MYLK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYLK2_HUMAN
• UniProt AC: Q9H1R3
• Protein Name: Myosin light chain kinase 2, skeletal/cardiac muscle
• Gene Name: MYLK2
• Organism: Homo sapiens (Human).
• Sequence Length: 596
• Subcellular Localization: Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
• Protein Description: Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain..
• Protein Sequence: MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASEKGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGSQDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVPMTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEVGQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATENGAVE ------CCCCCCCEE	24.50	-
49	Phosphorylation	KKAPDPPTLKKDAKA CCCCCCCCCCCCCCC	57.51	26437602
103	Phosphorylation	ALPQQTATPETSVKK CCCCCCCCCCCCCCC	25.66	26437602
120	Phosphorylation	AEQGASGSQDPGKPR HHCCCCCCCCCCCCC	28.99	26437602
143	Phosphorylation	QAAARRGSPAFLHSP HHHHHCCCCCCCCCC	15.96	19764811
149	Phosphorylation	GSPAFLHSPSCPAII CCCCCCCCCCCCEEC	22.21	26437602
151	Phosphorylation	PAFLHSPSCPAIISS CCCCCCCCCCEECCC	35.43	26437602
157	Phosphorylation	PSCPAIISSSEKLLA CCCCEECCCCHHHHC	23.00	22673903
158	Phosphorylation	SCPAIISSSEKLLAK CCCEECCCCHHHHCC	31.91	22673903
159	Phosphorylation	CPAIISSSEKLLAKK CCEECCCCHHHHCCC	31.77	22673903
184	Phosphorylation	EGVPMTHSPTDPRPA ECCCCCCCCCCCCCC	21.96	26437602
276	Phosphorylation	HRMVELRTGNVSSEF CCEEEECCCCCCCCE	45.81	29978859
280	Phosphorylation	ELRTGNVSSEFSMNS EECCCCCCCCEECCC	28.31	29978859
281	Phosphorylation	LRTGNVSSEFSMNSK ECCCCCCCCEECCCC	38.08	29978859
284	Phosphorylation	GNVSSEFSMNSKEAL CCCCCCEECCCCCHH	17.01	29978859
287	Phosphorylation	SSEFSMNSKEALGGG CCCEECCCCCHHCCC	24.19	29978859
445	Phosphorylation	KLKVNFGTPEFLSPE CCEEECCCCCCCCHH	18.59	-
561	Ubiquitination	LKSQILLKKYLMKRR HHHHHHHHHHHHHCC	35.61	29967540
563	Phosphorylation	SQILLKKYLMKRRWK HHHHHHHHHHHCCCH	15.50	19835603
584	Ubiquitination	SAANRFKKISSSGAL HHHHHHHHHCCCCCC	45.14	-
586	Phosphorylation	ANRFKKISSSGALMA HHHHHHHCCCCCCHH	27.60	19764811
587	Phosphorylation	NRFKKISSSGALMAL HHHHHHCCCCCCHHC	35.94	19764811
588	Phosphorylation	RFKKISSSGALMALG HHHHHCCCCCCHHCC	22.69	19764811

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYLK2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYLK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYLK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FBX11_HUMAN	FBXO11	physical	26186194
KS6A4_HUMAN	RPS6KA4	physical	26186194
KS6A4_HUMAN	RPS6KA4	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 192600: Cardiomyopathy, familial hypertrophic (CMH)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.