HINT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HINT3_HUMAN
• UniProt AC: Q9NQE9
• Protein Name: Histidine triad nucleotide-binding protein 3
• Gene Name: HINT3
• Organism: Homo sapiens (Human).
• Sequence Length: 182
• Subcellular Localization: Cytoplasm . Nucleus . Localized as aggregates in the cytoplasm and the nucleus.
• Protein Description: Hydrolyzes phosphoramidate and acyl-adenylate substrates..
• Protein Sequence: MAEEQVNRSAGLAPDCEASATAETTVSSVGTCEAAGKSPEPKDYDSTCVFCRIAGRQDPGTELLHCENEDLICFKDIKPAATHHYLVVPKKHIGNCRTLRKDQVELVENMVTVGKTILERNNFTDFTNVRMGFHMPPFCSISHLHLHVLAPVDQLGFLSKLVYRVNSYWFITADHLIEKLRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEEQVNRS ------CCHHHHHHH	29.09	22814378
27	Phosphorylation	ATAETTVSSVGTCEA CCEEEEECCCCCHHH	19.74	25627689
28	Phosphorylation	TAETTVSSVGTCEAA CEEEEECCCCCHHHC	21.89	25159151
31	Phosphorylation	TTVSSVGTCEAAGKS EEECCCCCHHHCCCC	12.67	21712546
38	Phosphorylation	TCEAAGKSPEPKDYD CHHHCCCCCCCCCCC	33.31	18669648
42	Ubiquitination	AGKSPEPKDYDSTCV CCCCCCCCCCCCCEE	68.22	29967540
75	Ubiquitination	NEDLICFKDIKPAAT CCCEEEEECCCCCCC	54.88	22817900
78	Ubiquitination	LICFKDIKPAATHHY EEEEECCCCCCCCEE	38.44	22817900
90	Ubiquitination	HHYLVVPKKHIGNCR CEEEEEECHHCCCCC	45.43	29967540
91	Ubiquitination	HYLVVPKKHIGNCRT EEEEEECHHCCCCCC	34.09	29967540
101	Ubiquitination	GNCRTLRKDQVELVE CCCCCCCHHHHHHHH	56.47	29967540
115	Sumoylation	ENMVTVGKTILERNN HHHHHHCHHHHHHCC	28.23	-
115	Ubiquitination	ENMVTVGKTILERNN HHHHHHCHHHHHHCC	28.23	21906983
115	Sumoylation	ENMVTVGKTILERNN HHHHHHCHHHHHHCC	28.23	-
179	Ubiquitination	TADHLIEKLRT---- EHHHHHHHHHC----	35.95	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HINT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HINT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HINT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330