PTPM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTPM1_HUMAN
• UniProt AC: Q8WUK0
• Protein Name: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
• Gene Name: PTPMT1
• Organism: Homo sapiens (Human).
• Sequence Length: 201
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity. [PubMed: 24709986]
• Protein Sequence: MAATALLEAGLARVLFYPTLLYTLFRGKVPGRAHRDWYHRIDPTVLLGALPLRSLTRQLVQDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLKEFHKQITARATKDGTFVISKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	LFYPTLLYTLFRGKV HHHHHHHHHHHCCCC	12.43	24719451
23	Phosphorylation	FYPTLLYTLFRGKVP HHHHHHHHHHCCCCC	21.27	24719451
38	Phosphorylation	GRAHRDWYHRIDPTV CCCCCCHHHCCCHHH	5.87	24719451
75	Phosphorylation	VITMNEEYETRFLCN EEECCHHHCEEEECC	19.20	-
88 (in isoform 3)	Phosphorylation	-	36.67	-
88	Acetylation	CNSSQEWKRLGVEQL CCCCHHHHHHCCCEE	36.67	26051181
88	Succinylation	CNSSQEWKRLGVEQL CCCCHHHHHHCCCEE	36.67	27452117
93 (in isoform 3)	Phosphorylation	-	41.94	-
164	Ubiquitination	EAVRAIAKIRSYIHI HHHHHHHHHHHHHEE	32.32	-
180	Ubiquitination	PGQLDVLKEFHKQIT CCCHHHHHHHHHHHH	59.17	21963094
184	Ubiquitination	DVLKEFHKQITARAT HHHHHHHHHHHHEEC	49.03	22817900
192	Ubiquitination	QITARATKDGTFVIS HHHHEECCCCCEEEE	53.85	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTPM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTPM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTPM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C40_HUMAN	KRT40	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
MDFI_HUMAN	MDFI	physical	21516116
RGS20_HUMAN	RGS20	physical	21516116
PTPM1_HUMAN	PTPMT1	physical	27499296
CLPB_HUMAN	CLPB	physical	27499296
CLPX_HUMAN	CLPX	physical	27499296
STML2_HUMAN	STOML2	physical	27499296
TIM44_HUMAN	TIMM44	physical	27499296
AFG32_HUMAN	AFG3L2	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
GLSK_HUMAN	GLS	physical	27499296
OXA1L_HUMAN	OXA1L	physical	27499296
MIC60_HUMAN	IMMT	physical	27499296
USMG5_HUMAN	USMG5	physical	27499296
PAK5_HUMAN	PAK7	physical	27499296
ATP5H_HUMAN	ATP5H	physical	27499296
TXTP_HUMAN	SLC25A1	physical	27499296
MOT1_HUMAN	SLC16A1	physical	27499296
CYC_HUMAN	CYCS	physical	27499296
SNP29_HUMAN	SNAP29	physical	27499296
ATPO_HUMAN	ATP5O	physical	27499296
ATP5E_HUMAN	ATP5E	physical	27499296
TIM50_HUMAN	TIMM50	physical	27499296
COQ5_HUMAN	COQ5	physical	27499296
CISD1_HUMAN	CISD1	physical	27499296
NDUS3_HUMAN	NDUFS3	physical	27499296
QCR7_HUMAN	UQCRB	physical	27499296
AT5F1_HUMAN	ATP5F1	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
ATD3A_HUMAN	ATAD3A	physical	27499296
CX7A2_HUMAN	COX7A2	physical	27499296
NDUF2_HUMAN	NDUFAF2	physical	27499296
UCRI_HUMAN	UQCRFS1	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
CT024_HUMAN	C20orf24	physical	27499296
ACSL4_HUMAN	ACSL4	physical	27499296
SCOT1_HUMAN	OXCT1	physical	27499296
SFXN1_HUMAN	SFXN1	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
COQ9_HUMAN	COQ9	physical	27499296
LETM1_HUMAN	LETM1	physical	27499296
COQ7_HUMAN	COQ7	physical	27499296
HINT3_HUMAN	HINT3	physical	27499296
ATP5J_HUMAN	ATP5J	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
CPT2_HUMAN	CPT2	physical	27499296
NDUA8_HUMAN	NDUFA8	physical	27499296
QCR2_HUMAN	UQCRC2	physical	27499296
COX5A_HUMAN	COX5A	physical	27499296
NIPS1_HUMAN	NIPSNAP1	physical	27499296
MTCH2_HUMAN	MTCH2	physical	27499296
TIM16_HUMAN	PAM16	physical	27499296
MPCP_HUMAN	SLC25A3	physical	27499296
AT2A2_HUMAN	ATP2A2	physical	27880917
FKBP8_HUMAN	FKBP8	physical	27880917
IPO9_HUMAN	IPO9	physical	27880917
NU133_HUMAN	NUP133	physical	27880917
XPO4_HUMAN	XPO4	physical	27880917

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.