SMYD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMYD1_HUMAN
• UniProt AC: Q8NB12
• Protein Name: Histone-lysine N-methyltransferase SMYD1
• Gene Name: SMYD1
• Organism: Homo sapiens (Human).
• Sequence Length: 490
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis..
• Protein Sequence: MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQEKLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKRYGKVPNENIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKDDLFLGVKDNPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLSIVSEVLSYLQAFEEASFYARRMVDGYMKLYHPNNAQLGMAVMRAGLTNWHAGNIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQVMAEPSNEPSPALFHKKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	O-linked_Glycosylation	------MTIGRMENV ------CCCCCCCCE	31.94	30379171
39	Phosphorylation	IIFAERAYSAVVFDS HHHHHHHHHHHHHHH	11.90	-
40	Phosphorylation	IFAERAYSAVVFDSL HHHHHHHHHHHHHHH	17.38	-
46	Phosphorylation	YSAVVFDSLVNFVCH HHHHHHHHHHHHHHH	23.81	-
54	Phosphorylation	LVNFVCHTCFKRQEK HHHHHHHHHHHHHHH	17.95	-
91	Phosphorylation	LNHKNECSAIKRYGK HCCCCCHHHHHHHCC	27.18	26437602
128	Phosphorylation	LTEGCLVSVDDLQNH CCCCEEEEHHHHHHH	13.59	-
226	Phosphorylation	GNHEAVKSMFHTQMR CCHHHHHHHHHHHHH	21.78	26437602
298	Phosphorylation	VKDNPKPSQEVVKEM CCCCCCCCHHHHHHH	45.13	26437602
309	Phosphorylation	VKEMIQFSKDTLEKI HHHHHHHCHHHHHHH	17.16	26503514
312	Phosphorylation	MIQFSKDTLEKIDKA HHHHCHHHHHHHHHH	40.32	26503514
321	Phosphorylation	EKIDKARSEGLYHEV HHHHHHHHCCHHHHH	40.66	26437602
325	Phosphorylation	KARSEGLYHEVVKLC HHHHCCHHHHHHHHH	13.54	25404012
346	Phosphorylation	QEPVFADTNIYMLRM CCCCCCCCHHHHHHH	21.78	22673903
349	Phosphorylation	VFADTNIYMLRMLSI CCCCCHHHHHHHHHH	7.68	26437602
355	Phosphorylation	IYMLRMLSIVSEVLS HHHHHHHHHHHHHHH	16.17	25262027
358	Phosphorylation	LRMLSIVSEVLSYLQ HHHHHHHHHHHHHHH	21.96	25262027
362	Phosphorylation	SIVSEVLSYLQAFEE HHHHHHHHHHHHHHH	29.04	25262027
363	Phosphorylation	IVSEVLSYLQAFEEA HHHHHHHHHHHHHHH	9.93	25262027
371	Phosphorylation	LQAFEEASFYARRMV HHHHHHHHHHHHHHH	23.28	25262027
373	Phosphorylation	AFEEASFYARRMVDG HHHHHHHHHHHHHCC	9.19	25262027
381	Phosphorylation	ARRMVDGYMKLYHPN HHHHHCCCHHEECCC	6.14	23607784
385	Phosphorylation	VDGYMKLYHPNNAQL HCCCHHEECCCHHHH	15.09	23607784

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMYD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMYD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMYD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCRN3_HUMAN	SCRN3	physical	28514442
PURA2_HUMAN	ADSS	physical	28514442
SPSB3_HUMAN	SPSB3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.