AGK_HUMAN - dbPTM
AGK_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AGK_HUMAN
UniProt AC Q53H12
Protein Name Acylglycerol kinase, mitochondrial {ECO:0000303|PubMed:15939762}
Gene Name AGK {ECO:0000303|PubMed:15939762, ECO:0000312|HGNC:HGNC:21869}
Organism Homo sapiens (Human).
Sequence Length 422
Subcellular Localization Mitochondrion inner membrane
Peripheral membrane protein . Mitochondrion intermembrane space . Localizes in the mitochondrion intermembrane space, where it associates with the inner membrane (PubMed:28712724). It is unclear whether the N-terminal h
Protein Description Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. [PubMed: 15939762 Does not phosphorylate sphingosine]
Protein Sequence MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHVEGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSPTQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Ubiquitination--MTVFFKTLRNHWK
--CCEEHHHHHHHHC		34.8721890473
6 (in isoform 2)Ubiquitination-34.8721890473
6Acetylation--MTVFFKTLRNHWK
--CCEEHHHHHHHHC		34.8719608861
72GlutathionylationVFLNPAACKGKARTL
EEECHHHHCCHHHHH		6.9322555962
107 (in isoform 1)Ubiquitination-35.7521890473
107UbiquitinationTDYEGQAKKLLELME
ECCHHHHHHHHHHHH		35.7521906983
157PhosphorylationGFIPLGETSSLSHTL
EEEECCCCCCCCEEE		23.0927732954
158PhosphorylationFIPLGETSSLSHTLF
EEECCCCCCCCEEEE		25.6127732954
159PhosphorylationIPLGETSSLSHTLFA
EECCCCCCCCEEEEE		41.1127732954
161PhosphorylationLGETSSLSHTLFAES
CCCCCCCCEEEEECC		19.1727732954
163PhosphorylationETSSLSHTLFAESGN
CCCCCCEEEEECCCC		21.8627732954
168PhosphorylationSHTLFAESGNKVQHI
CEEEEECCCCEEEEE		44.2130108239
184UbiquitinationDATLAIVKGETVPLD
ECEEEEECCCEEECE		44.94-
196UbiquitinationPLDVLQIKGEKEQPV
ECEEEEECCCCCCCE		48.32-
199 (in isoform 1)Ubiquitination-71.0221890473
199UbiquitinationVLQIKGEKEQPVFAM
EEEECCCCCCCEEEE		71.0221906983
223 (in isoform 1)Ubiquitination-42.6721890473
223UbiquitinationDAGVKVSKYWYLGPL
HCCCEEEEEEEECCC		42.6721890473
226PhosphorylationVKVSKYWYLGPLKIK
CEEEEEEEECCCEEH		9.937178993
231AcetylationYWYLGPLKIKAAHFF
EEEECCCEEHHHHHH		45.347825219
233AcetylationYLGPLKIKAAHFFST
EECCCEEHHHHHHHH		37.627825229
285PhosphorylationRILRRLASYWAQPQD
HHHHHHHHHHCCCHH		26.2928122231
286PhosphorylationILRRLASYWAQPQDA
HHHHHHHHHCCCHHH		10.1228122231
295PhosphorylationAQPQDALSQEVSPEV
CCCHHHHCCCCCHHH		26.4728122231
325PhosphorylationRNNQLDPTSKEDFLN
CCCCCCCCCHHHHHH		52.6920068231
326PhosphorylationNNQLDPTSKEDFLNI
CCCCCCCCHHHHHHE		39.1620068231
327UbiquitinationNQLDPTSKEDFLNIC
CCCCCCCHHHHHHEE		64.872190698
327 (in isoform 1)Ubiquitination-64.8721890473
334GlutathionylationKEDFLNICIEPDTIS
HHHHHHEECCCCCCC		2.5422555962
347PhosphorylationISKGDFITIGSRKVR
CCCCCEEEECCEECC		21.1927080861
350PhosphorylationGDFITIGSRKVRNPK
CCEEEECCEECCCCC		25.6930266825
408GlutathionylationPRKLQFFCDPRKREQ
CCCCHHHCCHHHHHH		8.1122555962
418PhosphorylationRKREQMLTSPTQ---
HHHHHHCCCCCC---		27.5829759185
419PhosphorylationKREQMLTSPTQ----
HHHHHCCCCCC----		23.2220068231
421PhosphorylationEQMLTSPTQ------
HHHCCCCCC------		46.8320068231
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AGK_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AGK_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AGK_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
T10B_HUMANTIMM10Bphysical
28514442
TIM10_HUMANTIMM10physical
28514442
TIM29_HUMANC19orf52physical
28514442
AT12A_HUMANATP12Aphysical
28514442
RAB18_HUMANRAB18physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
212350Mitochondrial DNA depletion syndrome 10 (MTDPS10)
614691Cataract 38 (CTRCT38)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AGK_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-6, AND MASS SPECTROMETRY.

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