dbPTM

PPOX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PPOX_HUMAN
UniProt AC	P50336
Protein Name	Protoporphyrinogen oxidase
Gene Name	PPOX
Organism	Homo sapiens (Human).
Sequence Length	477
Subcellular Localization	Mitochondrion inner membrane Peripheral membrane protein Intermembrane side.
Protein Description	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX..
Protein Sequence	MGRTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRGPNGAIFELGPRGIRPAGALGARTLLLVSELGLDSEVLPVRGDHPAAQNRFLYVGGALHALPTGLRGLLRPSPPFSKPLFWAGLRELTKPRGKEPDETVHSFAQRRLGPEVASLAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAERWSQWSLRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLGGSWLQTLEASGCVLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAAVSVLGTEPNS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGRTVVVLGGG ----CCCEEEEECCC	16.36	24719451
19	Phosphorylation	ISGLAASYHLSRAPC HHHHHHHHHHHCCCC	11.31	24719451
123	Phosphorylation	LRPSPPFSKPLFWAG CCCCCCCCCCCHHHH	38.85	24719451
179	Phosphorylation	AGNSRELSIRSCFPS CCCCCCEEHHHHCHH	15.94	24719451
228	Phosphorylation	AERWSQWSLRGGLEM HHHHHHHHHHHHHHH	10.68	24719451
242	Phosphorylation	MLPQALETHLTSRGV HHHHHHHHHHHHCCC	24.04	24275569
473	Phosphorylation	AAVSVLGTEPNS--- EEHHHHCCCCCC---	44.07	-
477	Phosphorylation	VLGTEPNS------- HHCCCCCC-------	52.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PPOX_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PPOX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PPOX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
HAP1_HUMAN	HAP1	physical	16169070
MIC60_HUMAN	IMMT	physical	16169070

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PPOX_HUMAN

Related Literatures of Post-Translational Modification