dbPTM

GSTT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GSTT1_HUMAN
UniProt AC	P30711
Protein Name	Glutathione S-transferase theta-1
Gene Name	GSTT1
Organism	Homo sapiens (Human).
Sequence Length	240
Subcellular Localization	Cytoplasm.
Protein Description	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide..
Protein Sequence	MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDGDFTLTESVAILLYLTRKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMFPVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGAGCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAKDFPPADPTIKQKLMPWVLAMIR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	AVYIFAKKNDIPFEL EEEEEECCCCCCEEE	57.32	-
52	Ubiquitination	FAQVNPLKKVPALKD HHHCCCCCCCCCCCC	53.64	-
63	Phosphorylation	ALKDGDFTLTESVAI CCCCCCCCCCHHHHH	37.19	29978859
65	Phosphorylation	KDGDFTLTESVAILL CCCCCCCCHHHHHHH	24.13	29978859
67	Phosphorylation	GDFTLTESVAILLYL CCCCCCHHHHHHHHH	16.18	29978859
73	Phosphorylation	ESVAILLYLTRKYKV HHHHHHHHHHHHCCC	11.55	29978859
75	Phosphorylation	VAILLYLTRKYKVPD HHHHHHHHHHCCCCC	16.14	29978859
83	Phosphorylation	RKYKVPDYWYPQDLQ HHCCCCCCCCCHHHH	10.77	27259358
85	Phosphorylation	YKVPDYWYPQDLQAR CCCCCCCCCHHHHHH	5.70	27259358
216	Ubiquitination	EAHEVILKAKDFPPA HHHHHHHHCCCCCCC	42.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GSTT1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GSTT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GSTT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI18_HUMAN	MID1	physical	28514442
MYLK2_HUMAN	MYLK2	physical	28514442
HBB_HUMAN	HBB	physical	28514442
SIR2_HUMAN	SIRT2	physical	28514442
TRY2_HUMAN	PRSS2	physical	28514442
SPRTN_HUMAN	SPRTN	physical	28514442
LURA1_HUMAN	LURAP1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00958	Carboplatin
DB00515	Cisplatin
DB00773	Etoposide
DB00143	Glutathione
DB00526	Oxaliplatin

Regulatory Network of GSTT1_HUMAN

Related Literatures of Post-Translational Modification