TMM65_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMM65_HUMAN
• UniProt AC: Q6PI78
• Protein Name: Transmembrane protein 65
• Gene Name: TMEM65
• Organism: Homo sapiens (Human).
• Sequence Length: 240
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Mitochondrion inner membrane ; Multi-pass membrane protein . Localizes at the intercalated disk in the ventricular tissue (PubMed:26403541).
• Protein Description: May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contributes to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance. [PubMed: 28295037]
• Protein Sequence: MSRLLPLLRSRTARSLRPGPAAAAAPRPPSWCCCGRGLLALAPPGGLPGGPRRLGTHPKKEPMEALNTAQGARDFIYSLHSTERSCLLKELHRFESIAIAQEKLEAPPPTPGQLRYVFIHNAIPFIGFGFLDNAIMIVAGTHIEMSIGIILGISTMAAAALGNLVSDLAGLGLAGYVEALASRLGLSIPDLTPKQVDMWQTRLSTHLGKAVGVTIGCILGMFPLIFFGGGEEDEKLETKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	AAAPRPPSWCCCGRG HCCCCCCCEEECCCC	35.11	18767875
110	Phosphorylation	KLEAPPPTPGQLRYV HHCCCCCCCCCEEEE	45.91	27050516
187	Phosphorylation	LASRLGLSIPDLTPK HHHHHCCCCCCCCHH	30.21	30177828
192	Phosphorylation	GLSIPDLTPKQVDMW CCCCCCCCHHHHHHH	35.50	30177828
194	Ubiquitination	SIPDLTPKQVDMWQT CCCCCCHHHHHHHHH	58.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMM65_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMM65_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMM65_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TX1B3_HUMAN	TAX1BP3	physical	22939629
MPZL1_HUMAN	MPZL1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.