ATOX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATOX1_HUMAN
• UniProt AC: O00244
• Protein Name: Copper transport protein ATOX1
• Gene Name: ATOX1
• Organism: Homo sapiens (Human).
• Sequence Length: 68
• Protein Description: Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense..
• Protein Sequence: MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTLLATLKKTGKTVSYLGLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MPKHEFSVDMTCGG -CCCCCCEECCCCHH	17.77	-
11	Phosphorylation	HEFSVDMTCGGCAEA CCCEECCCCHHHHHH	11.97	26091039
25	Ubiquitination	AVSRVLNKLGGVKYD HHHHHHHHCCCCEEE	44.33	23000965
25	2-Hydroxyisobutyrylation	AVSRVLNKLGGVKYD HHHHHHHHCCCCEEE	44.33	-
25	Acetylation	AVSRVLNKLGGVKYD HHHHHHHHCCCCEEE	44.33	23749302
30	Ubiquitination	LNKLGGVKYDIDLPN HHHCCCCEEEEECCC	40.24	23000965
30	Acetylation	LNKLGGVKYDIDLPN HHHCCCCEEEEECCC	40.24	26051181
38	Ubiquitination	YDIDLPNKKVCIESE EEEECCCCEEEEEEC	44.64	33845483
38	Acetylation	YDIDLPNKKVCIESE EEEECCCCEEEEEEC	44.64	25953088
38	2-Hydroxyisobutyrylation	YDIDLPNKKVCIESE EEEECCCCEEEEEEC	44.64	-
41	Glutathionylation	DLPNKKVCIESEHSM ECCCCEEEEEECCCH	3.82	22555962
44	Phosphorylation	NKKVCIESEHSMDTL CCEEEEEECCCHHHH	22.24	28450419
47	Phosphorylation	VCIESEHSMDTLLAT EEEEECCCHHHHHHH	17.82	29255136
50	Phosphorylation	ESEHSMDTLLATLKK EECCCHHHHHHHHHH	18.28	28192239
54	Phosphorylation	SMDTLLATLKKTGKT CHHHHHHHHHHHCCE	38.79	29255136
56	Ubiquitination	DTLLATLKKTGKTVS HHHHHHHHHHCCEEE	43.89	32015554
56	2-Hydroxyisobutyrylation	DTLLATLKKTGKTVS HHHHHHHHHHCCEEE	43.89	-
56	Acetylation	DTLLATLKKTGKTVS HHHHHHHHHHCCEEE	43.89	25953088
57	Acetylation	TLLATLKKTGKTVSY HHHHHHHHHCCEEEE	66.67	23954790
57	Malonylation	TLLATLKKTGKTVSY HHHHHHHHHCCEEEE	66.67	26320211
60	Ubiquitination	ATLKKTGKTVSYLGL HHHHHHCCEEEECCC	51.49	33845483
60	Acetylation	ATLKKTGKTVSYLGL HHHHHHCCEEEECCC	51.49	23749302
60	Malonylation	ATLKKTGKTVSYLGL HHHHHHCCEEEECCC	51.49	26320211
63	Phosphorylation	KKTGKTVSYLGLE-- HHHCCEEEECCCC--	21.63	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATOX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATOX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATOX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATP7B_HUMAN	ATP7B	physical	10557326
ATP7A_HUMAN	ATP7A	physical	12679332
ATP7B_HUMAN	ATP7B	physical	12968035
ATP7B_HUMAN	ATP7B	physical	17919502
CU002_HUMAN	C21orf2	physical	25416956
GGPPS_HUMAN	GGPS1	physical	25416956
F118A_HUMAN	FAM118A	physical	25416956
GSTT1_HUMAN	GSTT1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.