	54236071
15	Glutarylation	ARKSTGGKAPRKQLA HHHHCCCCCCHHHHH	57.47	-
15	Lactoylation	ARKSTGGKAPRKQLA HHHHCCCCCCHHHHH	57.47	-
15	Other	ARKSTGGKAPRKQLA HHHHCCCCCCHHHHH	57.47	-
15	Succinylation	ARKSTGGKAPRKQLA HHHHCCCCCCHHHHH	57.47	21890473
15	Sumoylation	ARKSTGGKAPRKQLA HHHHCCCCCCHHHHH	57.47	-
15	Ubiquitination	ARKSTGGKAPRKQLA HHHHCCCCCCHHHHH	57.47	23000965
18	Asymmetric dimethylarginine	STGGKAPRKQLATKA HCCCCCCHHHHHHHH	44.18	-
18	Citrullination	STGGKAPRKQLATKA HCCCCCCHHHHHHHH	44.18	-
18	Methylation	STGGKAPRKQLATKA HCCCCCCHHHHHHHH	44.18	-
19	Sumoylation	TGGKAPRKQLATKAA CCCCCCHHHHHHHHH	48.91	-
19	Acetylation	TGGKAPRKQLATKAA CCCCCCHHHHHHHHH	48.91	66741851
19	Butyrylation	TGGKAPRKQLATKAA CCCCCCHHHHHHHHH	48.91	-
19	Glutarylation	TGGKAPRKQLATKAA CCCCCCHHHHHHHHH	48.91	-
19	Lactoylation	TGGKAPRKQLATKAA CCCCCCHHHHHHHHH	48.91	-
19	Methylation	TGGKAPRKQLATKAA CCCCCCHHHHHHHHH	48.91	-
19	Other	TGGKAPRKQLATKAA CCCCCCHHHHHHHHH	48.91	-
19	Sumoylation	TGGKAPRKQLATKAA CCCCCCHHHHHHHHH	48.91	-
19	Ubiquitination	TGGKAPRKQLATKAA CCCCCCHHHHHHHHH	48.91	23000965
24	Sumoylation	PRKQLATKAARKSTP CHHHHHHHHHHHCCC	34.15	-
24	Acetylation	PRKQLATKAARKSTP CHHHHHHHHHHHCCC	34.15	66724869
24	Butyrylation	PRKQLATKAARKSTP CHHHHHHHHHHHCCC	34.15	-
24	Glutarylation	PRKQLATKAARKSTP CHHHHHHHHHHHCCC	34.15	-
24	Lactoylation	PRKQLATKAARKSTP CHHHHHHHHHHHCCC	34.15	-
24	Methylation	PRKQLATKAARKSTP CHHHHHHHHHHHCCC	34.15	-
24	Other	PRKQLATKAARKSTP CHHHHHHHHHHHCCC	34.15	-
24	Sumoylation	PRKQLATKAARKSTP CHHHHHHHHHHHCCC	34.15	-
24	Ubiquitination	PRKQLATKAARKSTP CHHHHHHHHHHHCCC	34.15	23000965
27	Citrullination	QLATKAARKSTPSTC HHHHHHHHHCCCCCC	38.01	-
27	Citrullination	QLATKAARKSTPSTC HHHHHHHHHCCCCCC	38.01	-
28	"N6,N6,N6-trimethyllysine"	LATKAARKSTPSTCG HHHHHHHHCCCCCCC	54.69	-
28	Acetylation	LATKAARKSTPSTCG HHHHHHHHCCCCCCC	54.69	-
28	Glutarylation	LATKAARKSTPSTCG HHHHHHHHCCCCCCC	54.69	-
28	Lactoylation	LATKAARKSTPSTCG HHHHHHHHCCCCCCC	54.69	-
28	Methylation	LATKAARKSTPSTCG HHHHHHHHCCCCCCC	54.69	-
28	Other	LATKAARKSTPSTCG HHHHHHHHCCCCCCC	54.69	-
28	Ubiquitination	LATKAARKSTPSTCG HHHHHHHHCCCCCCC	54.69	22817900
29	ADP-ribosylation	ATKAARKSTPSTCGV HHHHHHHCCCCCCCC	39.74	-
29	Phosphorylation	ATKAARKSTPSTCGV HHHHHHHCCCCCCCC	39.74	-
32	Phosphorylation	AARKSTPSTCGVKPH HHHHCCCCCCCCCCC	36.10	-
37	Methylation	TPSTCGVKPHRYRPG CCCCCCCCCCCCCCC	22.01	-
41	Phosphorylation	CGVKPHRYRPGTVAL CCCCCCCCCCCCHHH	20.37	28152594
42	Methylation	GVKPHRYRPGTVALR CCCCCCCCCCCHHHH	24.11	-
45	Phosphorylation	PHRYRPGTVALREIR CCCCCCCCHHHHHHH	12.80	30266825
49	Methylation	RPGTVALREIRRYQK CCCCHHHHHHHHHHH	27.79	-
54	Phosphorylation	ALREIRRYQKSTELL HHHHHHHHHHCHHHH	15.50	22817900
56	"N6,N6,N6-trimethyllysine"	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
56	Acetylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	66739507
56	Glutarylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
56	Lactoylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
56	Methylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
56	Other	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
56	Succinylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	21890473
56	Sumoylation	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	-
56	Ubiquitination	REIRRYQKSTELLIR HHHHHHHHCHHHHHH	50.87	23000965
57	Phosphorylation	EIRRYQKSTELLIRK HHHHHHHCHHHHHHH	16.16	23401153
58	Phosphorylation	IRRYQKSTELLIRKL HHHHHHCHHHHHHHC	37.37	30266825
63	Methylation	KSTELLIRKLPFQRL HCHHHHHHHCCHHHH	34.13	-
64	Methylation	STELLIRKLPFQRLV CHHHHHHHCCHHHHH	54.22	-
64	Other	STELLIRKLPFQRLV CHHHHHHHCCHHHHH	54.22	-
80	O-linked_Glycosylation	EIAQDFNTDLRFQSA HHHHHCCCCHHHHHH	36.08	21224338
80	Phosphorylation	EIAQDFNTDLRFQSA HHHHHCCCCHHHHHH	36.08	20850016
86	Phosphorylation	NTDLRFQSAAVGALQ CCCHHHHHHHHHHHH	18.58	-
107	Phosphorylation	LVGLLEDTNLCAIHA HHHHHCCCCCEEEEE	22.25	-
115	Acetylation	NLCAIHAKRVTIMPK CCEEEEEEECEECHH	32.99	-
115	Glutarylation	NLCAIHAKRVTIMPK CCEEEEEEECEECHH	32.99	-
118	Phosphorylation	AIHAKRVTIMPKDIQ EEEEEECEECHHHHH	18.65	20068231
122	Sumoylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	-
122	Acetylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	54236079
122	Glutarylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	-
122	Methylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	-
122	Other	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	-
122	Succinylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	21890473
122	Sumoylation	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	-
122	Ubiquitination	KRVTIMPKDIQLARR EECEECHHHHHHHHH	50.51	23000965
128	Methylation	PKDIQLARRIRGERA HHHHHHHHHHHCCCC	43.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4	T	Phosphorylation	Kinase	HASPIN	Q8TF76	Uniprot
7	T	Phosphorylation	Kinase	PKC	-	Uniprot
11	S	Phosphorylation	Kinase	ALTERNATE	-	Uniprot
12	T	Phosphorylation	Kinase	PKC	-	Uniprot
29	S	Phosphorylation	Kinase	ALTERNATE	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
3	R	Methylation	Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3).	-
4	T	Phosphorylation	Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase.	-
5	K	ubiquitylation	Methylation at Lys-5 (H3K4me) requires preliminary monoubiquitination of H2B at 'Lys-120'.	-
5	K	Acetylation	Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4.	-
5	K	Methylation	Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3).	-
5	K	Methylation	Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4.	-
5	K	Methylation	Methylation at Lys-5 (H3K4me) is linked to gene activation.	-
5	K	Methylation	Methylation at Lys-5 (H3K4me) requires preliminary monoubiquitination of H2B at 'Lys-120'.	-
5	K	Phosphorylation	Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A.	-
5	K	Methylation	Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A.	-
7	T	Phosphorylation	Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A.	-
7	T	Methylation	Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A.	-
9	R	Methylation	Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression.	-
9	R	Methylation	Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.	-
9	R	Methylation	Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s).	-
9	R	Citrullination	Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.	-
9	R	Acetylation	Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s).	-
10	K	Phosphorylation	Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.	-
10	K	Phosphorylation	Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).	30257210
10	K	Phosphorylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
10	K	Phosphorylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
10	K	Methylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
10	K	Methylation	Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.	-
10	K	Methylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
10	K	Acetylation	Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s).	-
10	K	Acetylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
10	K	Acetylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
10	K	Acetylation	Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).	30257210
10	K	Methylation	Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s).	-
10	K	Methylation	Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.	-
10	K	Methylation	Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression.	-
11	S	Acetylation	Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).	30257210
11	S	Acetylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
11	S	Acetylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
11	S	Methylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
11	S	Methylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
11	S	Phosphorylation	In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun.	-
11	S	Phosphorylation	Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4.	-
11	S	Phosphorylation	Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis.	-
11	S	Phosphorylation	Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin.	-
11	S	Phosphorylation	Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation.	-
11	S	Phosphorylation	Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4.	-
11	S	Phosphorylation	Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).	30257210
12	T	Phosphorylation	Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.	-
12	T	Methylation	Phosphorylation at Thr-12 (H3T11ph) by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.	-
12	T	Phosphorylation	At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1.	-
18	R	Citrullination	Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.	-
18	R	Methylation	Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription.	-
18	R	Methylation	Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation.	-
18	R	Methylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	-
18	R	Acetylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	-
19	K	Methylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	-
19	K	Acetylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	-
24	K	Methylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	-
24	K	Acetylation	Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me).	-
28	K	Methylation	Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression.	-
28	K	Methylation	Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.	-
29	S	Phosphorylation	Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation.	-
56	K	Methylation	Monomethylation at Lys-56 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication (By similarity).	-
120	K	ubiquitylation	Methylation at Lys-5 (H3K4me) requires preliminary monoubiquitination of H2B at 'Lys-120'.	-
120	K	Methylation	Methylation at Lys-5 (H3K4me) requires preliminary monoubiquitination of H2B at 'Lys-120'.	-
122	K	Succinylation	Desuccinylation at Lys-122 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair.	-
122	K	Acetylation	Acetylation at Lys-122 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H3C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
KDM4B_HUMAN	KDM4B	physical	23455924
ANM5_HUMAN	PRMT5	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
ANM7_HUMAN	PRMT7	physical	23455924
SETMR_HUMAN	SETMAR	physical	23455924
SMYD1_HUMAN	SMYD1	physical	23455924
SMYD3_HUMAN	SMYD3	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
NSD3_HUMAN	WHSC1L1	physical	23455924

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-10; LYS-15; LYS-19; LYS-24;LYS-56 AND LYS-122, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative interaction proteomics and genome-wide profiling ofepigenetic histone marks and their readers.";
Vermeulen M., Eberl H.C., Matarese F., Marks H., Denissov S.,Butter F., Lee K.K., Olsen J.V., Hyman A.A., Stunnenberg H.G.,Mann M.;
Cell 142:967-980(2010).
Cited for: PHOSPHORYLATION AT SER-57 AND THR-80.
PubMed: 20850016