SCPDL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCPDL_HUMAN
• UniProt AC: Q8NBX0
• Protein Name: Saccharopine dehydrogenase-like oxidoreductase
• Gene Name: SCCPDH
• Organism: Homo sapiens (Human).
• Sequence Length: 429
• Protein Sequence: MATEQRPFHLVVFGASGFTGQFVTEEVAREQVDPERSSRLPWAVAGRSREKLQRVLEKAALKLGRPTLSSEVGIIICDIANPASLDEMAKQATVVLNCVGPYRFYGEPVIKACIENGASCIDISGEPQFLELMQLKYHEKAADKGVYIIGSSGFDSIPADLGVIYTRNKMNGTLTAVESFLTIHSGPEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQLLIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYVATPIAMVQAAMTLLSDASHLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATEQRPFH ------CCCCCCCEE	21.61	-
58	Acetylation	KLQRVLEKAALKLGR HHHHHHHHHHHHCCC	34.50	25953088
58	2-Hydroxyisobutyrylation	KLQRVLEKAALKLGR HHHHHHHHHHHHCCC	34.50	-
58	Ubiquitination	KLQRVLEKAALKLGR HHHHHHHHHHHHCCC	34.50	-
136	Acetylation	FLELMQLKYHEKAAD HHHHHHHHHHHHHCC	27.89	25038526
140	Ubiquitination	MQLKYHEKAADKGVY HHHHHHHHHCCCCEE	35.25	-
144	Ubiquitination	YHEKAADKGVYIIGS HHHHHCCCCEEEECC	45.62	-
199	Phosphorylation	IHDGTWKSAIYGFGD ECCCCCEECEECCCC	16.09	26437602
202	Phosphorylation	GTWKSAIYGFGDQSN CCCEECEECCCCHHH	13.20	24641631
208	Phosphorylation	IYGFGDQSNLRKLRN EECCCCHHHHHHHCC	42.44	28857561
212	Ubiquitination	GDQSNLRKLRNVSNL CCHHHHHHHCCCCCC	55.77	-
217	Phosphorylation	LRKLRNVSNLKPVPL HHHHCCCCCCCCCCC	39.74	25072903
220	Ubiquitination	LRNVSNLKPVPLIGP HCCCCCCCCCCCCCH	48.49	21890473
228	Ubiquitination	PVPLIGPKLKRRWPI CCCCCCHHHHCCCCC	62.52	-
228	Acetylation	PVPLIGPKLKRRWPI CCCCCCHHHHCCCCC	62.52	25953088
242	Ubiquitination	ISYCRELKGYSIPFM CCHHHHCCCCCCCCC	51.56	-
251	Phosphorylation	YSIPFMGSDVSVVRR CCCCCCCCCHHHHHH	24.05	28122231
254	Phosphorylation	PFMGSDVSVVRRTQR CCCCCCHHHHHHHHH	21.64	25693802
359	Ubiquitination	DKNKPNIKICTQVKG CCCCCCEEEEEECCC	38.07	-
362	Phosphorylation	KPNIKICTQVKGPEA CCCEEEEEECCCCCC	39.61	24719451
394	Ubiquitination	SDASHLPKAGGVFTP HCHHCCCCCCCCCCC	67.05	-
400	Phosphorylation	PKAGGVFTPGAAFSK CCCCCCCCCCCCCCH	20.57	-
406	Phosphorylation	FTPGAAFSKTKLIDR CCCCCCCCHHHHHHH	34.39	30622161
407	Ubiquitination	TPGAAFSKTKLIDRL CCCCCCCHHHHHHHH	43.13	-
409	Ubiquitination	GAAFSKTKLIDRLNK CCCCCHHHHHHHHHH	47.37	-
425	Phosphorylation	GIEFSVISSSEV--- CCEEEEEECCCC---	26.17	-
426	Phosphorylation	IEFSVISSSEV---- CEEEEEECCCC----	21.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCPDL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCPDL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCPDL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM160_HUMAN	TMEM160	physical	26186194
MYOME_HUMAN	PDE4DIP	physical	26186194
RPN1_HUMAN	RPN1	physical	26186194
ZZEF1_HUMAN	ZZEF1	physical	26186194
RAB4A_HUMAN	RAB4A	physical	26186194
UBP13_HUMAN	USP13	physical	26186194
SQSTM_HUMAN	SQSTM1	physical	26186194
PAIP2_HUMAN	PAIP2	physical	26186194
HECD3_HUMAN	HECTD3	physical	26186194
MIEN1_HUMAN	MIEN1	physical	26186194
SAAL1_HUMAN	SAAL1	physical	26186194
WAPL_HUMAN	WAPAL	physical	26186194
TAF1_HUMAN	TAF1	physical	26186194
KBTB7_HUMAN	KBTBD7	physical	26186194
CPT2_HUMAN	CPT2	physical	26344197
GLRX1_HUMAN	GLRX	physical	26344197
UBP13_HUMAN	USP13	physical	28514442
MYOME_HUMAN	PDE4DIP	physical	28514442
RAB4A_HUMAN	RAB4A	physical	28514442
WAPL_HUMAN	WAPAL	physical	28514442
RPN1_HUMAN	RPN1	physical	28514442
TM160_HUMAN	TMEM160	physical	28514442
PAIP2_HUMAN	PAIP2	physical	28514442
SQSTM_HUMAN	SQSTM1	physical	28514442
ZZEF1_HUMAN	ZZEF1	physical	28514442
SAAL1_HUMAN	SAAL1	physical	28514442
HECD3_HUMAN	HECTD3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.