COQ3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COQ3_HUMAN
• UniProt AC: Q9NZJ6
• Protein Name: Ubiquinone biosynthesis O-methyltransferase, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03190}
• Gene Name: COQ3 {ECO:0000255|HAMAP-Rule:MF_03190}
• Organism: Homo sapiens (Human).
• Sequence Length: 369
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway..
• Protein Sequence: MWSGRKLGSSGGWFLRVLGPGGCNTKAARPLISSAVYVKNQLSGTLQIKPGVFNEYRTIWFKSYRTIFSCLNRIKSFRYPWARLYSTSQTTVDSGEVKTFLALAHKWWDEQGVYAPLHSMNDLRVPFIRDNLLKTIPNHQPGKPLLGMKILDVGCGGGLLTEPLGRLGASVIGIDPVDENIKTAQCHKSFDPVLDKRIEYRVCSLEEIVEETAETFDAVVASEVVEHVIDLETFLQCCCQVLKPGGSLFITTINKTQLSYALGIVFSEQIASIVPKGTHTWEKFVSPETLESILESNGLSVQTVVGMLYNPFSGYWHWSENTSLNYAAYAVKSRVQEHPASAEFVLKGETEELQANACTNPAVHEKLKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	VKNQLSGTLQIKPGV EECCCCCEEEECCCC	16.47	17081983
69	Phosphorylation	KSYRTIFSCLNRIKS HHHHHHHHHHHHHHH	17.53	30631047
143	Acetylation	IPNHQPGKPLLGMKI CCCCCCCCCCCCCEE	38.89	-
149	Acetylation	GKPLLGMKILDVGCG CCCCCCCEEEEECCC	38.02	-
155	Glutathionylation	MKILDVGCGGGLLTE CEEEEECCCCCHHHC	4.62	22555962
182	Ubiquitination	DPVDENIKTAQCHKS CCCCCCCCHHHCCCC	49.76	29967540
188	Ubiquitination	IKTAQCHKSFDPVLD CCHHHCCCCCCHHHH	61.52	29967540
196	Acetylation	SFDPVLDKRIEYRVC CCCHHHHHHEEEEEC	51.63	2380491
196	Ubiquitination	SFDPVLDKRIEYRVC CCCHHHHHHEEEEEC	51.63	-
196	2-Hydroxyisobutyrylation	SFDPVLDKRIEYRVC CCCHHHHHHEEEEEC	51.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COQ3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COQ3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COQ3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS28_HUMAN	VPS28	physical	26186194
NOVA1_HUMAN	NOVA1	physical	26344197
COQ6_HUMAN	COQ6	physical	27499296
COQ3_HUMAN	COQ3	physical	27499296
NFS1_HUMAN	NFS1	physical	27499296
COQ9_HUMAN	COQ9	physical	27499296
COQ5_HUMAN	COQ5	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
COQ7_HUMAN	COQ7	physical	27499296
COQ8B_HUMAN	ADCK4	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
VPS28_HUMAN	VPS28	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.