PHKG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHKG1_HUMAN
• UniProt AC: Q16816
• Protein Name: Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
• Gene Name: PHKG1
• Organism: Homo sapiens (Human).
• Sequence Length: 387
• Protein Description: Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity)..
• Protein Sequence: MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFSPRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEEDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	EILGRGVSSVVRRCI HHHCCCHHHHHHHHC	21.90	7935360
32	Phosphorylation	ILGRGVSSVVRRCIH HHCCCHHHHHHHHCC	23.40	-
46	Phosphorylation	HKPTSQEYAVKVIDV CCCCCCCEEEEEEEC	14.73	26437602
82	Phosphorylation	VDILRKVSGHPNIIQ HHHHHHHCCCCCEEE	34.12	7935360
96	Phosphorylation	QLKDTYETNTFFFLV EEECCCCCCCCHHHH	29.19	29759185
98	Phosphorylation	KDTYETNTFFFLVFD ECCCCCCCCHHHHHH	29.28	29759185
140	Phosphorylation	ALLEVICTLHKLNIV HHHHHHHHHHHCCCC	22.29	-
199	Phosphorylation	APEIIECSMNEDHPG CHHHHCCCCCCCCCC	16.32	22210691
207	Phosphorylation	MNEDHPGYGKEVDMW CCCCCCCCCCCCHHH	29.49	22210691
262	Acetylation	DDYSDTVKDLVSRFL CCCHHHHHHHHHHHC	47.65	7662999
304	Methylation	RHFSPRGKFKVIALT HHCCCCCCCEEEEEH	43.20	23644510
329	Phosphorylation	YRRVKPVTREIVIRD HCCCCCCEEEEEECC	30.98	-
338	Phosphorylation	EIVIRDPYALRPLRR EEEECCHHHHHHHHH	23.66	18083107
350	Phosphorylation	LRRLIDAYAFRIYGH HHHHHHHHHHHHHHH	11.52	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
31	S	Phosphorylation	Kinase	PHK-FAMILY	-	GPS
31	S	Phosphorylation	Kinase	PHK_GROUP	-	PhosphoELM
82	S	Phosphorylation	Kinase	PHK-FAMILY	-	GPS
82	S	Phosphorylation	Kinase	PHK_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHKG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHKG1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PHKG1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.