HEBP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEBP1_HUMAN
• UniProt AC: Q9NRV9
• Protein Name: Heme-binding protein 1
• Gene Name: HEBP1
• Organism: Homo sapiens (Human).
• Sequence Length: 189
• Subcellular Localization: Cytoplasm .
• Protein Description: May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities..
• Protein Sequence: MLGMIKNSLFGSVETWPWQVLSKGDKEEVAYEERACEGGKFATVEVTDKPVDEALREAMPKVAKYAGGTNDKGIGMGMTVPISFAVFPNEDGSLQKKLKVWFRIPNQFQSDPPAPSDKSVKIEEREGITVYSMQFGGYAKEADYVAQATRLRAALEGTATYRGDIYFCTGYDPPMKPYGRRNEIWLLKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	IKNSLFGSVETWPWQ CCCCCCCCCCCCCCE	14.94	28348404
15	Phosphorylation	SLFGSVETWPWQVLS CCCCCCCCCCCEEEE	34.37	24719451
40	2-Hydroxyisobutyrylation	ERACEGGKFATVEVT EHHHCCCCEEEEEEC	42.56	-
40	Acetylation	ERACEGGKFATVEVT EHHHCCCCEEEEEEC	42.56	26051181
40	Ubiquitination	ERACEGGKFATVEVT EHHHCCCCEEEEEEC	42.56	-
49	Ubiquitination	ATVEVTDKPVDEALR EEEEECCCCHHHHHH	37.26	21906983
64	Ubiquitination	EAMPKVAKYAGGTND HHCHHHHHHCCCCCC	38.32	-
96	Ubiquitination	NEDGSLQKKLKVWFR CCCCCHHEEEEEEEE	66.42	-
110	Phosphorylation	RIPNQFQSDPPAPSD ECCCCCCCCCCCCCC	54.06	27251275
118	Ubiquitination	DPPAPSDKSVKIEER CCCCCCCCCCEEEEE	62.58	21906983
121	Acetylation	APSDKSVKIEEREGI CCCCCCCEEEEECCE	52.03	7671075
121	Ubiquitination	APSDKSVKIEEREGI CCCCCCCEEEEECCE	52.03	-
129	Phosphorylation	IEEREGITVYSMQFG EEEECCEEEEEEEEC	25.01	21406692
131	Phosphorylation	EREGITVYSMQFGGY EECCEEEEEEEECCH	6.97	21406692
132	Phosphorylation	REGITVYSMQFGGYA ECCEEEEEEEECCHH	11.19	21406692
138	Phosphorylation	YSMQFGGYAKEADYV EEEEECCHHHHHHHH	18.19	21406692
144	Phosphorylation	GYAKEADYVAQATRL CHHHHHHHHHHHHHH	12.53	22817900
175	Sulfoxidation	CTGYDPPMKPYGRRN EECCCCCCCCCCCCC	9.21	30846556

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEBP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEBP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEBP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COTL1_HUMAN	COTL1	physical	26344197
PCBP1_HUMAN	PCBP1	physical	26344197
S10A6_HUMAN	S100A6	physical	26344197
SNX3_HUMAN	SNX3	physical	26344197
UB2L3_HUMAN	UBE2L3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.