MGST1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGST1_HUMAN
• UniProt AC: P10620
• Protein Name: Microsomal glutathione S-transferase 1
• Gene Name: MGST1
• Organism: Homo sapiens (Human).
• Sequence Length: 155
• Subcellular Localization: Microsome. Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity..
• Protein Sequence: MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAKKYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIAYLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Sulfoxidation	MVDLTQVMDDEVFMA CCCHHHCCCHHHHHH	3.75	28183972
14	Sulfoxidation	VMDDEVFMAFASYAT CCCHHHHHHHHHHHH	3.47	28183972
18	Phosphorylation	EVFMAFASYATIILS HHHHHHHHHHHHHHH	14.62	30206219
19	Phosphorylation	VFMAFASYATIILSK HHHHHHHHHHHHHHH	12.34	23403867
21	Phosphorylation	MAFASYATIILSKMM HHHHHHHHHHHHHHH	10.58	23403867
25	Phosphorylation	SYATIILSKMMLMST HHHHHHHHHHHHHHH	14.22	22210691
31	Phosphorylation	LSKMMLMSTATAFYR HHHHHHHHHHHHHHH	15.78	23403867
32	Phosphorylation	SKMMLMSTATAFYRL HHHHHHHHHHHHHHH	17.67	23403867
34	Phosphorylation	MMLMSTATAFYRLTR HHHHHHHHHHHHHHH	19.86	20860994
37	Phosphorylation	MSTATAFYRLTRKVF HHHHHHHHHHHHHHH	11.40	22461510
40	Phosphorylation	ATAFYRLTRKVFANP HHHHHHHHHHHHCCH	21.31	-
42	Malonylation	AFYRLTRKVFANPED HHHHHHHHHHCCHHH	36.15	26320211
42	2-Hydroxyisobutyrylation	AFYRLTRKVFANPED HHHHHHHHHHCCHHH	36.15	-
42	Acetylation	AFYRLTRKVFANPED HHHHHHHHHHCCHHH	36.15	25825284
50	S-nitrosylation	VFANPEDCVAFGKGE HHCCHHHHHHCCCCC	1.96	22178444
50	S-nitrosocysteine	VFANPEDCVAFGKGE HHCCHHHHHHCCCCC	1.96	-
55	Ubiquitination	EDCVAFGKGENAKKY HHHHHCCCCCCHHHH	57.51	-
55	Acetylation	EDCVAFGKGENAKKY HHHHHCCCCCCHHHH	57.51	25825284
55	2-Hydroxyisobutyrylation	EDCVAFGKGENAKKY HHHHHCCCCCCHHHH	57.51	-
55	Malonylation	EDCVAFGKGENAKKY HHHHHCCCCCCHHHH	57.51	26320211
60	Ubiquitination	FGKGENAKKYLRTDD CCCCCCHHHHCCCCH	54.24	-
60	Acetylation	FGKGENAKKYLRTDD CCCCCCHHHHCCCCH	54.24	-
60	Malonylation	FGKGENAKKYLRTDD CCCCCCHHHHCCCCH	54.24	26320211
62	Phosphorylation	KGENAKKYLRTDDRV CCCCHHHHCCCCHHH	10.74	29214152
65	Phosphorylation	NAKKYLRTDDRVERV CHHHHCCCCHHHHHH	39.39	29214152
121	Phosphorylation	RIYHTIAYLTPLPQP HHHHHHHHHCCCCCC	13.78	21253578
123	Phosphorylation	YHTIAYLTPLPQPNR HHHHHHHCCCCCCCC	15.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGST1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGST1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGST1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LTC4S_HUMAN	LTC4S	physical	8954909

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00143: Glutathione