UniProt ID | LYRM7_HUMAN | |
---|---|---|
UniProt AC | Q5U5X0 | |
Protein Name | Complex III assembly factor LYRM7 | |
Gene Name | LYRM7 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 104 | |
Subcellular Localization | Mitochondrion matrix . | |
Protein Description | Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.. | |
Protein Sequence | MGRAVKVLQLFKTLHRTRQQVFKNDARALEAARIKINEEFKNNKSETSSKKIEELMKIGSDVELLLRTSVIQGIHTDHNTLKLVPRKDLLVENVPYCDAPTQKQ | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
6 | Ubiquitination | --MGRAVKVLQLFKT --CCHHHHHHHHHHH | 35.92 | 21890473 | |
6 | Ubiquitination | --MGRAVKVLQLFKT --CCHHHHHHHHHHH | 35.92 | 21890473 | |
23 | Acetylation | RTRQQVFKNDARALE HHHHHHHHHHHHHHH | 55.87 | 25953088 | |
45 | Phosphorylation | EEFKNNKSETSSKKI HHHHCCCCCCCHHHH | 48.51 | 26074081 | |
47 | Phosphorylation | FKNNKSETSSKKIEE HHCCCCCCCHHHHHH | 45.45 | 26074081 | |
48 | Phosphorylation | KNNKSETSSKKIEEL HCCCCCCCHHHHHHH | 35.79 | 26074081 | |
49 | Phosphorylation | NNKSETSSKKIEELM CCCCCCCHHHHHHHH | 45.44 | 26074081 | |
60 | Phosphorylation | EELMKIGSDVELLLR HHHHHCCCCHHHHHH | 41.79 | 30108239 | |
82 | Ubiquitination | HTDHNTLKLVPRKDL CCCCCCEEEEECHHH | 45.45 | 21890473 | |
82 | Ubiquitination | HTDHNTLKLVPRKDL CCCCCCEEEEECHHH | 45.45 | 21890473 | |
87 | Ubiquitination | TLKLVPRKDLLVENV CEEEEECHHHEECCC | 46.81 | 21890473 | |
87 | Ubiquitination | TLKLVPRKDLLVENV CEEEEECHHHEECCC | 46.81 | 21890473 | |
97 | Glutathionylation | LVENVPYCDAPTQKQ EECCCCCCCCCCCCC | 2.70 | 22555962 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LYRM7_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LYRM7_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LYRM7_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
A4_HUMAN | APP | physical | 21832049 | |
UCRI_HUMAN | UQCRFS1 | physical | 23168492 | |
LYRM7_HUMAN | LYRM7 | physical | 27499296 | |
UCRI_HUMAN | UQCRFS1 | physical | 27499296 | |
ACPM_HUMAN | NDUFAB1 | physical | 27499296 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
OMIM Disease | ||||||
615838 | Mitochondrial complex III deficiency, nuclear 8 (MC3DN8) | |||||
Kegg Drug | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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