| UniProt ID | COQ8B_HUMAN | |
|---|---|---|
| UniProt AC | Q96D53 | |
| Protein Name | Atypical kinase COQ8B, mitochondrial {ECO:0000305} | |
| Gene Name | COQ8B {ECO:0000312|HGNC:HGNC:19041} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 544 | |
| Subcellular Localization |
Mitochondrion membrane Single-pass membrane protein . Cytoplasm, cytosol . Cell membrane . |
|
| Protein Description | Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. [PubMed: 24270420 Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration] | |
| Protein Sequence | MWLKVGGLLRGTGGQLGQTVGWPCGALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIRRAREARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEMAKKSMPGGRLQSEGGSGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQHIFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLTGFETKAFSDAHVEAVMILGEPFATQGPYDFGSGETARRIQDLIPVLLRHRLCPPPEETYALHRKLAGAFLACAHLRAHIACRDLFQDTYHRYWASRQPDAATAGSLPTKGDSWVDPS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 79 | Phosphorylation | RPQLSDRSRERKVPA CCCCCHHHHCCCCCH | 17081983 | ||
| 383 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 424 | Ubiquitination | LQKSRDLKFLTGFET EEECCCCCHHHCCCC | 21890473 | ||
| 424 (in isoform 1) | Ubiquitination | - | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COQ8B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COQ8B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COQ8B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| COQ8B_HUMAN | ADCK4 | physical | 27499296 | |
| COQ5_HUMAN | COQ5 | physical | 27499296 | |
| STML2_HUMAN | STOML2 | physical | 27499296 | |
| MPPA_HUMAN | PMPCA | physical | 27499296 | |
| MPPB_HUMAN | PMPCB | physical | 27499296 | |
| COQ9_HUMAN | COQ9 | physical | 27499296 | |
| PREP_HUMAN | PITRM1 | physical | 27499296 | |
| COQ6_HUMAN | COQ6 | physical | 27499296 | |
| COQ8A_HUMAN | ADCK3 | physical | 27499296 | |
| COQ7_HUMAN | COQ7 | physical | 27499296 | |
| CHCH2_HUMAN | CHCHD2 | physical | 27499296 | |
| CLPB_HUMAN | CLPB | physical | 27499296 | |
| ATPO_HUMAN | ATP5O | physical | 27499296 | |
| ATP5H_HUMAN | ATP5H | physical | 27499296 | |
| AT5F1_HUMAN | ATP5F1 | physical | 27499296 | |
| PDIP2_HUMAN | POLDIP2 | physical | 27499296 | |
| ATP5E_HUMAN | ATP5E | physical | 27499296 | |
| COQ3_HUMAN | COQ3 | physical | 27499296 | |
| ERAL1_HUMAN | ERAL1 | physical | 27499296 | |
| GOLP3_HUMAN | GOLPH3 | physical | 27499296 | |
| ATPG_HUMAN | ATP5C1 | physical | 27499296 | |
| C1QBP_HUMAN | C1QBP | physical | 27499296 | |
| TIM44_HUMAN | TIMM44 | physical | 27499296 | |
| TIM50_HUMAN | TIMM50 | physical | 27499296 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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