SPAT7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPAT7_HUMAN
• UniProt AC: Q9P0W8
• Protein Name: Spermatogenesis-associated protein 7
• Gene Name: SPATA7
• Organism: Homo sapiens (Human).
• Sequence Length: 599
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton . Localizes to the microtubule network (PubMed:25398945). In the retinal photoreceptor cell layer, localizes at the connecting cilium (By s
• Protein Description: Involved in photoreceptor cells maintenance (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as protein trafficking across the CC to the outer segments (By similarity)..
• Protein Sequence: MDGSRRVRATSVLPRYGPPCLFKGHLSTKSNAFCTDSSSLRLSTLQLVKNHMAVHYNKILSAKAAVDCSVPVSVSTSIKYADQQRREKLKKELAQCEKEFKLTKTAMRANYKNNSKSLFNTLQKPSGEPQIEDDMLKEEMNGFSSFARSLVPSSERLHLSLHKSSKVITNGPEKNSSSSPSSVDYAASGPRKLSSGALYGRRPRSTFPNSHRFQLVISKAPSGDLLDKHSELFSNKQLPFTPRTLKTEAKSFLSQYRYYTPAKRKKDFTDQRIEAETQTELSFKSELGTAETKNMTDSEMNIKQASNCVTYDAKEKIAPLPLEGHDSTWDEIKDDALQHSSPRAMCQYSLKPPSTRKIYSDEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHLEEEKMRHLLHVLKVDLGCTSEENSVKQNDVDMLNVFDFEKAGNSEPNELKNESEVTIQQERQQYQKALDMLLSAPKDENEIFPSPTEFFMPIYKSKHSEGVIIQQVNDETNLETSTLDENHPSISDSLTDRETSVNVIEGDSDPEKVEISNGLCGLNTSPSQSVQFSSVKGDNNHDMELSTLKIMEMSIEDCPLDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Methylation	MDGSRRVRATSVLPR CCCCCCEECCCCCCC	30.27	115917569
10	Phosphorylation	GSRRVRATSVLPRYG CCCCEECCCCCCCCC	14.59	25278378
11	Phosphorylation	SRRVRATSVLPRYGP CCCEECCCCCCCCCC	22.22	25278378
15	Methylation	RATSVLPRYGPPCLF ECCCCCCCCCCCCEE	44.90	115917565
16	Phosphorylation	ATSVLPRYGPPCLFK CCCCCCCCCCCCEEE	31.85	29759185
28	Phosphorylation	LFKGHLSTKSNAFCT EEECCCCCCCCCEEC	44.87	29759185
39	Phosphorylation	AFCTDSSSLRLSTLQ CEECCCCCCCHHHHH	22.81	-
104	Ubiquitination	EKEFKLTKTAMRANY HHHHHHHHHHHHHHH	44.73	-
144	Phosphorylation	KEEMNGFSSFARSLV HHHHCCCHHHHHHHC	26.41	-
145	Phosphorylation	EEMNGFSSFARSLVP HHHCCCHHHHHHHCC	22.21	-
174	Ubiquitination	VITNGPEKNSSSSPS EECCCCCCCCCCCCC	66.32	-
179	Phosphorylation	PEKNSSSSPSSVDYA CCCCCCCCCCCCCCC	30.65	25627689
182	Phosphorylation	NSSSSPSSVDYAASG CCCCCCCCCCCCCCC	23.53	22468782
185	Phosphorylation	SSPSSVDYAASGPRK CCCCCCCCCCCCCCC	11.25	22468782
188	Phosphorylation	SSVDYAASGPRKLSS CCCCCCCCCCCCCCC	40.95	22468782
194	Phosphorylation	ASGPRKLSSGALYGR CCCCCCCCCCCCCCC	29.75	27966365
195	Phosphorylation	SGPRKLSSGALYGRR CCCCCCCCCCCCCCC	38.22	28857561
206	Phosphorylation	YGRRPRSTFPNSHRF CCCCCCCCCCCCCCE	44.37	-
219	Ubiquitination	RFQLVISKAPSGDLL CEEEEEECCCCCCCC	53.87	-
222	Phosphorylation	LVISKAPSGDLLDKH EEEECCCCCCCCHHH	50.20	28348404
228	Ubiquitination	PSGDLLDKHSELFSN CCCCCCHHHHHHHCC	49.34	-
230	Phosphorylation	GDLLDKHSELFSNKQ CCCCHHHHHHHCCCC	41.56	30622161
234	Phosphorylation	DKHSELFSNKQLPFT HHHHHHHCCCCCCCC	56.60	30622161
236	Ubiquitination	HSELFSNKQLPFTPR HHHHHCCCCCCCCCC	52.60	-
254	Phosphorylation	TEAKSFLSQYRYYTP HHHHHHHHHHCCCCC	24.13	24719451
258	Phosphorylation	SFLSQYRYYTPAKRK HHHHHHCCCCCCCCC	13.52	24719451
259	Phosphorylation	FLSQYRYYTPAKRKK HHHHHCCCCCCCCCC	9.39	24719451
282	Phosphorylation	AETQTELSFKSELGT HHHHCCEEEEHHHCC	25.13	24719451
285	Phosphorylation	QTELSFKSELGTAET HCCEEEEHHHCCCHH	35.72	26356563
289	Phosphorylation	SFKSELGTAETKNMT EEEHHHCCCHHCCCC	33.66	26356563
292	Phosphorylation	SELGTAETKNMTDSE HHHCCCHHCCCCHHC	25.84	26356563
296	Phosphorylation	TAETKNMTDSEMNIK CCHHCCCCHHCCHHH	45.85	30622161
298	Phosphorylation	ETKNMTDSEMNIKQA HHCCCCHHCCHHHHH	29.58	30622161
316	Ubiquitination	VTYDAKEKIAPLPLE EECCCCCCCCCCCCC	43.38	-
333	Ubiquitination	DSTWDEIKDDALQHS CCCHHHHHHHHHHHC	47.73	-
340	Phosphorylation	KDDALQHSSPRAMCQ HHHHHHHCCCCCHHH	29.13	23898821
341	Phosphorylation	DDALQHSSPRAMCQY HHHHHHCCCCCHHHH	19.11	27251275
349	Phosphorylation	PRAMCQYSLKPPSTR CCCHHHHCCCCCCCC	12.21	24719451
456	Phosphorylation	PNELKNESEVTIQQE CCCCCCHHHCCHHHH	46.92	30622161
459	Phosphorylation	LKNESEVTIQQERQQ CCCHHHCCHHHHHHH	14.71	30622161
467	Phosphorylation	IQQERQQYQKALDML HHHHHHHHHHHHHHH	12.02	-
469	Ubiquitination	QERQQYQKALDMLLS HHHHHHHHHHHHHHH	46.08	-
536	Phosphorylation	DSLTDRETSVNVIEG HHCCCCCCCEEEECC	38.58	29083192
537	Phosphorylation	SLTDRETSVNVIEGD HCCCCCCCEEEECCC	13.62	29083192
545	Phosphorylation	VNVIEGDSDPEKVEI EEEECCCCCHHHEEE	66.96	29083192
561	Phosphorylation	NGLCGLNTSPSQSVQ CCCCCCCCCCCCEEE	47.24	30622161
562	Phosphorylation	GLCGLNTSPSQSVQF CCCCCCCCCCCEEEE	22.83	30622161
564	Phosphorylation	CGLNTSPSQSVQFSS CCCCCCCCCEEEEEE	34.55	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPAT7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPAT7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPAT7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.