CISD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CISD1_HUMAN
• UniProt AC: Q9NZ45
• Protein Name: CDGSH iron-sulfur domain-containing protein 1
• Gene Name: CISD1
• Organism: Homo sapiens (Human).
• Sequence Length: 108
• Subcellular Localization: Mitochondrion outer membrane ; Single-pass type III membrane protein .
• Protein Description: Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions..
• Protein Sequence: MSLTSSSSVRVEWIAAVTIAAGTAAIGYLAYKRFYVKDHRNKAMINLHIQKDNPKIVHAFDMEDLGDKAVYCRCWRSKKFPFCDGAHTKHNEETGDNVGPLIIKKKET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSLTSSSSV ------CCCCCCCCE	40.11	22814378
2	Phosphorylation	------MSLTSSSSV ------CCCCCCCCE	40.11	21406692
4	Phosphorylation	----MSLTSSSSVRV ----CCCCCCCCEEH	21.18	21406692
5	Phosphorylation	---MSLTSSSSVRVE ---CCCCCCCCEEHE	33.25	21406692
6	Phosphorylation	--MSLTSSSSVRVEW --CCCCCCCCEEHEE	22.77	21406692
7	Phosphorylation	-MSLTSSSSVRVEWI -CCCCCCCCEEHEEE	32.40	21406692
8	Phosphorylation	MSLTSSSSVRVEWIA CCCCCCCCEEHEEEE	18.85	21406692
18	Phosphorylation	VEWIAAVTIAAGTAA HEEEEEHHHHHHHHH	10.52	26552605
23	Phosphorylation	AVTIAAGTAAIGYLA EHHHHHHHHHHHHHH	14.27	26552605
28	Phosphorylation	AGTAAIGYLAYKRFY HHHHHHHHHHHHEEE	5.09	26552605
31	Phosphorylation	AAIGYLAYKRFYVKD HHHHHHHHHEEEEEC	10.49	27251275
35	Phosphorylation	YLAYKRFYVKDHRNK HHHHHEEEEECCCCC	15.60	27251275
37	Ubiquitination	AYKRFYVKDHRNKAM HHHEEEEECCCCCEE	36.12	-
37	Acetylation	AYKRFYVKDHRNKAM HHHEEEEECCCCCEE	36.12	27452117
42	Ubiquitination	YVKDHRNKAMINLHI EEECCCCCEEEEEEE	39.01	25621951
51	Ubiquitination	MINLHIQKDNPKIVH EEEEEECCCCCCEEE	59.89	-
51	Acetylation	MINLHIQKDNPKIVH EEEEEECCCCCCEEE	59.89	8242911
55	Ubiquitination	HIQKDNPKIVHAFDM EECCCCCCEEEEEEH	64.71	25621951
55	Acetylation	HIQKDNPKIVHAFDM EECCCCCCEEEEEEH	64.71	23954790
55	Succinylation	HIQKDNPKIVHAFDM EECCCCCCEEEEEEH	64.71	27452117
62	Sulfoxidation	KIVHAFDMEDLGDKA CEEEEEEHHHHCCCE	3.31	21406390
68	Malonylation	DMEDLGDKAVYCRCW EHHHHCCCEEEEEEC	37.64	26320211
68	Ubiquitination	DMEDLGDKAVYCRCW EHHHHCCCEEEEEEC	37.64	25621951
68	Succinylation	DMEDLGDKAVYCRCW EHHHHCCCEEEEEEC	37.64	27452117
68	Acetylation	DMEDLGDKAVYCRCW EHHHHCCCEEEEEEC	37.64	23954790
71	Phosphorylation	DLGDKAVYCRCWRSK HHCCCEEEEEECCCC	4.50	29496907
77	Phosphorylation	VYCRCWRSKKFPFCD EEEEECCCCCCCCCC	18.72	29214152
78	Ubiquitination	YCRCWRSKKFPFCDG EEEECCCCCCCCCCC	50.27	25621951
79	Acetylation	CRCWRSKKFPFCDGA EEECCCCCCCCCCCC	60.56	27452117
79	Ubiquitination	CRCWRSKKFPFCDGA EEECCCCCCCCCCCC	60.56	25621951
88	Phosphorylation	PFCDGAHTKHNEETG CCCCCCCCCCCCCCC	33.20	26437602
89	Acetylation	FCDGAHTKHNEETGD CCCCCCCCCCCCCCC	34.27	27452117
89	Ubiquitination	FCDGAHTKHNEETGD CCCCCCCCCCCCCCC	34.27	25621951
104	Ubiquitination	NVGPLIIKKKET--- CCCCEEEEECCC---	51.29	25621951
104	Acetylation	NVGPLIIKKKET--- CCCCEEEEECCC---	51.29	23954790
105	Ubiquitination	VGPLIIKKKET---- CCCEEEEECCC----	45.49	25621951
106	Ubiquitination	GPLIIKKKET----- CCEEEEECCC-----	62.68	25621951

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:31110043

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CISD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CISD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTX1_HUMAN	MTX1	physical	22939629
TOM7_HUMAN	TOMM7	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
VATC1_HUMAN	ATP6V1C1	physical	22939629
BAP31_HUMAN	BCAP31	physical	26344197
CLH1_HUMAN	CLTC	physical	26344197
COX41_HUMAN	COX4I1	physical	26344197
NDUAC_HUMAN	NDUFA12	physical	26344197
NDUA2_HUMAN	NDUFA2	physical	26344197
PPIB_HUMAN	PPIB	physical	26344197
STX12_HUMAN	STX12	physical	26344197
STX7_HUMAN	STX7	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.