| UniProt ID | ATP7B_HUMAN | |
|---|---|---|
| UniProt AC | P35670 | |
| Protein Name | Copper-transporting ATPase 2 | |
| Gene Name | ATP7B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1465 | |
| Subcellular Localization |
Golgi apparatus, trans-Golgi network membrane Multi-pass membrane protein . Late endosome . Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicle |
|
| Protein Description | Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.. | |
| Protein Sequence | MPEQERQITAREGASRKILSKLSLPTRAWEPAMKKSFAFDNVGYEGGLDGLGPSSQVATSTVRILGMTCQSCVKSIEDRISNLKGIISMKVSLEQGSATVKYVPSVVCLQQVCHQIGDMGFEASIAEGKAASWPSRSLPAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVNDMGFEAAIKSKVAPLSLGPIDIERLQSTNPKRPLSSANQNFNNSETLGHQGSHVVTLQLRIDGMHCKSCVLNIEENIGQLLGVQSIQVSLENKTAQVKYDPSCTSPVALQRAIEALPPGNFKVSLPDGAEGSGTDHRSSSSHSPGSPPRNQVQGTCSTTLIAIAGMTCASCVHSIEGMISQLEGVQQISVSLAEGTATVLYNPSVISPEELRAAIEDMGFEASVVSESCSTNPLGNHSAGNSMVQTTDGTPTSVQEVAPHTGRLPANHAPDILAKSPQSTRAVAPQKCFLQIKGMTCASCVSNIERNLQKEAGVLSVLVALMAGKAEIKYDPEVIQPLEIAQFIQDLGFEAAVMEDYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVMALMIYMLIPSNEPHQSMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYKSLRHRSANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHLAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIVKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIMSTLTLVVWIVIGFIDFGVVQRYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLGDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGILAHSERPLSAPASHLNEAGSLPAEKDAVPQTFSVLIGNREWLRRNGLTISSDVSDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKQEAALAVHTLQSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAHGHMKPLTASQVSVHIGMDDRWRDSPRATPWDQVSYVSQVSLSSLTSDKPSRHSAAADDDGDKWSLLLNGRDEEQYI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | PEQERQITAREGASR CHHHHHHHHHCCHHH | 16.01 | - | |
| 20 | Phosphorylation | GASRKILSKLSLPTR CHHHHHHHHCCCCCC | 34.72 | 23186163 | |
| 23 | Phosphorylation | RKILSKLSLPTRAWE HHHHHHCCCCCCCCC | 35.72 | 29978859 | |
| 26 | Phosphorylation | LSKLSLPTRAWEPAM HHHCCCCCCCCCCHH | 38.01 | 23186163 | |
| 44 | Phosphorylation | FAFDNVGYEGGLDGL CCCCCCCCCCCCCCC | 13.71 | 27642862 | |
| 132 | Phosphorylation | IAEGKAASWPSRSLP HHCCCCCCCCCCCCC | 44.36 | 23403867 | |
| 135 | Phosphorylation | GKAASWPSRSLPAQE CCCCCCCCCCCCHHH | 28.39 | 23403867 | |
| 137 | Phosphorylation | AASWPSRSLPAQEAV CCCCCCCCCCHHHHE | 42.94 | 23403867 | |
| 177 | Phosphorylation | GVVRVKVSLSNQEAV CEEEEEEEECCCEEE | 21.99 | 24043423 | |
| 179 | Phosphorylation | VRVKVSLSNQEAVIT EEEEEEECCCEEEEE | 29.03 | 24043423 | |
| 186 | Phosphorylation | SNQEAVITYQPYLIQ CCCEEEEEEECEECC | 14.98 | 24043423 | |
| 187 | Phosphorylation | NQEAVITYQPYLIQP CCEEEEEEECEECCH | 9.07 | 24043423 | |
| 190 | Phosphorylation | AVITYQPYLIQPEDL EEEEEECEECCHHHH | 10.83 | 24043423 | |
| 218 | Phosphorylation | KSKVAPLSLGPIDIE HCCCCCCCCCCCCHH | 30.16 | 30266825 | |
| 229 | Phosphorylation | IDIERLQSTNPKRPL CCHHHHHCCCCCCCC | 34.44 | - | |
| 301 | Phosphorylation | NKTAQVKYDPSCTSP CCCCEEECCCCCCCH | 33.94 | 29209046 | |
| 304 | Phosphorylation | AQVKYDPSCTSPVAL CEEECCCCCCCHHHH | 27.42 | 29209046 | |
| 306 | Phosphorylation | VKYDPSCTSPVALQR EECCCCCCCHHHHHH | 40.16 | 29209046 | |
| 307 | Phosphorylation | KYDPSCTSPVALQRA ECCCCCCCHHHHHHH | 23.00 | 29209046 | |
| 340 | Phosphorylation | GSGTDHRSSSSHSPG CCCCCCCCCCCCCCC | 31.02 | 23312004 | |
| 341 | Phosphorylation | SGTDHRSSSSHSPGS CCCCCCCCCCCCCCC | 35.50 | 23312004 | |
| 342 | Phosphorylation | GTDHRSSSSHSPGSP CCCCCCCCCCCCCCC | 33.06 | 25002506 | |
| 343 | Phosphorylation | TDHRSSSSHSPGSPP CCCCCCCCCCCCCCC | 29.90 | 25002506 | |
| 345 | Phosphorylation | HRSSSSHSPGSPPRN CCCCCCCCCCCCCCH | 32.67 | 23312004 | |
| 348 | Phosphorylation | SSSHSPGSPPRNQVQ CCCCCCCCCCCHHCC | 34.81 | 28857561 | |
| 378 (in isoform 3) | Ubiquitination | - | 45.80 | 21890473 | |
| 477 | Ubiquitination | HAPDILAKSPQSTRA CCCHHHHCCCCCCCC | 60.26 | - | |
| 478 | Phosphorylation | APDILAKSPQSTRAV CCHHHHCCCCCCCCC | 23.67 | 29978859 | |
| 481 | Phosphorylation | ILAKSPQSTRAVAPQ HHHCCCCCCCCCCCC | 24.20 | 29978859 | |
| 482 | Phosphorylation | LAKSPQSTRAVAPQK HHCCCCCCCCCCCCC | 19.87 | 23186163 | |
| 489 (in isoform 1) | Ubiquitination | - | 26.37 | 21890473 | |
| 489 | Ubiquitination | TRAVAPQKCFLQIKG CCCCCCCCEEEEECC | 26.37 | 21890473 | |
| 489 (in isoform 2) | Ubiquitination | - | 26.37 | 21890473 | |
| 489 (in isoform 4) | Ubiquitination | - | 26.37 | 21890473 | |
| 496 (in isoform 3) | Ubiquitination | - | 20.47 | 21890473 | |
| 518 | Phosphorylation | QKEAGVLSVLVALMA HHHHHHHHHHHHHHH | 15.82 | - | |
| 587 | Phosphorylation | HNIESKLTRTNGITY HHHHCHHHCCCCCCH | 38.90 | 28842319 | |
| 589 | Phosphorylation | IESKLTRTNGITYAS HHCHHHCCCCCCHHH | 32.34 | 23312004 | |
| 593 | Phosphorylation | LTRTNGITYASVALA HHCCCCCCHHHHHHH | 17.90 | 23312004 | |
| 594 | Phosphorylation | TRTNGITYASVALAT HCCCCCCHHHHHHHH | 8.58 | 23312004 | |
| 596 | Phosphorylation | TNGITYASVALATSK CCCCCHHHHHHHHCC | 9.48 | 23312004 | |
| 607 (in isoform 2) | Ubiquitination | - | 44.92 | 21890473 | |
| 607 (in isoform 1) | Ubiquitination | - | 44.92 | 21890473 | |
| 607 | Ubiquitination | ATSKALVKFDPEIIG HHCCHHHCCCHHHHC | 44.92 | 21890473 | |
| 607 (in isoform 4) | Ubiquitination | - | 44.92 | 21890473 | |
| 787 | Ubiquitination | LEHLAKSKTSEALAK HHHHHCCCCHHHHHH | 56.20 | - | |
| 788 | O-linked_Glycosylation | EHLAKSKTSEALAKL HHHHCCCCHHHHHHH | 38.60 | 30379171 | |
| 821 (in isoform 2) | Ubiquitination | - | 15.38 | 21890473 | |
| 876 | Phosphorylation | GSTVIAGSINAHGSV CCEEEEEEECCCCCE | 12.03 | 23879269 | |
| 882 | Phosphorylation | GSINAHGSVLIKATH EEECCCCCEEEEEEE | 12.13 | 23879269 | |
| 910 | Ubiquitination | VEEAQMSKAPIQQLA HHHHHHCCCCHHHHH | 53.49 | - | |
| 917 (in isoform 3) | Ubiquitination | - | 11.12 | 21890473 | |
| 1010 (in isoform 4) | Ubiquitination | - | 59.16 | 21890473 | |
| 1028 (in isoform 1) | Ubiquitination | - | 37.27 | 21890473 | |
| 1028 | Ubiquitination | IKTVMFDKTGTITHG CCEEEECCCCCCCCC | 37.27 | 21890473 | |
| 1028 | Acetylation | IKTVMFDKTGTITHG CCEEEECCCCCCCCC | 37.27 | 7307309 | |
| 1050 | Phosphorylation | LLLGDVATLPLRKVL HHHCCCCCCCHHHHH | 28.85 | - | |
| 1066 | Phosphorylation | VVGTAEASSEHPLGV HHCCCCCCCCCCCHH | 27.97 | 23532336 | |
| 1076 | Phosphorylation | HPLGVAVTKYCKEEL CCCHHHHHHHHHHHH | 13.42 | - | |
| 1078 | Phosphorylation | LGVAVTKYCKEELGT CHHHHHHHHHHHHCC | 10.21 | 23532336 | |
| 1121 | Phosphorylation | AHSERPLSAPASHLN CCCCCCCCCCHHHCC | 34.58 | 22817900 | |
| 1208 | Phosphorylation | EAALAVHTLQSMGVD HHHHHHHHHHHCCCC | 21.64 | - | |
| 1211 | Phosphorylation | LAVHTLQSMGVDVVL HHHHHHHHCCCCEEE | 22.18 | - | |
| 1220 | Phosphorylation | GVDVVLITGDNRKTA CCCEEEEECCCHHHH | 34.03 | - | |
| 1258 | Acetylation | KVQELQNKGKKVAMV HHHHHHHCCCCEEEE | 60.18 | 7668361 | |
| 1260 | Acetylation | QELQNKGKKVAMVGD HHHHHCCCCEEEECC | 45.76 | 7668371 | |
| 1310 | Phosphorylation | DLLDVVASIHLSKRT CHHHHHHHHHCCHHH | 10.03 | 26270265 | |
| 1314 | Phosphorylation | VVASIHLSKRTVRRI HHHHHHCCHHHHHHH | 13.11 | 26270265 | |
| 1398 | Phosphorylation | HMKPLTASQVSVHIG CCCCCCHHHEEEEEC | 26.36 | 20363803 | |
| 1401 | Phosphorylation | PLTASQVSVHIGMDD CCCHHHEEEEECCCC | 10.59 | 20363803 | |
| 1413 | Phosphorylation | MDDRWRDSPRATPWD CCCCCCCCCCCCCHH | 14.01 | - | |
| 1423 | Phosphorylation | ATPWDQVSYVSQVSL CCCHHHHHEEEEEEH | 17.74 | - | |
| 1424 | Phosphorylation | TPWDQVSYVSQVSLS CCHHHHHEEEEEEHH | 12.79 | 27642862 | |
| 1426 | Phosphorylation | WDQVSYVSQVSLSSL HHHHHEEEEEEHHHC | 19.34 | 27251275 | |
| 1429 | Phosphorylation | VSYVSQVSLSSLTSD HHEEEEEEHHHCCCC | 18.20 | 24719451 | |
| 1442 | Phosphorylation | SDKPSRHSAAADDDG CCCCCCCCCCCCCCC | 20.63 | 26471730 | |
| 1453 | Phosphorylation | DDDGDKWSLLLNGRD CCCCCCEEEEECCCC | 18.19 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 478 | S | Phosphorylation | Kinase | PRKD1 | Q15139 | PSP |
| 481 | S | Phosphorylation | Kinase | PRKD1 | Q15139 | PSP |
| 1121 | S | Phosphorylation | Kinase | PRKD1 | Q15139 | PSP |
| 1453 | S | Phosphorylation | Kinase | PRKD1 | Q15139 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ATP7B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ATP7B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GLRX1_HUMAN | GLRX | physical | 16884690 | |
| ATOX1_HUMAN | ATOX1 | physical | 10497213 | |
| ATOX1_HUMAN | ATOX1 | physical | 10557326 | |
| DCTN4_HUMAN | DCTN4 | physical | 16554302 | |
| COMD1_HUMAN | COMMD1 | physical | 12968035 | |
| ATOX1_HUMAN | ATOX1 | physical | 16573520 | |
| ZBT16_HUMAN | ZBTB16 | physical | 16676348 | |
| HPT_HUMAN | HP | physical | 16676348 | |
| CLUS_HUMAN | CLU | physical | 21242307 | |
| CLUS_HUMAN | CLU | physical | 22130675 | |
| COMD1_HUMAN | COMMD1 | physical | 22130675 |
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