| UniProt ID | PPM1K_HUMAN | |
|---|---|---|
| UniProt AC | Q8N3J5 | |
| Protein Name | Protein phosphatase 1K, mitochondrial | |
| Gene Name | PPM1K | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 372 | |
| Subcellular Localization | Mitochondrion matrix . | |
| Protein Description | Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.. | |
| Protein Sequence | MSTAALITLVRSGGNQVRRRVLLSSRLLQDDRRVTPTCHSSTSEPRCSRFDPDGSGSPATWDNFGIWDNRIDEPILLPPSIKYGKPIPKISLENVGCASQIGKRKENEDRFDFAQLTDEVLYFAVYDGHGGPAAADFCHTHMEKCIMDLLPKEKNLETLLTLAFLEIDKAFSSHARLSADATLLTSGTTATVALLRDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSLGQPHVNGRLAMTRSIGDLDLKTSGVIAEPETKRIKLHHADDSFLVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAVVVPFGAWGKYKNSEINFSFSRSFASSGRWA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Phosphorylation | VRRRVLLSSRLLQDD HHHHHHHHCHHHCCC | 14.84 | 24719451 | |
| 25 | Phosphorylation | RRRVLLSSRLLQDDR HHHHHHHCHHHCCCC | 27.24 | 24719451 | |
| 103 | Ubiquitination | GCASQIGKRKENEDR CCHHHCCCCCCCCCC | 63.02 | 29967540 | |
| 216 (in isoform 2) | Phosphorylation | - | 71.00 | 22985185 | |
| 248 | Phosphorylation | GGFVAWNSLGQPHVN CCEEEECCCCCCCCC | 24.15 | 28450419 | |
| 263 | Phosphorylation | GRLAMTRSIGDLDLK CEEEECEEECCCCCC | 23.04 | 22210691 | |
| 270 | Ubiquitination | SIGDLDLKTSGVIAE EECCCCCCCCCEECC | 40.07 | 29967540 | |
| 271 | Phosphorylation | IGDLDLKTSGVIAEP ECCCCCCCCCEECCC | 37.70 | 22210691 | |
| 281 | Ubiquitination | VIAEPETKRIKLHHA EECCCCCCEEEEECC | 50.92 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PPM1K_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PPM1K_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PPM1K_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ODB2_HUMAN | DBT | physical | 26186194 | |
| ODBB_HUMAN | BCKDHB | physical | 26186194 | |
| ODBA_HUMAN | BCKDHA | physical | 26186194 | |
| BIRC2_HUMAN | BIRC2 | physical | 21516116 | |
| PPM1K_HUMAN | PPM1K | physical | 27499296 | |
| NDKB_HUMAN | NME2 | physical | 27499296 | |
| ODBB_HUMAN | BCKDHB | physical | 27499296 | |
| ODB2_HUMAN | DBT | physical | 27499296 | |
| ODBA_HUMAN | BCKDHA | physical | 27499296 | |
| IDE_HUMAN | IDE | physical | 27499296 | |
| MPPB_HUMAN | PMPCB | physical | 27499296 | |
| MPPA_HUMAN | PMPCA | physical | 27499296 | |
| BCKD_HUMAN | BCKDK | physical | 27499296 | |
| RM13_HUMAN | MRPL13 | physical | 27499296 | |
| PREP_HUMAN | PITRM1 | physical | 27499296 | |
| C1QBP_HUMAN | C1QBP | physical | 27499296 | |
| ODBA_HUMAN | BCKDHA | physical | 27880917 | |
| ODBB_HUMAN | BCKDHB | physical | 27880917 | |
| ODB2_HUMAN | DBT | physical | 27880917 | |
| ENAH_HUMAN | ENAH | physical | 27880917 | |
| JIP4_HUMAN | SPAG9 | physical | 27880917 | |
| ODB2_HUMAN | DBT | physical | 28514442 | |
| ODBB_HUMAN | BCKDHB | physical | 28514442 | |
| ODBA_HUMAN | BCKDHA | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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