ETFD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ETFD_HUMAN
• UniProt AC: Q16134
• Protein Name: Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
• Gene Name: ETFDH
• Organism: Homo sapiens (Human).
• Sequence Length: 617
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: Accepts electrons from ETF and reduces ubiquinone..
• Protein Sequence: MLVPLAKLSCLAYQCFHALKIKKNYLPLCATRWSSTSTVPRITTHYTIYPRDKDKRWEGVNMERFAEEADVVIVGAGPAGLSAAVRLKQLAVAHEKDIRVCLVEKAAQIGAHTLSGACLDPGAFKELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILPGLPMNNHGNYIVRLGHLVSWMGEQAEALGVEVYPGYAAAEVLFHDDGSVKGIATNDVGIQKDGAPKATFERGLELHAKVTIFAEGCHGHLAKQLYKKFDLRANCEPQTYGIGLKELWVIDEKNWKPGRVDHTVGWPLDRHTYGGSFLYHLNEGEPLVALGLVVGLDYQNPYLSPFREFQRWKHHPSIRPTLEGGKRIAYGARALNEGGFQSIPKLTFPGGLLIGCSPGFMNVPKIKGTHTAMKSGILAAESIFNQLTSENLQSKTIGLHVTEYEDNLKNSWVWKELYSVRNIRPSCHGVLGVYGGMIYTGIFYWILRGMEPWTLKHKGSDFERLKPAKDCTPIEYPKPDGQISFDLLSSVALSGTNHEHDQPAHLTLRDDSIPVNRNLSIYDGPEQRFCPAGVYEFVPVEQGDGFRLQINAQNCVHCKTCDIKDPSQNINWVVPEGGGGPAYNGM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	NYLPLCATRWSSTST CCCCCEEECCCCCCC	31.51	-
46	Phosphorylation	VPRITTHYTIYPRDK CCCEEEEEEEEECCC	7.85	27080861
47	Phosphorylation	PRITTHYTIYPRDKD CCEEEEEEEEECCCC	13.36	27080861
88	Ubiquitination	LSAAVRLKQLAVAHE HHHHHHHHHHHHHCC	32.47	-
96	Acetylation	QLAVAHEKDIRVCLV HHHHHCCCCEEEEEH	48.89	-
106	Ubiquitination	RVCLVEKAAQIGAHT EEEEHHHHHHCCCCC	7.35	-
125	Acetylation	CLDPGAFKELFPDWK CCCCCHHHHHCCCHH	53.63	25038526
132	Ubiquitination	KELFPDWKEKGAPLN HHHCCCHHHCCCCCC	57.86	-
132	Acetylation	KELFPDWKEKGAPLN HHHCCCHHHCCCCCC	57.86	25953088
140	Phosphorylation	EKGAPLNTPVTEDRF HCCCCCCCCCCCCCC	27.15	23403867
143	Phosphorylation	APLNTPVTEDRFGIL CCCCCCCCCCCCCCC	33.11	23403867
153	Ubiquitination	RFGILTEKYRIPVPI CCCCCCCCCCCCCCC	34.30	-
172	Phosphorylation	PMNNHGNYIVRLGHL CCCCCCCEEEEHHHH	12.84	-
216	Phosphorylation	GSVKGIATNDVGIQK CCEEEEEECCCCCCC	29.99	20393185
223	Ubiquitination	TNDVGIQKDGAPKAT ECCCCCCCCCCCCCC	57.09	-
223	Malonylation	TNDVGIQKDGAPKAT ECCCCCCCCCCCCCC	57.09	26320211
223	Acetylation	TNDVGIQKDGAPKAT ECCCCCCCCCCCCCC	57.09	-
335	Phosphorylation	DYQNPYLSPFREFQR CCCCCCCCCHHHHHH	19.02	24719451
348	Phosphorylation	QRWKHHPSIRPTLEG HHHCCCCCCCCCCCC	27.20	24719451
352	Phosphorylation	HHPSIRPTLEGGKRI CCCCCCCCCCCCCEE	27.82	27080861
357	Ubiquitination	RPTLEGGKRIAYGAR CCCCCCCCEEEECCC	52.03	-
357	Acetylation	RPTLEGGKRIAYGAR CCCCCCCCEEEECCC	52.03	2380449
361	Phosphorylation	EGGKRIAYGARALNE CCCCEEEECCCCCCC	14.67	22817900
373	Phosphorylation	LNEGGFQSIPKLTFP CCCCCCCCCCCCEEC	38.30	-
425	Phosphorylation	LTSENLQSKTIGLHV HHCCCHHHCCEEEEE	34.63	21214269
427	Phosphorylation	SENLQSKTIGLHVTE CCCHHHCCEEEEEEE	26.06	21214269
433	Phosphorylation	KTIGLHVTEYEDNLK CCEEEEEEEEHHHCC	23.31	21214269
435	Phosphorylation	IGLHVTEYEDNLKNS EEEEEEEEHHHCCCC	21.15	21214269
551	Phosphorylation	IPVNRNLSIYDGPEQ CCCCCCCCCCCCCCC	23.74	17412732
561	Glutathionylation	DGPEQRFCPAGVYEF CCCCCCCCCCCEEEE	2.16	22555962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ETFD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ETFD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ETFD_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ETFD_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00178: Glutaric acidemia, including: Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Mul
• OMIM Disease
• 231680: Glutaric aciduria 2C (GA2C)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.