CU002_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CU002_HUMAN
• UniProt AC: O43822
• Protein Name: Protein C21orf2
• Gene Name: C21orf2
• Organism: Homo sapiens (Human).
• Sequence Length: 256
• Subcellular Localization: Mitochondrion . Cytoplasm, cytoskeleton, cilium basal body . Cell projection, cilium, photoreceptor outer segment . Cytoplasm . Colocalizes with NEK1 and SPATA7 at the basal body.
• Protein Description: Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. [PubMed: 21834987 Involved in DNA damage repair]
• Protein Sequence: MKLTRKMVLTRAKASELHSVRKLNCWGSRLTDISICQEMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELFYLKGLPRLRVLWLAENPCCGTSPHRYRMTVLRTLPRLQKLDNQAVTEEELSRALSEGEEITAAPEREGTGHGGPKLCCTLSSLSSAAETGRDPLDSEEEATSGAQDERGLKPPSRGQFPSLSARDASSSHRGRNVLTAILLLLRELDAEGLEAVQQTVGSRLQALRGEEVQEHAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79 (in isoform 2)	Ubiquitination	-	44.71	21906983
120	Acetylation	RTLPRLQKLDNQAVT HHHHHHHHHCCCCCC	63.50	25953088
120 (in isoform 1)	Ubiquitination	-	63.50	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CU002_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CU002_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CU002_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMCL1_HUMAN	GMCL1	physical	25416956
NEK1_HUMAN	NEK1	physical	27173435
VTNC_HUMAN	VTN	physical	27173435
FTM_HUMAN	RPGRIP1L	physical	27173435
SPAT7_HUMAN	SPATA7	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
2AAA_HUMAN	PPP2R1A	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-102; SER-136; SER-177;SER-201 AND THR-238, AND MASS SPECTROMETRY.
PubMed: 19369195