GGPPS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GGPPS_HUMAN
• UniProt AC: O95749
• Protein Name: Geranylgeranyl pyrophosphate synthase
• Gene Name: GGPS1
• Organism: Homo sapiens (Human).
• Sequence Length: 300
• Subcellular Localization: Cytoplasm.
• Protein Description: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins..
• Protein Sequence: MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEKTQETV -------CCHHHHHH	12.29	22814378
3	Ubiquitination	-----MEKTQETVQR -----CCHHHHHHHH	54.96	-
16	Phosphorylation	QRILLEPYKYLLQLP HHHHHHHHHHHHCCC	11.68	25884760
17	Ubiquitination	RILLEPYKYLLQLPG HHHHHHHHHHHCCCC	39.89	21890473
17	Ubiquitination	RILLEPYKYLLQLPG HHHHHHHHHHHCCCC	39.89	-
25	Acetylation	YLLQLPGKQVRTKLS HHHCCCCHHHHHHHH	43.62	19608861
25	Malonylation	YLLQLPGKQVRTKLS HHHCCCCHHHHHHHH	43.62	26320211
30	Acetylation	PGKQVRTKLSQAFNH CCHHHHHHHHHHHHH	35.26	25953088
59	Ubiquitination	VTEMLHNASLLIDDI HHHHHHHCHHEECCC	7.27	21890473
60	Phosphorylation	TEMLHNASLLIDDIE HHHHHHCHHEECCCC	29.09	20363803
70	Phosphorylation	IDDIEDNSKLRRGFP ECCCCCCCHHCCCCC	45.44	20363803
71	Ubiquitination	DDIEDNSKLRRGFPV CCCCCCCHHCCCCCC	52.87	-
87	Phosphorylation	HSIYGIPSVINSANY HHHHCCCHHHCCCCE	33.44	19835603
91	Phosphorylation	GIPSVINSANYVYFL CCCHHHCCCCEEEEE	13.53	19835603
94	Phosphorylation	SVINSANYVYFLGLE HHHCCCCEEEEECCE	9.02	19835603
113	Ubiquitination	LDHPDAVKLFTRQLL CCCHHHHHHHHHHHH	39.33	21890473
142	Ubiquitination	NYTCPTEEEYKAMVL CCCCCCHHHHHHHHH	69.93	-
196	Ubiquitination	DYANLHSKEYSENKS HHHHCCCCCCCCCCC	50.34	21890473
202	Ubiquitination	SKEYSENKSFCEDLT CCCCCCCCCCCCHHH	40.64	-
203	Phosphorylation	KEYSENKSFCEDLTE CCCCCCCCCCCHHHC	46.87	21815630
219	Ubiquitination	KFSFPTIHAIWSRPE CCCCCCHHHHHCCCC	17.40	-
263	Phosphorylation	SFEYTRNTLKELEAK CCCCCHHHHHHHHHH	35.60	29759185
265	Ubiquitination	EYTRNTLKELEAKAY CCCHHHHHHHHHHHH	59.21	-
265	Acetylation	EYTRNTLKELEAKAY CCCHHHHHHHHHHHH	59.21	25953088
270	Acetylation	TLKELEAKAYKQIDA HHHHHHHHHHHHHHC	42.76	25953088
272	Phosphorylation	KELEAKAYKQIDARG HHHHHHHHHHHHCCC	11.61	22817900
273	Ubiquitination	ELEAKAYKQIDARGG HHHHHHHHHHHCCCC	45.71	-
273	Acetylation	ELEAKAYKQIDARGG HHHHHHHHHHHCCCC	45.71	25953088
278	Methylation	AYKQIDARGGNPELV HHHHHHCCCCCHHHH	50.21	-
289	Acetylation	PELVALVKHLSKMFK HHHHHHHHHHHHHHH	39.41	25953088
293	Acetylation	ALVKHLSKMFKEENE HHHHHHHHHHHHHCC	55.50	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GGPPS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GGPPS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GGPPS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GGPPS_HUMAN	GGPS1	physical	25416956
F120A_HUMAN	FAM120A	physical	26186194
ZN696_HUMAN	ZNF696	physical	26186194
IQGA1_HUMAN	IQGAP1	physical	26186194
CC85C_HUMAN	CCDC85C	physical	26186194
HXA5_HUMAN	HOXA5	physical	26186194
SLTM_HUMAN	SLTM	physical	26186194
TUSC1_HUMAN	TUSC1	physical	26186194
RS14_HUMAN	RPS14	physical	26344197
RUXE_HUMAN	SNRPE	physical	26344197
TUSC1_HUMAN	TUSC1	physical	28514442
IQGA1_HUMAN	IQGAP1	physical	28514442
SLTM_HUMAN	SLTM	physical	28514442
F120A_HUMAN	FAM120A	physical	28514442
CC85C_HUMAN	CCDC85C	physical	28514442
ZN696_HUMAN	ZNF696	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00399: Zoledronate

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-25, AND MASS SPECTROMETRY.
PubMed: 19608861