PX11B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PX11B_HUMAN
• UniProt AC: O96011
• Protein Name: Peroxisomal membrane protein 11B
• Gene Name: PEX11B
• Organism: Homo sapiens (Human).
• Sequence Length: 259
• Subcellular Localization: Peroxisome membrane ; Single-pass membrane protein .
• Protein Description: Involved in peroxisomal proliferation. [PubMed: 9792670 May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane]
• Protein Sequence: MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLRLGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPGGGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGLVSSILSILTLIYPWLRLKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	WVRFSAQSQARERLC CHHHHHHHHHHHHHH	26.06	28348404
26	Phosphorylation	RAAQYACSLLGHALQ HHHHHHHHHHHHHHH	20.61	23898821
29	Ubiquitination	QYACSLLGHALQRHG HHHHHHHHHHHHHCC	14.87	19608861
29	Acetylation	QYACSLLGHALQRHG HHHHHHHHHHHHHCC	14.87	19608861
38	Phosphorylation	ALQRHGASPELQKQI HHHHCCCCHHHHHHH	24.41	25849741
43	Ubiquitination	GASPELQKQIRQLES CCCHHHHHHHHHHHH	61.39	21906983
43	Acetylation	GASPELQKQIRQLES CCCHHHHHHHHHHHH	61.39	19608861
53	Phosphorylation	RQLESHLSLGRKLLR HHHHHHHHHHHHHHH	24.29	23312004
64	Phosphorylation	KLLRLGNSADALESA HHHHCCCCHHHHHHH	26.23	30622161
72	Ubiquitination	ADALESAKRAVHLSD HHHHHHHHHHHHHHH	50.60	21906983
72	Acetylation	ADALESAKRAVHLSD HHHHHHHHHHHHHHH	50.60	30591217
96	Phosphorylation	SHLNRALYFACDNVL HHHHHHHHHHHCCCH	6.53	-
107	Ubiquitination	DNVLWAGKSGLAPRV CCCHHCCCCCCCCCC	33.34	21906983
126	Phosphorylation	WAQRSFRYYLFSLIM HHHHHHHHHHHHHHH	11.51	22817900
136	Phosphorylation	FSLIMNLSRDAYEIR HHHHHHHCCCHHHHH	24.10	19413330
158	Ubiquitination	SACSRRLKGSGGGVP HHHHHHHCCCCCCCC	49.58	21906983
160	Phosphorylation	CSRRLKGSGGGVPGG HHHHHCCCCCCCCCC	32.45	25159151
168	Phosphorylation	GGGVPGGSETGGLGG CCCCCCCCCCCCCCC	37.59	28857561
170	Phosphorylation	GVPGGSETGGLGGPG CCCCCCCCCCCCCCC	37.94	23312004
224	Ubiquitination	DLFIPLDKLGLWRCG CCEECHHHHCCCCCC	52.73	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PX11B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PX11B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PX11B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNM1L_HUMAN	DNM1L	genetic	20826455
FIS1_HUMAN	FIS1	genetic	20826455
PX11B_HUMAN	PEX11B	physical	20826455
FIS1_HUMAN	FIS1	physical	20826455
PEX19_HUMAN	PEX19	physical	12096124

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614920: Peroxisome biogenesis disorder 14B (PBD14B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-43, AND MASS SPECTROMETRY.
PubMed: 19608861