ATP7A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATP7A_HUMAN
• UniProt AC: Q04656
• Protein Name: Copper-transporting ATPase 1
• Gene Name: ATP7A
• Organism: Homo sapiens (Human).
• Sequence Length: 1500
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cycles constitutively between the trans-Golgi network (TGN) and the plasma membrane (PubMed:9147644). Predominantly found in t
• Protein Description: May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells..
• Protein Sequence: MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRETVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFREDDDTAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	IYDPKLQTPKTLQEA EECCCCCCCHHHHHH	36.87	24719451
147	Phosphorylation	KELVPELSLDTGTLE HHHHCCCCCCCCCCE	23.65	29255136
150	Phosphorylation	VPELSLDTGTLEKKS HCCCCCCCCCCEECC	37.04	30266825
152	Phosphorylation	ELSLDTGTLEKKSGA CCCCCCCCCEECCCC	33.56	30266825
155	Ubiquitination	LDTGTLEKKSGACED CCCCCCEECCCCCCC	56.18	-
195	Ubiquitination	TIEGKIGKLQGVQRI EECCCCCEECCEEEE	40.90	-
226	Acetylation	LISVEEMKKQIEAMG ECCHHHHHHHHHHCC	44.82	7469333
227	Acetylation	ISVEEMKKQIEAMGF CCHHHHHHHHHHCCC	56.02	7469345
239	Acetylation	MGFPAFVKKQPKYLK CCCCHHHCCCCCEEE	38.96	7469357
244	Phosphorylation	FVKKQPKYLKLGAID HHCCCCCEEECCCCC	18.76	-
246	Ubiquitination	KKQPKYLKLGAIDVE CCCCCEEECCCCCHH	41.61	-
262	Phosphorylation	LKNTPVKSSEGSQQR HCCCCCCCCCCCCCC	33.58	30108239
263	Phosphorylation	KNTPVKSSEGSQQRS CCCCCCCCCCCCCCC	40.01	30108239
266	Phosphorylation	PVKSSEGSQQRSPSY CCCCCCCCCCCCCCC	21.06	30108239
270	Phosphorylation	SEGSQQRSPSYTNDS CCCCCCCCCCCCCCC	17.54	25159151
272	Phosphorylation	GSQQRSPSYTNDSTA CCCCCCCCCCCCCCE	45.92	27794612
273	Phosphorylation	SQQRSPSYTNDSTAT CCCCCCCCCCCCCEE	16.97	21712546
274	Phosphorylation	QQRSPSYTNDSTATF CCCCCCCCCCCCEEE	36.57	21712546
277	Phosphorylation	SPSYTNDSTATFIID CCCCCCCCCEEEEEE	23.24	23663014
278	Phosphorylation	PSYTNDSTATFIIDG CCCCCCCCEEEEEEC	32.36	23898821
280	Phosphorylation	YTNDSTATFIIDGMH CCCCCCEEEEEECCC	18.56	23663014
316	Phosphorylation	VVSLENRSAIVKYNA EEEECCCCEEEEEEC	33.65	29759185
321	Phosphorylation	NRSAIVKYNASSVTP CCCEEEEEECCCCCH	12.69	29759185
324	Phosphorylation	AIVKYNASSVTPESL EEEEEECCCCCHHHH	23.00	28450419
325	Phosphorylation	IVKYNASSVTPESLR EEEEECCCCCHHHHH	27.83	28450419
327	Phosphorylation	KYNASSVTPESLRKA EEECCCCCHHHHHHH	24.24	25159151
330	Phosphorylation	ASSVTPESLRKAIEA CCCCCHHHHHHHHHH	34.38	28450419
333	Ubiquitination	VTPESLRKAIEAVSP CCHHHHHHHHHHHCC	60.04	22053931
333 (in isoform 1)	Ubiquitination	-	60.04	22053931
339	Phosphorylation	RKAIEAVSPGLYRVS HHHHHHHCCCEEEEE	21.94	25159151
343	Phosphorylation	EAVSPGLYRVSITSE HHHCCCEEEEEEEEE	18.19	20068231
346	Phosphorylation	SPGLYRVSITSEVES CCCEEEEEEEEEEEE	15.91	23403867
348	Phosphorylation	GLYRVSITSEVESTS CEEEEEEEEEEEECC	16.01	23663014
349	Phosphorylation	LYRVSITSEVESTSN EEEEEEEEEEEECCC	37.67	30177828
353	Phosphorylation	SITSEVESTSNSPSS EEEEEEEECCCCCCC	42.16	30266825
354	Phosphorylation	ITSEVESTSNSPSSS EEEEEEECCCCCCCC	20.58	30266825
355	Phosphorylation	TSEVESTSNSPSSSS EEEEEECCCCCCCCC	44.59	30266825
357	Phosphorylation	EVESTSNSPSSSSLQ EEEECCCCCCCCCCC	26.40	30266825
359	Phosphorylation	ESTSNSPSSSSLQKI EECCCCCCCCCCCCC	42.55	30266825
360	Phosphorylation	STSNSPSSSSLQKIP ECCCCCCCCCCCCCC	27.59	30266825
361	Phosphorylation	TSNSPSSSSLQKIPL CCCCCCCCCCCCCCC	39.13	30266825
362	Phosphorylation	SNSPSSSSLQKIPLN CCCCCCCCCCCCCCC	36.45	29255136
372	Phosphorylation	KIPLNVVSQPLTQET CCCCCEECCCCCCCE	23.07	26074081
376	Phosphorylation	NVVSQPLTQETVINI CEECCCCCCCEEEEE	30.92	26074081
426	Phosphorylation	VEYDPLLTSPETLRG EEECCCCCCHHHHHH	50.33	25002506
427	Phosphorylation	EYDPLLTSPETLRGA EECCCCCCHHHHHHH	22.25	25159151
430	Phosphorylation	PLLTSPETLRGAIED CCCCCHHHHHHHHHH	25.74	24719451
445	Phosphorylation	MGFDATLSDTNEPLV HCCCEECCCCCCCEE	37.73	30576142
447	Phosphorylation	FDATLSDTNEPLVVI CCEECCCCCCCEEEE	37.80	30576142
465	Phosphorylation	SSEMPLLTSTNEFYT CCCCCCCEECCCEEC	40.98	30576142
467	Phosphorylation	EMPLLTSTNEFYTKG CCCCCEECCCEECCC	33.27	30576142
471	Phosphorylation	LTSTNEFYTKGMTPV CEECCCEECCCCCCC	11.02	25884760
476	Phosphorylation	EFYTKGMTPVQDKEE CEECCCCCCCCCHHC	29.04	29255136
517	Phosphorylation	LRREEGIYSILVALM HHHHCCHHHHHHHHH	10.66	18180459
518	Phosphorylation	RREEGIYSILVALMA HHHCCHHHHHHHHHC	13.92	-
594	Phosphorylation	TKHRGILYCSVALAT HHCCCCHHEEEEECC	4.83	-
601	Phosphorylation	YCSVALATNKAHIKY HEEEEECCCCCCCCC	37.79	-
630	Phosphorylation	ESLGFEASLVKKDRS HHCCCEEEEEECCCC	26.88	24719451
633	Ubiquitination	GFEASLVKKDRSASH CCEEEEEECCCCCCC	55.00	-
639	Phosphorylation	VKKDRSASHLDHKRE EECCCCCCCCCHHHH	26.32	28348404
686	N-linked_Glycosylation	ATLHHNQNMSKEEMI HHHCCCCCCCHHHHH	41.85	UniProtKB CARBOHYD
743	Phosphorylation	YKALKHKTANMDVLI HHHHCCCCCCCHHHH	24.00	25262027
754	Phosphorylation	DVLIVLATTIAFAYS HHHHHHHHHHHHHHH	17.99	25262027
755	Phosphorylation	VLIVLATTIAFAYSL HHHHHHHHHHHHHHH	12.52	25262027
760	Phosphorylation	ATTIAFAYSLIILLV HHHHHHHHHHHHHHH	9.50	25262027
761	Phosphorylation	TTIAFAYSLIILLVA HHHHHHHHHHHHHHH	15.06	25262027
770	Phosphorylation	IILLVAMYERAKVNP HHHHHHHHHHHCCCC	7.79	25262027
827	Phosphorylation	ATIVTLDSDNILLSE EEEEEECCCCEEECH	35.35	-
849	Ubiquitination	VQRGDIIKVVPGGKF EECCCEEEECCCCCC	37.20	-
855	Ubiquitination	IKVVPGGKFPVDGRV EEECCCCCCCCCCEE	53.03	-
936 (in isoform 3)	Ubiquitination	-	40.91	-
975	N-linked_Glycosylation	ETYFPGYNRSISRTE HHHCCCCCCCCCCHH	36.82	UniProtKB CARBOHYD
1037	Ubiquitination	EPLEMAHKVKVVVFD CCCCCCEEEEEEEEC	33.92	-
1039	Ubiquitination	LEMAHKVKVVVFDKT CCCCEEEEEEEECCC	33.83	-
1045	Ubiquitination	VKVVVFDKTGTITHG EEEEEECCCCCCCCC	37.07	-
1046	Phosphorylation	KVVVFDKTGTITHGT EEEEECCCCCCCCCC	41.21	23312004
1048	Phosphorylation	VVFDKTGTITHGTPV EEECCCCCCCCCCCE	28.12	23312004
1050	Phosphorylation	FDKTGTITHGTPVVN ECCCCCCCCCCCEEC	17.68	23312004
1053	Phosphorylation	TGTITHGTPVVNQVK CCCCCCCCCEECEEE	12.81	23312004
1060	Ubiquitination	TPVVNQVKVLTESNR CCEECEEEEEECCCC	23.05	-
1132	Ubiquitination	NIEGLLHKNNWNIED CHHHHCCCCCCCCCC	52.53	-
1146	Phosphorylation	DNNIKNASLVQIDAS CCCCCCCEEEEEECC	38.17	26074081
1157	Phosphorylation	IDASNEQSSTSSSMI EECCCCCCCCCCCEE	29.42	22210691
1158	Phosphorylation	DASNEQSSTSSSMII ECCCCCCCCCCCEEH	31.81	22210691
1178	Phosphorylation	NALNAQQYKVLIGNR HCCCHHHEEEEECCC	7.32	22210691
1204	Phosphorylation	NDVNDFMTEHERKGR CCHHHHHHHHHHCCC	33.90	-
1212	Phosphorylation	EHERKGRTAVLVAVD HHHHCCCEEEEEEEC	29.77	-
1245	Phosphorylation	LAIHILKSMGLEVVL HHHHHHHHCCCEEEE	18.03	28270605
1254	Phosphorylation	GLEVVLMTGDNSKTA CCEEEEECCCCHHHH	36.90	28270605
1258	Phosphorylation	VLMTGDNSKTARSIA EEECCCCHHHHHHHH	35.80	28270605
1306	Phosphorylation	VGDGINDSPALAMAN ECCCCCCCHHHHHCC	13.95	-
1410	Phosphorylation	SSLFLKLYRKPTYES HHHHHHHHCCCCCCC	18.27	26074081
1412	Ubiquitination	LFLKLYRKPTYESYE HHHHHHCCCCCCCCC	28.31	-
1414	Phosphorylation	LKLYRKPTYESYELP HHHHCCCCCCCCCCC	42.85	26074081
1415	Phosphorylation	KLYRKPTYESYELPA HHHCCCCCCCCCCCC	16.05	26074081
1417	Phosphorylation	YRKPTYESYELPARS HCCCCCCCCCCCCHH	17.31	26074081
1418	Phosphorylation	RKPTYESYELPARSQ CCCCCCCCCCCCHHH	15.00	26074081
1424	Phosphorylation	SYELPARSQIGQKSP CCCCCCHHHCCCCCC	28.40	-
1430	Phosphorylation	RSQIGQKSPSEISVH HHHCCCCCCCCEEEE	26.27	25159151
1432	Phosphorylation	QIGQKSPSEISVHVG HCCCCCCCCEEEEEE	55.44	21955146
1435	Phosphorylation	QKSPSEISVHVGIDD CCCCCCEEEEEECCC	11.34	25219547
1443	Phosphorylation	VHVGIDDTSRNSPKL EEEECCCCCCCCCCC	26.32	25159151
1444	Phosphorylation	HVGIDDTSRNSPKLG EEECCCCCCCCCCCC	36.14	25159151
1447	Phosphorylation	IDDTSRNSPKLGLLD CCCCCCCCCCCCHHH	23.46	25159151
1449	Ubiquitination	DTSRNSPKLGLLDRI CCCCCCCCCCHHHHH	55.82	-
1459	Phosphorylation	LLDRIVNYSRASINS HHHHHHHCCHHHHHH	6.66	25884760
1460	Phosphorylation	LDRIVNYSRASINSL HHHHHHCCHHHHHHH	19.03	30108239
1463	Phosphorylation	IVNYSRASINSLLSD HHHCCHHHHHHHHCC	22.61	23401153
1466	Phosphorylation	YSRASINSLLSDKRS CCHHHHHHHHCCCCC	29.08	23401153
1469	Phosphorylation	ASINSLLSDKRSLNS HHHHHHHCCCCCCCC	46.51	30266825
1471	Ubiquitination	INSLLSDKRSLNSVV HHHHHCCCCCCCCCC	40.28	-
1473	Phosphorylation	SLLSDKRSLNSVVTS HHHCCCCCCCCCCCC	37.33	29255136
1476	Phosphorylation	SDKRSLNSVVTSEPD CCCCCCCCCCCCCCC	24.21	29255136
1479	Phosphorylation	RSLNSVVTSEPDKHS CCCCCCCCCCCCCCC	25.80	30108239
1480	Phosphorylation	SLNSVVTSEPDKHSL CCCCCCCCCCCCCCE	35.21	21815630
1486	Phosphorylation	TSEPDKHSLLVGDFR CCCCCCCCEEEECCC	29.19	30108239
1498	Phosphorylation	DFREDDDTAL----- CCCCCCCCCC-----	36.53	24719451
1552 (in isoform 3)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1424	S	Phosphorylation	Kinase	AKT2	P31751	PSP
1463	S	Phosphorylation	Kinase	AKT2	P31751	PSP
1466	S	Phosphorylation	Kinase	AKT2	P31751	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATP7A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATP7A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLRX1_HUMAN	GLRX	physical	16884690
ATOX1_HUMAN	ATOX1	physical	10497213
CLUS_HUMAN	CLU	physical	21242307
COMD1_HUMAN	COMMD1	physical	22130675

Drug and Disease Associations

• Kegg Disease
• H00209: Menkes disease (MD); Menkes kinky hair syndrome
• H00455: Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II
• H00557: Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1
• H00856: Distal hereditary motor neuropathies (dHMN)
• OMIM Disease
• 309400: Menkes disease (MNKD)
• 304150: Occipital horn syndrome (OHS)
• 300489: Distal spinal muscular atrophy, X-linked, 3 (DSMAX3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00958: Carboplatin
• DB00515: Cisplatin
• DB00526: Oxaliplatin