GLRX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLRX1_HUMAN
• UniProt AC: P35754
• Protein Name: Glutaredoxin-1
• Gene Name: GLRX
• Organism: Homo sapiens (Human).
• Sequence Length: 106
• Subcellular Localization: Cytoplasm.
• Protein Description: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins..
• Protein Sequence: MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQEFVNCK ------CCCCCCCCE	20.01	19413330
8	S-nitrosocysteine	MAQEFVNCKIQPGKV CCCCCCCCEECCCCE	3.27	-
8	S-nitrosylation	MAQEFVNCKIQPGKV CCCCCCCCEECCCCE	3.27	22178444
9	Succinylation	AQEFVNCKIQPGKVV CCCCCCCEECCCCEE	38.89	-
9	Ubiquitination	AQEFVNCKIQPGKVV CCCCCCCEECCCCEE	38.89	-
9	Succinylation	AQEFVNCKIQPGKVV CCCCCCCEECCCCEE	38.89	-
9	Acetylation	AQEFVNCKIQPGKVV CCCCCCCEECCCCEE	38.89	23749302
20	Ubiquitination	GKVVVFIKPTCPYCR CCEEEEECCCCHHHH	23.86	21890473
20	Acetylation	GKVVVFIKPTCPYCR CCEEEEECCCCHHHH	23.86	23749302
20	Malonylation	GKVVVFIKPTCPYCR CCEEEEECCCCHHHH	23.86	26320211
22	Phosphorylation	VVVFIKPTCPYCRRA EEEEECCCCHHHHHH	22.55	28152594
23	Glutathionylation	VVFIKPTCPYCRRAQ EEEECCCCHHHHHHH	2.83	9860827
25	Phosphorylation	FIKPTCPYCRRAQEI EECCCCHHHHHHHHH	10.75	28152594
34	Phosphorylation	RRAQEILSQLPIKQG HHHHHHHHCCCCCCC	35.02	26437602
65	O-linked_Glycosylation	QDYLQQLTGARTVPR HHHHHHHHCCCCCCE	25.18	29351928
79	S-nitrosocysteine	RVFIGKDCIGGCSDL EEEECCCCCCCHHHH	3.38	-
79	S-nitrosylation	RVFIGKDCIGGCSDL EEEECCCCCCCHHHH	3.38	22178444
83	S-nitrosylation	GKDCIGGCSDLVSLQ CCCCCCCHHHHHHHH	2.11	22178444
83	S-nitrosocysteine	GKDCIGGCSDLVSLQ CCCCCCCHHHHHHHH	2.11	-
84	Phosphorylation	KDCIGGCSDLVSLQQ CCCCCCHHHHHHHHH	36.94	28258704
100	Malonylation	GELLTRLKQIGALQ- HHHHHHHHHHCCCC-	36.26	26320211
100	Ubiquitination	GELLTRLKQIGALQ- HHHHHHHHHHCCCC-	36.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLRX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLRX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLRX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATP7A_HUMAN	ATP7A	physical	16884690
ATP7B_HUMAN	ATP7B	physical	16884690
M3K5_HUMAN	MAP3K5	physical	12244106
AATM_HUMAN	GOT2	physical	21900206
MMP23_HUMAN	MMP23B	physical	21988832
NIT1_HUMAN	NIT1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330