NNTM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NNTM_HUMAN
• UniProt AC: Q13423
• Protein Name: NAD(P) transhydrogenase, mitochondrial
• Gene Name: NNT
• Organism: Homo sapiens (Human).
• Sequence Length: 1086
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein ; Matrix side .
• Protein Description: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland..
• Protein Sequence: MANLLKTVVTGCSCPLLSNLGSCKGLRVKKDFLRTFYTHQELWCKAPVKPGIPYKQLTVGVPKEIFQNEKRVALSPAGVQNLVKQGFNVVVESGAGEASKFSDDHYRVAGAQIQGAKEVLASDLVVKVRAPMVNPTLGVHEADLLKTSGTLISFIYPAQNPELLNKLSQRKTTVLAMDQVPRVTIAQGYDALSSMANIAGYKAVVLAANHFGRFFTGQITAAGKVPPAKILIVGGGVAGLASAGAAKSMGAIVRGFDTRAAALEQFKSLGAEPLEVDLKESGEGQGGYAKEMSKEFIEAEMKLFAQQCKEVDILISTALIPGKKAPVLFNKEMIESMKEGSVVVDLAAEAGGNFETTKPGELYIHKGITHIGYTDLPSRMATQASTLYSNNITKLLKAISPDKDNFYFDVKDDFDFGTMGHVIRGTVVMKDGKVIFPAPTPKNIPQGAPVKQKTVAELEAEKAATITPFRKTMSTASAYTAGLTGILGLGIAAPNLAFSQMVTTFGLAGIVGYHTVWGVTPALHSPLMSVTNAISGLTAVGGLALMGGHLYPSTTSQGLAALAAFISSVNIAGGFLVTQRMLDMFKRPTDPPEYNYLYLLPAGTFVGGYLAALYSGYNIEQIMYLGSGLCCVGALAGLSTQGTARLGNALGMIGVAGGLAATLGVLKPGPELLAQMSGAMALGGTIGLTIAKRIQISDLPQLVAAFHSLVGLAAVLTCIAEYIIEYPHFATDAAANLTKIVAYLGTYIGGVTFSGSLIAYGKLQGLLKSAPLLLPGRHLLNAGLLAASVGGIIPFMVDPSFTTGITCLGSVSALSAVMGVTLTAAIGGADMPVVITVLNSYSGWALCAEGFLLNNNLLTIVGALIGSSGAILSYIMCVAMNRSLANVILGGYGTTSTAGGKPMEISGTHTEINLDNAIDMIREANSIIITPGYGLCAAKAQYPIADLVKMLTEQGKKVRFGIHPVAGRMPGQLNVLLAEAGVPYDIVLEMDEINHDFPDTDLVLVIGANDTVNSAAQEDPNSIIAGMPVLEVWKSKQVIVMKRSLGVGYAAVDNPIFYKPNTAMLLGDAKKTCDALQAKVRESYQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	KDFLRTFYTHQELWC HHHHHHHCCCCCEEE	11.60	25367160
49	Ubiquitination	LWCKAPVKPGIPYKQ EEECCCCCCCCCHHH	36.15	-
55	Ubiquitination	VKPGIPYKQLTVGVP CCCCCCHHHEECCCC	33.21	21890473
63	Acetylation	QLTVGVPKEIFQNEK HEECCCCHHHHCCCC	62.12	30583097
70	2-Hydroxyisobutyrylation	KEIFQNEKRVALSPA HHHHCCCCCEECCHH	60.77	-
70	Acetylation	KEIFQNEKRVALSPA HHHHCCCCCEECCHH	60.77	19608861
70	Malonylation	KEIFQNEKRVALSPA HHHHCCCCCEECCHH	60.77	26320211
70	Succinylation	KEIFQNEKRVALSPA HHHHCCCCCEECCHH	60.77	27452117
75	Phosphorylation	NEKRVALSPAGVQNL CCCCEECCHHHHHHH	11.72	24275569
100	Malonylation	SGAGEASKFSDDHYR CCCCCHHHCCCCCCH	56.80	32601280
100	Acetylation	SGAGEASKFSDDHYR CCCCCHHHCCCCCCH	56.80	25825284
102	Phosphorylation	AGEASKFSDDHYRVA CCCHHHCCCCCCHHC	45.95	30576142
106	Phosphorylation	SKFSDDHYRVAGAQI HHCCCCCCHHCCCCC	17.49	30576142
117	Succinylation	GAQIQGAKEVLASDL CCCCCCHHHHHHHCE	56.00	-
117	Succinylation	GAQIQGAKEVLASDL CCCCCCHHHHHHHCE	56.00	23954790
117	Acetylation	GAQIQGAKEVLASDL CCCCCCHHHHHHHCE	56.00	23236377
122	Phosphorylation	GAKEVLASDLVVKVR CHHHHHHHCEEEEEE	27.58	21712546
150	Phosphorylation	DLLKTSGTLISFIYP HHHHCCCCEEEEEEC	22.23	21712546
166	Acetylation	QNPELLNKLSQRKTT CCHHHHHHHHHCCCE	49.86	23236377
171	2-Hydroxyisobutyrylation	LNKLSQRKTTVLAMD HHHHHHCCCEEEECC	40.69	-
171	Malonylation	LNKLSQRKTTVLAMD HHHHHHCCCEEEECC	40.69	26320211
172	Phosphorylation	NKLSQRKTTVLAMDQ HHHHHCCCEEEECCC	25.07	26270265
173	Phosphorylation	KLSQRKTTVLAMDQV HHHHCCCEEEECCCC	19.29	26270265
184	Phosphorylation	MDQVPRVTIAQGYDA CCCCCCEEEECCHHH	16.33	26270265
189	Phosphorylation	RVTIAQGYDALSSMA CEEEECCHHHHHHHH	5.98	26270265
193	Phosphorylation	AQGYDALSSMANIAG ECCHHHHHHHHHHCC	21.56	26270265
194	Phosphorylation	QGYDALSSMANIAGY CCHHHHHHHHHHCCH	23.82	26270265
202	Acetylation	MANIAGYKAVVLAAN HHHHCCHHHHHEEEC	33.51	30583109
224	Malonylation	GQITAAGKVPPAKIL CCEEECCCCCCCEEE	47.01	32601280
224	Acetylation	GQITAAGKVPPAKIL CCEEECCCCCCCEEE	47.01	25953088
224	Succinylation	GQITAAGKVPPAKIL CCEEECCCCCCCEEE	47.01	-
224	Succinylation	GQITAAGKVPPAKIL CCEEECCCCCCCEEE	47.01	-
242	Phosphorylation	GGVAGLASAGAAKSM CCHHHHHHHHHHHHC	32.07	28176443
267	Ubiquitination	AAALEQFKSLGAEPL HHHHHHHHHCCCCCE	44.45	-
279	Ubiquitination	EPLEVDLKESGEGQG CCEEEECHHHCCCCC	45.42	-
294	Succinylation	GYAKEMSKEFIEAEM CCHHHHHHHHHHHHH	56.16	-
294	Succinylation	GYAKEMSKEFIEAEM CCHHHHHHHHHHHHH	56.16	-
294	Acetylation	GYAKEMSKEFIEAEM CCHHHHHHHHHHHHH	56.16	26822725
323	Acetylation	STALIPGKKAPVLFN EECCCCCCCCCEECC	40.17	30583085
331	Succinylation	KAPVLFNKEMIESMK CCCEECCHHHHHHCC	41.13	-
331	Succinylation	KAPVLFNKEMIESMK CCCEECCHHHHHHCC	41.13	-
331	Acetylation	KAPVLFNKEMIESMK CCCEECCHHHHHHCC	41.13	19608861
336	Phosphorylation	FNKEMIESMKEGSVV CCHHHHHHCCCCCEE	24.99	29978859
341	Phosphorylation	IESMKEGSVVVDLAA HHHCCCCCEEEEEHH	16.90	29978859
356	Phosphorylation	EAGGNFETTKPGELY HCCCCCCCCCCCEEE	35.66	29978859
357	Phosphorylation	AGGNFETTKPGELYI CCCCCCCCCCCEEEE	28.22	29978859
369	Phosphorylation	LYIHKGITHIGYTDL EEEECCCCEEEECCC	18.99	23663014
373	Phosphorylation	KGITHIGYTDLPSRM CCCCEEEECCCCCHH	9.11	23663014
374	Phosphorylation	GITHIGYTDLPSRMA CCCEEEECCCCCHHH	26.33	23663014
378	Phosphorylation	IGYTDLPSRMATQAS EEECCCCCHHHHHHH	41.82	23663014
382	Phosphorylation	DLPSRMATQASTLYS CCCCHHHHHHHHHHH	18.48	23663014
385	Phosphorylation	SRMATQASTLYSNNI CHHHHHHHHHHHCCH	14.77	23663014
386	Phosphorylation	RMATQASTLYSNNIT HHHHHHHHHHHCCHH	32.50	23663014
388	Phosphorylation	ATQASTLYSNNITKL HHHHHHHHHCCHHHH	14.94	23663014
389	Phosphorylation	TQASTLYSNNITKLL HHHHHHHHCCHHHHH	26.89	23663014
393	Phosphorylation	TLYSNNITKLLKAIS HHHHCCHHHHHHHHC	20.12	23663014
394	Acetylation	LYSNNITKLLKAISP HHHCCHHHHHHHHCC	48.28	23954790
397	Acetylation	NNITKLLKAISPDKD CCHHHHHHHHCCCCC	54.86	19608861
403	Malonylation	LKAISPDKDNFYFDV HHHHCCCCCCEEEEE	58.94	32601280
403	Succinylation	LKAISPDKDNFYFDV HHHHCCCCCCEEEEE	58.94	23954790
403	Ubiquitination	LKAISPDKDNFYFDV HHHHCCCCCCEEEEE	58.94	-
403	Acetylation	LKAISPDKDNFYFDV HHHHCCCCCCEEEEE	58.94	26822725
407	Phosphorylation	SPDKDNFYFDVKDDF CCCCCCEEEEECCCC	12.72	-
419	Sulfoxidation	DDFDFGTMGHVIRGT CCCCCCCCCCEEEEE	3.41	28183972
430	Succinylation	IRGTVVMKDGKVIFP EEEEEEEECCEEEEE	52.28	23954790
433	Malonylation	TVVMKDGKVIFPAPT EEEEECCEEEEECCC	42.14	26320211
433	Succinylation	TVVMKDGKVIFPAPT EEEEECCEEEEECCC	42.14	23954790
433	Acetylation	TVVMKDGKVIFPAPT EEEEECCEEEEECCC	42.14	23236377
440	Phosphorylation	KVIFPAPTPKNIPQG EEEEECCCCCCCCCC	49.34	-
442	Ubiquitination	IFPAPTPKNIPQGAP EEECCCCCCCCCCCC	70.73	-
451	Ubiquitination	IPQGAPVKQKTVAEL CCCCCCCCCCCHHHH	45.05	-
462	Ubiquitination	VAELEAEKAATITPF HHHHHHHHHCCCCCC	50.82	-
677	Phosphorylation	PELLAQMSGAMALGG HHHHHHHHHHHHHCC	16.01	-
743	Phosphorylation	NLTKIVAYLGTYIGG HHHHHHHHHHHCCCC	8.51	26699800
746	Phosphorylation	KIVAYLGTYIGGVTF HHHHHHHHCCCCEEE	14.90	26699800
747	Phosphorylation	IVAYLGTYIGGVTFS HHHHHHHCCCCEEEC	8.86	26699800
752	Phosphorylation	GTYIGGVTFSGSLIA HHCCCCEEECCCHHH	18.50	26699800
754	Phosphorylation	YIGGVTFSGSLIAYG CCCCEEECCCHHHHH	20.36	26699800
756	Phosphorylation	GGVTFSGSLIAYGKL CCEEECCCHHHHHHH	18.53	26699800
760	Phosphorylation	FSGSLIAYGKLQGLL ECCCHHHHHHHHHHH	14.06	26699800
769	Phosphorylation	KLQGLLKSAPLLLPG HHHHHHHHCCEECCC	34.78	21712546
939	Succinylation	GYGLCAAKAQYPIAD CCCHHHHHCCCCHHH	19.93	23954790
942	Phosphorylation	LCAAKAQYPIADLVK HHHHHCCCCHHHHHH	11.06	-
1042	Acetylation	SKQVIVMKRSLGVGY CCEEEEEECCCCCCE	28.13	25953088
1059	Acetylation	VDNPIFYKPNTAMLL CCCCEECCCCHHEEC	22.50	30583103
1070	Succinylation	AMLLGDAKKTCDALQ HEECCCHHHHHHHHH	54.04	23954790
1070	Acetylation	AMLLGDAKKTCDALQ HEECCCHHHHHHHHH	54.04	160935
1071	Acetylation	MLLGDAKKTCDALQA EECCCHHHHHHHHHH	56.99	23749302
1079	Ubiquitination	TCDALQAKVRESYQK HHHHHHHHHHHHHCC	28.94	-
1079	Succinylation	TCDALQAKVRESYQK HHHHHHHHHHHHHCC	28.94	-
1079	Succinylation	TCDALQAKVRESYQK HHHHHHHHHHHHHCC	28.94	-
1079	Malonylation	TCDALQAKVRESYQK HHHHHHHHHHHHHCC	28.94	32601280
1079	Acetylation	TCDALQAKVRESYQK HHHHHHHHHHHHHCC	28.94	25953088
1079	2-Hydroxyisobutyrylation	TCDALQAKVRESYQK HHHHHHHHHHHHHCC	28.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NNTM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NNTM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NNTM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
QCR10_HUMAN	UQCR11	physical	22939629
TIM10_HUMAN	TIMM10	physical	22939629
OFUT1_HUMAN	POFUT1	physical	22939629
PTCD1_HUMAN	PTCD1	physical	22939629
PRPF3_HUMAN	PRPF3	physical	22939629
THY1_HUMAN	THY1	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
SF01_HUMAN	SF1	physical	22939629
S26A2_HUMAN	SLC26A2	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614736: Glucocorticoid deficiency 4 (GCCD4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70; LYS-100; LYS-331 ANDLYS-397, AND MASS SPECTROMETRY.
PubMed: 19608861