TRIA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRIA1_HUMAN
• UniProt AC: O43715
• Protein Name: TP53-regulated inhibitor of apoptosis 1
• Gene Name: TRIAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 76
• Subcellular Localization: Cytoplasm, perinuclear region . Mitochondrion . Mitochondrion intermembrane space .
• Protein Description: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. [PubMed: 23931759 Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo)]
• Protein Sequence: MNSVGEACTDMKREYDQCFNRWFAEKFLKGDSSGDPCTDLFKRYQQCVQKAIKEKEIPIEGLEFMGHGKEKPENSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNSVGEAC -------CCCHHHHH	8.33	22814378
9	Phosphorylation	NSVGEACTDMKREYD CCHHHHHHHHHHHHH	46.29	24043423
12	Acetylation	GEACTDMKREYDQCF HHHHHHHHHHHHHHH	44.91	27452117
21	Methylation	EYDQCFNRWFAEKFL HHHHHHHHHHHHHHH	15.05	115918945
26	Ubiquitination	FNRWFAEKFLKGDSS HHHHHHHHHHCCCCC	53.20	22817900
29	Ubiquitination	WFAEKFLKGDSSGDP HHHHHHHCCCCCCCC	64.90	22817900
32	Phosphorylation	EKFLKGDSSGDPCTD HHHHCCCCCCCCHHH	44.91	25627689
42	Ubiquitination	DPCTDLFKRYQQCVQ CCHHHHHHHHHHHHH	58.45	29967540
42	Acetylation	DPCTDLFKRYQQCVQ CCHHHHHHHHHHHHH	58.45	26822725
50	Ubiquitination	RYQQCVQKAIKEKEI HHHHHHHHHHHHCCC	31.51	29967540
50	Acetylation	RYQQCVQKAIKEKEI HHHHHHHHHHHHCCC	31.51	26051181
55	Ubiquitination	VQKAIKEKEIPIEGL HHHHHHHCCCCCCCC	56.81	29967540
55	Acetylation	VQKAIKEKEIPIEGL HHHHHHHCCCCCCCC	56.81	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRIA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRIA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRIA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP74_HUMAN	HSPA4	physical	15735003
APAF_HUMAN	APAF1	physical	15735003
PRLD1_HUMAN	PRELID1	physical	28514442
PLD3B_HUMAN	SLMO2	physical	28514442
PLD3A_HUMAN	SLMO1	physical	28514442
IGJ_HUMAN	IGJ	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330