NSUN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSUN4_HUMAN
• UniProt AC: Q96CB9
• Protein Name: 5-methylcytosine rRNA methyltransferase NSUN4
• Gene Name: NSUN4
• Organism: Homo sapiens (Human).
• Sequence Length: 384
• Subcellular Localization: Mitochondrion .
• Protein Description: Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4..
• Protein Sequence: MAALTLRGVRELLKRVDLATVPRRHRYKKKWAATEPKFPAVRLALQNFDMTYSVQFGDLWPSIRVSLLSEQKYGALVNNFAAWDHVSAKLEQLSAKDFVNEAISHWELQSEGGQSAAPSPASWACSPNLRCFTFDRGDISRFPPARPGSLGVMEYYLMDAASLLPVLALGLQPGDIVLDLCAAPGGKTLALLQTGCCRNLAANDLSPSRIARLQKILHSYVPEEIRDGNQVRVTSWDGRKWGELEGDTYDRVLVDVPCTTDRHSLHEEENNIFKRSRKKERQILPVLQVQLLAAGLLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQVQVEDLTHFRRVFMDTFCFFSSCQVGELVIPNLMANFGPMYFCKMRRLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAALTLRGVREL ---CCHHHHHHHHHH	15.07	23403867
20	Phosphorylation	LKRVDLATVPRRHRY HHHCCCCCCCCCCCC	38.04	24719451
34	Phosphorylation	YKKKWAATEPKFPAV CCCCCCCCCCCCHHH	45.10	28555341
37	Ubiquitination	KWAATEPKFPAVRLA CCCCCCCCCHHHHHH	58.72	21890473
37 (in isoform 2)	Ubiquitination	-	58.72	21890473
37 (in isoform 1)	Ubiquitination	-	58.72	21890473
37	Ubiquitination	KWAATEPKFPAVRLA CCCCCCCCCHHHHHH	58.72	21890473
37	Ubiquitination	KWAATEPKFPAVRLA CCCCCCCCCHHHHHH	58.72	21890473
42 (in isoform 3)	Ubiquitination	-	19.15	21890473
76 (in isoform 3)	Ubiquitination	-	3.53	21890473
198	Methylation	LLQTGCCRNLAANDL HHHHCCCCHHHCCCC	45.32	115485663
206	Phosphorylation	NLAANDLSPSRIARL HHHCCCCCHHHHHHH	24.56	19664994
208	Phosphorylation	AANDLSPSRIARLQK HCCCCCHHHHHHHHH	32.70	30266825
215	Malonylation	SRIARLQKILHSYVP HHHHHHHHHHHHHCC	52.40	26320211
215	Ubiquitination	SRIARLQKILHSYVP HHHHHHHHHHHHHCC	52.40	21890473
215	Ubiquitination	SRIARLQKILHSYVP HHHHHHHHHHHHHCC	52.40	21890473
215	Ubiquitination	SRIARLQKILHSYVP HHHHHHHHHHHHHCC	52.40	21890473
215 (in isoform 1)	Ubiquitination	-	52.40	21890473
219	Phosphorylation	RLQKILHSYVPEEIR HHHHHHHHHCCHHHC	25.12	19835603
220	Phosphorylation	LQKILHSYVPEEIRD HHHHHHHHCCHHHCC	14.85	19835603
240	Ubiquitination	VTSWDGRKWGELEGD EEECCCCCCEECCCC	66.15	21890473
240 (in isoform 1)	Ubiquitination	-	66.15	21890473
240	Ubiquitination	VTSWDGRKWGELEGD EEECCCCCCEECCCC	66.15	21890473
240	Ubiquitination	VTSWDGRKWGELEGD EEECCCCCCEECCCC	66.15	21890473
274	Ubiquitination	EEENNIFKRSRKKER HHHCCHHHHCHHHHH	45.74	21890473
274	Ubiquitination	EEENNIFKRSRKKER HHHCCHHHHCHHHHH	45.74	21890473
274 (in isoform 1)	Ubiquitination	-	45.74	21890473
274	Ubiquitination	EEENNIFKRSRKKER HHHCCHHHHCHHHHH	45.74	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSUN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSUN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSUN4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NSUN4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.