| UniProt ID | RDH14_HUMAN | |
|---|---|---|
| UniProt AC | Q9HBH5 | |
| Protein Name | Retinol dehydrogenase 14 | |
| Gene Name | RDH14 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 336 | |
| Subcellular Localization | ||
| Protein Description | Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected.. | |
| Protein Sequence | MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MAVATAAAVLAA ---CHHHHHHHHHHH | 15.38 | 28450419 | |
| 118 | Phosphorylation | VRELDLASLRSVRAF HHHHCHHHHHHHHHH | 31.45 | 24719451 | |
| 191 | Phosphorylation | PSRIVVVSSKLYKYG CCCEEEEECCEEEEC | 15.33 | 24719451 | |
| 192 | Phosphorylation | SRIVVVSSKLYKYGD CCEEEEECCEEEECC | 18.31 | 24719451 | |
| 195 | Phosphorylation | VVVSSKLYKYGDINF EEEECCEEEECCCCH | 13.10 | 24719451 | |
| 196 | Ubiquitination | VVSSKLYKYGDINFD EEECCEEEECCCCHH | 53.87 | - | |
| 211 | Phosphorylation | DLNSEQSYNKSFCYS HCCCCCCCCCCCCCC | 26.72 | - | |
| 213 | Ubiquitination | NSEQSYNKSFCYSRS CCCCCCCCCCCCCHH | 36.35 | - | |
| 238 | Phosphorylation | LARRLEGTNVTVNVL HHHHCCCCCEEEEEE | 19.69 | - | |
| 241 | Phosphorylation | RLEGTNVTVNVLHPG HCCCCCEEEEEECCC | 14.39 | - | |
| 307 | Ubiquitination | GRYFGDCKEEELLPK CCCCCCCCHHHHHCH | 73.27 | - | |
| 319 | Phosphorylation | LPKAMDESVARKLWD HCHHCCHHHHHHHHC | 19.47 | 29449344 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RDH14_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RDH14_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RDH14_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RDH14_HUMAN !! | ||||
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB00162 | Vitamin A |
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