TX1B3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TX1B3_HUMAN
• UniProt AC: O14907
• Protein Name: Tax1-binding protein 3
• Gene Name: TAX1BP3 {ECO:0000312|HGNC:HGNC:30684}
• Organism: Homo sapiens (Human).
• Sequence Length: 124
• Subcellular Localization: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Recruited to the cell membrane by interaction with membrane proteins.
• Protein Description: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6..
• Protein Sequence: MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYIPGQPV ------CCCCCCCCE	31.59	30576142
2	Acetylation	------MSYIPGQPV ------CCCCCCCCE	31.59	22223895
3	Phosphorylation	-----MSYIPGQPVT -----CCCCCCCCEE	15.16	25394399
10	Phosphorylation	YIPGQPVTAVVQRVE CCCCCCEEEEEEEEE	22.03	24043423
32	Phosphorylation	ENLILGFSIGGGIDQ CCEEEEEEECCCCCC	20.65	28348404
42	Phosphorylation	GGIDQDPSQNPFSED CCCCCCCCCCCCCCC	51.37	28348404
53	2-Hydroxyisobutyrylation	FSEDKTDKGIYVTRV CCCCCCCCCEEEEEE	53.06	-
53	Ubiquitination	FSEDKTDKGIYVTRV CCCCCCCCCEEEEEE	53.06	-
56	Phosphorylation	DKTDKGIYVTRVSEG CCCCCCEEEEEECCC	12.39	30576142
58	Phosphorylation	TDKGIYVTRVSEGGP CCCCEEEEEECCCCC	14.37	22617229
61	Phosphorylation	GIYVTRVSEGGPAEI CEEEEEECCCCCCEE	27.51	30266825
86	Phosphorylation	QVNGWDMTMVTHDQA EECCCEEEEECHHHH	13.15	26552605
89	Phosphorylation	GWDMTMVTHDQARKR CCEEEEECHHHHHHH	14.65	26552605
110	Phosphorylation	EVVRLLVTRQSLQKA HHHHHHHHHHHHHHH	23.98	22496350
113	Phosphorylation	RLLVTRQSLQKAVQQ HHHHHHHHHHHHHHH	29.49	29978859
116	Ubiquitination	VTRQSLQKAVQQSML HHHHHHHHHHHHHHC	56.68	-
121	Phosphorylation	LQKAVQQSMLS---- HHHHHHHHHCC----	12.47	20068231
124	Phosphorylation	AVQQSMLS------- HHHHHHCC-------	29.54	22496350

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TX1B3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TX1B3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TX1B3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_HUMAN	CTNNB1	physical	18835279
CK5P3_HUMAN	CDK5RAP3	physical	23028987
UB2D2_HUMAN	UBE2D2	physical	22939629
VAMP2_HUMAN	VAMP2	physical	22939629
DTX1_HUMAN	DTX1	physical	23395680
STAU1_HUMAN	STAU1	physical	23395680
RN183_HUMAN	RNF183	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND MASSSPECTROMETRY.
PubMed: 18669648